FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116861212> ?p ?o ?g. }

• W2116861212 endingPage "347" @default.
• W2116861212 startingPage "342" @default.
• W2116861212 abstract "RhoA and Rho kinase are important modulators of microvascular tone.We tested whether sphingosine kinase (Sphk1) that generates the endogenous sphingolipid mediator sphingosine-1-phosphate (S1P) is part of a signaling cascade to activate the RhoA/Rho kinase pathway. Using a new transfection model, we report that resting tone and myogenic responses of isolated resistance arteries increased with forced expression of Sphk1 in smooth muscle cells of these arteries. Overexpression of a dominant negative Sphk1 mutant or coexpression of dominant negative mutants of RhoA or Rho kinase together with Sphk1 completely inhibited development of tone and myogenic responses.The tone-increasing effects of a Sphk1 overexpression suggest that Sphk1 may play an important role in the control of peripheral resistance." @default.
• W2116861212 created "2016-06-24" @default.
• W2116861212 creator A5000084814 @default.
• W2116861212 creator A5014072958 @default.
• W2116861212 creator A5015996015 @default.
• W2116861212 creator A5032213369 @default.
• W2116861212 creator A5049420090 @default.
• W2116861212 creator A5063674155 @default.
• W2116861212 creator A5070560020 @default.
• W2116861212 creator A5086247039 @default.
• W2116861212 date "2003-07-22" @default.
• W2116861212 modified "2023-10-17" @default.
• W2116861212 title "Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase" @default.
• W2116861212 cites W1497432777 @default.
• W2116861212 cites W1597787921 @default.
• W2116861212 cites W194397449 @default.
• W2116861212 cites W1981852211 @default.
• W2116861212 cites W1996629436 @default.
• W2116861212 cites W1997242049 @default.
• W2116861212 cites W2024106968 @default.
• W2116861212 cites W2056107385 @default.
• W2116861212 cites W2074994056 @default.
• W2116861212 cites W2075468442 @default.
• W2116861212 cites W2134603143 @default.
• W2116861212 cites W2141921458 @default.
• W2116861212 cites W2143503998 @default.
• W2116861212 cites W2259495851 @default.
• W2116861212 cites W2337785707 @default.
• W2116861212 cites W2404755821 @default.
• W2116861212 doi "https://doi.org/10.1161/01.cir.0000080324.12530.0d" @default.
• W2116861212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12847068" @default.
• W2116861212 hasPublicationYear "2003" @default.
• W2116861212 type Work @default.
• W2116861212 sameAs 2116861212 @default.
• W2116861212 citedByCount "138" @default.
• W2116861212 countsByYear W21168612122012 @default.
• W2116861212 countsByYear W21168612122013 @default.
• W2116861212 countsByYear W21168612122014 @default.
• W2116861212 countsByYear W21168612122015 @default.
• W2116861212 countsByYear W21168612122016 @default.
• W2116861212 countsByYear W21168612122017 @default.
• W2116861212 countsByYear W21168612122018 @default.
• W2116861212 countsByYear W21168612122019 @default.
• W2116861212 countsByYear W21168612122020 @default.
• W2116861212 countsByYear W21168612122021 @default.
• W2116861212 countsByYear W21168612122023 @default.
• W2116861212 crossrefType "journal-article" @default.
• W2116861212 hasAuthorship W2116861212A5000084814 @default.
• W2116861212 hasAuthorship W2116861212A5014072958 @default.
• W2116861212 hasAuthorship W2116861212A5015996015 @default.
• W2116861212 hasAuthorship W2116861212A5032213369 @default.
• W2116861212 hasAuthorship W2116861212A5049420090 @default.
• W2116861212 hasAuthorship W2116861212A5063674155 @default.
• W2116861212 hasAuthorship W2116861212A5070560020 @default.
• W2116861212 hasAuthorship W2116861212A5086247039 @default.
• W2116861212 hasBestOaLocation W21168612121 @default.
• W2116861212 hasConcept C126322002 @default.
• W2116861212 hasConcept C134018914 @default.
• W2116861212 hasConcept C170493617 @default.
• W2116861212 hasConcept C184235292 @default.
• W2116861212 hasConcept C201800478 @default.
• W2116861212 hasConcept C2776596873 @default.
• W2116861212 hasConcept C2777093181 @default.
• W2116861212 hasConcept C2777550365 @default.
• W2116861212 hasConcept C2777700496 @default.
• W2116861212 hasConcept C2778703144 @default.
• W2116861212 hasConcept C61705674 @default.
• W2116861212 hasConcept C62478195 @default.
• W2116861212 hasConcept C71924100 @default.
• W2116861212 hasConcept C86803240 @default.
• W2116861212 hasConcept C95444343 @default.
• W2116861212 hasConcept C97029542 @default.
• W2116861212 hasConceptScore W2116861212C126322002 @default.
• W2116861212 hasConceptScore W2116861212C134018914 @default.
• W2116861212 hasConceptScore W2116861212C170493617 @default.
• W2116861212 hasConceptScore W2116861212C184235292 @default.
• W2116861212 hasConceptScore W2116861212C201800478 @default.
• W2116861212 hasConceptScore W2116861212C2776596873 @default.
• W2116861212 hasConceptScore W2116861212C2777093181 @default.
• W2116861212 hasConceptScore W2116861212C2777550365 @default.
• W2116861212 hasConceptScore W2116861212C2777700496 @default.
• W2116861212 hasConceptScore W2116861212C2778703144 @default.
• W2116861212 hasConceptScore W2116861212C61705674 @default.
• W2116861212 hasConceptScore W2116861212C62478195 @default.
• W2116861212 hasConceptScore W2116861212C71924100 @default.
• W2116861212 hasConceptScore W2116861212C86803240 @default.
• W2116861212 hasConceptScore W2116861212C95444343 @default.
• W2116861212 hasConceptScore W2116861212C97029542 @default.
• W2116861212 hasIssue "3" @default.
• W2116861212 hasLocation W21168612121 @default.
• W2116861212 hasLocation W21168612122 @default.
• W2116861212 hasOpenAccess W2116861212 @default.
• W2116861212 hasPrimaryLocation W21168612121 @default.
• W2116861212 hasRelatedWork W114681587 @default.
• W2116861212 hasRelatedWork W1800709868 @default.
• W2116861212 hasRelatedWork W1991575691 @default.
• W2116861212 hasRelatedWork W2084654786 @default.
• W2116861212 hasRelatedWork W2356739021 @default.

• next