FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116875019> ?p ?o ?g. }

• W2116875019 endingPage "89" @default.
• W2116875019 startingPage "89" @default.
• W2116875019 abstract "Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? U Deniz DincerDepartment of Pharmacology, Ufuk University School of Medicine. Mevlana Bulvari, Balgat, Ankara, TurkeyAbstract: Metabolic syndrome is characterized by a combination of obesity, hypertension, insulin resistance, dyslipidemia, and impaired glucose tolerance. This multifaceted syndrome is often accompanied by a hyperdynamic circulatory state characterized by increased blood pressure, total blood volume, cardiac output, and metabolic tissue demand. Experimental, epidemiological, and clinical studies have demonstrated that patients with metabolic syndrome have significantly elevated cardiovascular morbidity and mortality rates. One of the main and frequent complications seen in metabolic syndrome is cardiovascular disease. The primary endpoints of cardiometabolic risk are coronary and peripheral arterial disease, myocardial infarction, congestive heart failure, arrhythmia, and stroke. Alterations in expression and/or functioning of several key proteins involved in regulating and maintaining ionic homeostasis can cause cardiac disturbances. One such group of proteins is known as ryanodine receptors (intracellular calcium release channels), which are the major channels through which Ca2+ ions leave the sarcoplasmic reticulum, leading to cardiac muscle contraction. The economic cost of metabolic syndrome and its associated complications has a significant effect on health care budgets. Improvements in body weight, blood lipid profile, and hyperglycemia can reduce cardiometabolic risk. However, constant hyperadrenergic stimulation still contributes to the burden of disease. Normalization of the hyperdynamic circulatory state with conventional therapies is the most reasonable therapeutic strategy to date. JTV519 (K201) is a newly developed 1,4-benzothiazepine drug with antiarrhythmic and cardioprotective properties. It appears to be very effective in not only preventing but also in reversing the characteristic myocardial changes and preventing lethal arrhythmias. It is also a unique candidate to improve diastolic heart failure in metabolic syndrome.Keywords: ryanodine receptors, metabolic syndrome, JTV519, K201" @default.
• W2116875019 created "2016-06-24" @default.
• W2116875019 creator A5008538142 @default.
• W2116875019 date "2012-04-01" @default.
• W2116875019 modified "2023-09-29" @default.
• W2116875019 title "Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?" @default.
• W2116875019 cites W1598150429 @default.
• W2116875019 cites W1608391534 @default.
• W2116875019 cites W1819973517 @default.
• W2116875019 cites W1849771780 @default.
• W2116875019 cites W1892323012 @default.
• W2116875019 cites W1921927774 @default.
• W2116875019 cites W1966758360 @default.
• W2116875019 cites W1969508851 @default.
• W2116875019 cites W1970243543 @default.
• W2116875019 cites W1972230645 @default.
• W2116875019 cites W1974579241 @default.
• W2116875019 cites W1976215917 @default.
• W2116875019 cites W1978916317 @default.
• W2116875019 cites W1979544826 @default.
• W2116875019 cites W1982594839 @default.
• W2116875019 cites W1986724453 @default.
• W2116875019 cites W1987187257 @default.
• W2116875019 cites W1987284716 @default.
• W2116875019 cites W1991605305 @default.
• W2116875019 cites W1991883061 @default.
• W2116875019 cites W1995722317 @default.
• W2116875019 cites W2003437932 @default.
• W2116875019 cites W2011371702 @default.
• W2116875019 cites W2015852718 @default.
• W2116875019 cites W2016512210 @default.
• W2116875019 cites W2022691975 @default.
• W2116875019 cites W2023385878 @default.
• W2116875019 cites W2025555937 @default.
• W2116875019 cites W2026789606 @default.
• W2116875019 cites W2027607873 @default.
• W2116875019 cites W2028161610 @default.
• W2116875019 cites W2028982808 @default.
• W2116875019 cites W2031215987 @default.
• W2116875019 cites W2036272929 @default.
• W2116875019 cites W2037451740 @default.
• W2116875019 cites W2040403084 @default.
• W2116875019 cites W2047588523 @default.
• W2116875019 cites W2051673088 @default.
• W2116875019 cites W2052400036 @default.
• W2116875019 cites W2063709143 @default.
• W2116875019 cites W2073267769 @default.
• W2116875019 cites W2074128583 @default.
• W2116875019 cites W2077757600 @default.
• W2116875019 cites W2080437238 @default.
• W2116875019 cites W2084868140 @default.
• W2116875019 cites W2090362748 @default.
• W2116875019 cites W2091704828 @default.
• W2116875019 cites W2093702223 @default.
• W2116875019 cites W2095507267 @default.
• W2116875019 cites W2098309086 @default.
• W2116875019 cites W2099514866 @default.
• W2116875019 cites W2109356083 @default.
• W2116875019 cites W2109728760 @default.
• W2116875019 cites W2110874154 @default.
• W2116875019 cites W2111191860 @default.
• W2116875019 cites W2114333917 @default.
• W2116875019 cites W2116177557 @default.
• W2116875019 cites W2116297568 @default.
• W2116875019 cites W2117243579 @default.
• W2116875019 cites W2117576954 @default.
• W2116875019 cites W2119129185 @default.
• W2116875019 cites W2120852657 @default.
• W2116875019 cites W2121376459 @default.
• W2116875019 cites W2122340355 @default.
• W2116875019 cites W2122789412 @default.
• W2116875019 cites W2129160625 @default.
• W2116875019 cites W2129996961 @default.
• W2116875019 cites W2138599454 @default.
• W2116875019 cites W2139640181 @default.
• W2116875019 cites W2140125389 @default.
• W2116875019 cites W2140313980 @default.
• W2116875019 cites W2147343486 @default.
• W2116875019 cites W2149649063 @default.
• W2116875019 cites W2149832168 @default.
• W2116875019 cites W2149987040 @default.
• W2116875019 cites W2156150085 @default.
• W2116875019 cites W2167345725 @default.
• W2116875019 cites W2178121542 @default.
• W2116875019 cites W2975364463 @default.
• W2116875019 doi "https://doi.org/10.2147/dmso.s30005" @default.
• W2116875019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340112" @default.
• W2116875019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22563249" @default.
• W2116875019 hasPublicationYear "2012" @default.
• W2116875019 type Work @default.
• W2116875019 sameAs 2116875019 @default.
• W2116875019 citedByCount "16" @default.
• W2116875019 countsByYear W21168750192013 @default.
• W2116875019 countsByYear W21168750192015 @default.
• W2116875019 countsByYear W21168750192016 @default.
• W2116875019 countsByYear W21168750192018 @default.
• W2116875019 countsByYear W21168750192019 @default.
• W2116875019 countsByYear W21168750192020 @default.

• next