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• W2116826427 startingPage "6675" @default.
• W2116826427 abstract "Genomes contain tandem repeat blocks that are at risk of expansion or contraction. The mechanisms of destabilization of the human minisatellite CEB1 (arrays of 36- to 43-bp repeats) were investigated in a previously developed model system, in which CEB1-0.6 (14 repeats) and CEB1-1.8 (42 repeats) alleles were inserted into the genome of Saccharomyces cerevisiae. As in human cells, CEB1 is stable in mitotically growing yeast cells but is frequently rearranged in the absence of the Rad27/hFEN1 protein involved in Okazaki fragments maturation. To gain insight into this mode of destabilization, the CEB1-1.8 and CEB1-0.6 human alleles and 47 rearrangements derived from a CEB1-1.8 progenitor in rad27Delta cells were sequenced. A high degree of polymorphism of CEB1 internal repeats was observed, attesting to a large variety of homology-driven rearrangements. Simple deletion, double deletion, and highly complex events were observed. Pedigree analysis showed that all rearrangements, even the most complex, occurred in a single generation and were inherited equally by mother and daughter cells. Finally, the rearrangement frequency was found to increase with array size, and partial complementation of the rad27Delta mutation by hFEN1 demonstrated that the production of novel CEB1 alleles is Rad52 and Rad51 dependent. Instability can be explained by an accumulation of unresolved flap structures during replication, leading to the formation of recombinogenic lesions and faulty repair, best understood by homology-dependent synthesis-strand displacement and annealing." @default.
• W2116826427 created "2016-06-24" @default.
• W2116826427 creator A5016801869 @default.
• W2116826427 creator A5066676166 @default.
• W2116826427 creator A5088349709 @default.
• W2116826427 date "2006-09-01" @default.
• W2116826427 modified "2023-10-18" @default.
• W2116826427 title "Complex Minisatellite Rearrangements Generated in the Total or Partial Absence of Rad27<i>/</i>hFEN1 Activity Occur in a Single Generation and Are Rad51 and Rad52 Dependent" @default.
• W2116826427 cites W1506492200 @default.
• W2116826427 cites W1519003053 @default.
• W2116826427 cites W1605809999 @default.
• W2116826427 cites W1729887059 @default.
• W2116826427 cites W175491683 @default.
• W2116826427 cites W1842945194 @default.
• W2116826427 cites W1888032283 @default.
• W2116826427 cites W1958566893 @default.
• W2116826427 cites W1969896771 @default.
• W2116826427 cites W1972746487 @default.
• W2116826427 cites W1973611733 @default.
• W2116826427 cites W1982092236 @default.
• W2116826427 cites W1984945120 @default.
• W2116826427 cites W1987882116 @default.
• W2116826427 cites W1989398199 @default.
• W2116826427 cites W2001682487 @default.
• W2116826427 cites W2003329456 @default.
• W2116826427 cites W2004691787 @default.
• W2116826427 cites W2006268714 @default.
• W2116826427 cites W2010251411 @default.
• W2116826427 cites W2010302368 @default.
• W2116826427 cites W2012306350 @default.
• W2116826427 cites W2020390201 @default.
• W2116826427 cites W2023745096 @default.
• W2116826427 cites W2026745781 @default.
• W2116826427 cites W2028138760 @default.
• W2116826427 cites W2029342880 @default.
• W2116826427 cites W2029572737 @default.
• W2116826427 cites W2033249365 @default.
• W2116826427 cites W2033676950 @default.
• W2116826427 cites W2034957838 @default.
• W2116826427 cites W2035994249 @default.
• W2116826427 cites W2038336865 @default.
• W2116826427 cites W2038529419 @default.
• W2116826427 cites W2048673274 @default.
• W2116826427 cites W2051052655 @default.
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• W2116826427 cites W2055491585 @default.
• W2116826427 cites W2059106521 @default.
• W2116826427 cites W2069157381 @default.
• W2116826427 cites W2079634216 @default.
• W2116826427 cites W2083422396 @default.
• W2116826427 cites W2087850275 @default.
• W2116826427 cites W2088489316 @default.
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• W2116826427 cites W2136218692 @default.
• W2116826427 cites W2138539875 @default.
• W2116826427 cites W2138971880 @default.
• W2116826427 cites W2144550200 @default.
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• W2116826427 doi "https://doi.org/10.1128/mcb.00649-06" @default.
• W2116826427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1592832" @default.
• W2116826427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16914748" @default.
• W2116826427 hasPublicationYear "2006" @default.
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