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• W2116823037 endingPage "1032" @default.
• W2116823037 startingPage "1020" @default.
• W2116823037 abstract "Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) by the liver. Hepatic lipase (HL) promotes this lipid uptake independent from lipolysis. The role of SR-BI in this HL-mediated increase in selective CE uptake was explored. Baby hamster kidney (BHK) cells were transfected with the SR-BI cDNA yielding cells with SR-BI expression, whereas no SR-BI was detected in control cells. These cells were incubated in medium containing ¹²⁵I [³H]cholesteryl oleyl ether-labeled HDL₃ (d = 1.125–1.21 g/ml) and HL was absent or present. Tetrahydrolipstatin (THL) blocked lipolysis. In control BHK cells and in BHK cells with SR-BI, HDL₃ selective CE uptake (³H-¹²⁵I) was detectable and SR-BI promoted this uptake. In both cell types, HL mediated an increase in selective CE uptake from HDL₃. Quantitatively, this HL effect was similar in control BHK cells and in BHK cells with SR-BI. These results suggest that HL promotes selective uptake independent from SR-BI. To investigate the role of cell surface proteoglycans on the HL-mediated HDL₃ uptake, proteoglycan deficiency was induced by heparinase digestion. Proteoglycan deficiency decreased the HL-mediated promotion of selective CE uptake. In summary, the stimulating HL effect on HDL selective CE uptake is independent from SR-BI and lipolysis. Proteoglycans are a requisite for the HL action on selective uptake. Results suggest that (a) pathway(s) distinct from SR-BI mediate(s) selective CE uptake from HDL." @default.
• W2116823037 created "2016-06-24" @default.
• W2116823037 creator A5005653232 @default.
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• W2116823037 date "2003-05-01" @default.
• W2116823037 modified "2023-10-18" @default.
• W2116823037 title "Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI" @default.
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• W2116823037 doi "https://doi.org/10.1194/jlr.m300058-jlr200" @default.
• W2116823037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12611911" @default.
• W2116823037 hasPublicationYear "2003" @default.
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