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- W2116850469 endingPage "2084" @default.
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- W2116850469 abstract "The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (D mu). Positive selection is known to be mediated by membrane immunoglobulin heavy chains through Ig alpha-Ig beta, whereas the mechanism for counterselection against D mu has not been determined. We have examined the role of the Ig alpha-Ig beta signal transducers in counterselection against D mu using mice that lack Ig beta. We found that D mu expression is not selected against in developing B cells in Ig beta mutant mice. Thus, the molecular mechanism for counterselection against D mu in pre-B cells resembles positive selection in that it requires interaction between mD mu and Ig alpha-Ig beta." @default.
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- W2116850469 date "1996-12-01" @default.
- W2116850469 modified "2023-09-23" @default.
- W2116850469 title "Counterselection against Dμ Is Mediated through Immunoglobulin (Ig)α-Igβ" @default.
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- W2116850469 doi "https://doi.org/10.1084/jem.184.6.2079" @default.
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