FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116876211> ?p ?o ?g. }

• W2116876211 endingPage "4902" @default.
• W2116876211 startingPage "4893" @default.
• W2116876211 abstract "A series of peptide nucleic acid (PNA) oligomers targeting the mdm2 oncogene mRNA has been tested for the ability to inhibit the growth of JAR cells. The effect of these PNAs on the cells was also reflected in reduced levels of the MDM2 protein and increased levels of the p53 tumor suppressor protein, which is negatively regulated by MDM2. Initially, PNA oligomers were delivered as DNA complexes with lipofectamine, but it was discovered that PNA conjugated to the DNA intercalator 9-aminoacridine (Acr) (Acr–PNA) could be effectively delivered to JAR cells (as well as to HeLa pLuc705 cells) even in the absence of a DNA carrier. Using such lipofectamine-delivered Acr–PNA conjugates, one PNA targeting a cryptic AUG initiation site was identified that at a concentration of 2 μM caused a reduction of MDM2 levels to ∼20% (but no reduction in mdm2 mRNA levels) and a 3-fold increase in p53 levels, whereas a 2-base mismatch control had no such effects. Furthermore, transcriptional activation by p53 was also increased (6-fold), and cell viability was reduced to 80%. Finally, this PNA acted cooperatively with camptothecin treatment both with regard to p53 activity induction as well as cell viability. Using this novel cell delivery system, we have identified a target on the mdm2 mRNA that appears sensitive to antisense inhibition by PNA and therefore could be used as a lead for further development of mdm2-targeted antisense (PNA and other) gene therapeutic anticancer drugs." @default.
• W2116876211 created "2016-06-24" @default.
• W2116876211 creator A5048806592 @default.
• W2116876211 creator A5071472584 @default.
• W2116876211 date "2004-09-07" @default.
• W2116876211 modified "2023-10-13" @default.
• W2116876211 title "Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates" @default.
• W2116876211 cites W1482077850 @default.
• W2116876211 cites W1491775880 @default.
• W2116876211 cites W1521801418 @default.
• W2116876211 cites W1549673200 @default.
• W2116876211 cites W1553897125 @default.
• W2116876211 cites W1558366281 @default.
• W2116876211 cites W1591281137 @default.
• W2116876211 cites W1600706591 @default.
• W2116876211 cites W1964304680 @default.
• W2116876211 cites W1985140517 @default.
• W2116876211 cites W2005551131 @default.
• W2116876211 cites W2010659535 @default.
• W2116876211 cites W2017492419 @default.
• W2116876211 cites W2032178581 @default.
• W2116876211 cites W2037725238 @default.
• W2116876211 cites W2040135588 @default.
• W2116876211 cites W2046386432 @default.
• W2116876211 cites W2052201137 @default.
• W2116876211 cites W2057921188 @default.
• W2116876211 cites W2061819045 @default.
• W2116876211 cites W2069060151 @default.
• W2116876211 cites W2075232816 @default.
• W2116876211 cites W2087160710 @default.
• W2116876211 cites W2093249575 @default.
• W2116876211 cites W2095014345 @default.
• W2116876211 cites W2099907467 @default.
• W2116876211 cites W2114103020 @default.
• W2116876211 cites W2130872480 @default.
• W2116876211 cites W2150079111 @default.
• W2116876211 cites W2169019691 @default.
• W2116876211 cites W2170494099 @default.
• W2116876211 cites W2991669885 @default.
• W2116876211 cites W39787558 @default.
• W2116876211 cites W2102398257 @default.
• W2116876211 doi "https://doi.org/10.1093/nar/gkh820" @default.
• W2116876211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/519114" @default.
• W2116876211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15371552" @default.
• W2116876211 hasPublicationYear "2004" @default.
• W2116876211 type Work @default.
• W2116876211 sameAs 2116876211 @default.
• W2116876211 citedByCount "44" @default.
• W2116876211 countsByYear W21168762112012 @default.
• W2116876211 countsByYear W21168762112014 @default.
• W2116876211 countsByYear W21168762112016 @default.
• W2116876211 countsByYear W21168762112017 @default.
• W2116876211 countsByYear W21168762112018 @default.
• W2116876211 countsByYear W21168762112019 @default.
• W2116876211 countsByYear W21168762112021 @default.
• W2116876211 countsByYear W21168762112023 @default.
• W2116876211 crossrefType "journal-article" @default.
• W2116876211 hasAuthorship W2116876211A5048806592 @default.
• W2116876211 hasAuthorship W2116876211A5071472584 @default.
• W2116876211 hasBestOaLocation W21168762111 @default.
• W2116876211 hasConcept C104317684 @default.
• W2116876211 hasConcept C1491633281 @default.
• W2116876211 hasConcept C153911025 @default.
• W2116876211 hasConcept C24107716 @default.
• W2116876211 hasConcept C2776192174 @default.
• W2116876211 hasConcept C2777343594 @default.
• W2116876211 hasConcept C2777366897 @default.
• W2116876211 hasConcept C2779682216 @default.
• W2116876211 hasConcept C2781018059 @default.
• W2116876211 hasConcept C29537977 @default.
• W2116876211 hasConcept C40767141 @default.
• W2116876211 hasConcept C49923114 @default.
• W2116876211 hasConcept C54009773 @default.
• W2116876211 hasConcept C55493867 @default.
• W2116876211 hasConcept C86803240 @default.
• W2116876211 hasConcept C92087593 @default.
• W2116876211 hasConcept C95444343 @default.
• W2116876211 hasConceptScore W2116876211C104317684 @default.
• W2116876211 hasConceptScore W2116876211C1491633281 @default.
• W2116876211 hasConceptScore W2116876211C153911025 @default.
• W2116876211 hasConceptScore W2116876211C24107716 @default.
• W2116876211 hasConceptScore W2116876211C2776192174 @default.
• W2116876211 hasConceptScore W2116876211C2777343594 @default.
• W2116876211 hasConceptScore W2116876211C2777366897 @default.
• W2116876211 hasConceptScore W2116876211C2779682216 @default.
• W2116876211 hasConceptScore W2116876211C2781018059 @default.
• W2116876211 hasConceptScore W2116876211C29537977 @default.
• W2116876211 hasConceptScore W2116876211C40767141 @default.
• W2116876211 hasConceptScore W2116876211C49923114 @default.
• W2116876211 hasConceptScore W2116876211C54009773 @default.
• W2116876211 hasConceptScore W2116876211C55493867 @default.
• W2116876211 hasConceptScore W2116876211C86803240 @default.
• W2116876211 hasConceptScore W2116876211C92087593 @default.
• W2116876211 hasConceptScore W2116876211C95444343 @default.
• W2116876211 hasIssue "16" @default.
• W2116876211 hasLocation W21168762111 @default.
• W2116876211 hasLocation W21168762112 @default.
• W2116876211 hasLocation W21168762113 @default.

• next