FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116881176> ?p ?o ?g. }

• W2116881176 endingPage "2779" @default.
• W2116881176 startingPage "2769" @default.
• W2116881176 abstract "Locally projecting inhibitory interneurons play a crucial role in the patterning and timing of network activity. However, because of their relative inaccessibility, little is known about their development or incorporation into circuits. In this report we demonstrate that the GABAergic R-interneuron circuit undergoes a reorganization in the chick embryo spinal cord between embryonic days 8 and 15 (E8 and E15). R-interneurons receive synaptic input from and project back to motoneurons. By stimulating motoneurons projecting in one ventral root and recording the disynaptic response from motoneurons in adjacent segments, we show that the output of the R-interneuron circuit is reorganized during development. After stimulation of the LS2 ventral root, disynaptic responses observed in whole cell recordings became more common and stronger for LS3 motoneurons and less common for the more distant LS4 motoneurons from E8 to E10. Optical studies demonstrated that R-interneurons activated by LS2 stimulation were restricted to the LS2 segment and had a small glutamatergic component at both E8 and E10, but that more R-interneurons were activated within the segment by E10. The recruitment of more LS2 R-interneurons at E10 is likely to contribute to stronger projections to LS3 motoneurons, but the fact that fewer LS4 motoneurons receive this input is more consistent with a functional refinement of the more distant projection of the GABAergic R-interneuron. Interestingly, this pattern of reorganization was not observed throughout the rostrocaudal extent of the cord, introducing the possibility that refinement could serve to remove connections between functionally unrelated interneurons and motoneurons." @default.
• W2116881176 created "2016-06-24" @default.
• W2116881176 creator A5012411868 @default.
• W2116881176 creator A5013996110 @default.
• W2116881176 creator A5084250577 @default.
• W2116881176 creator A5089130857 @default.
• W2116881176 date "2007-04-01" @default.
• W2116881176 modified "2023-09-23" @default.
• W2116881176 title "Developmental Reorganization of the Output of a GABAergic Interneuronal Circuit" @default.
• W2116881176 cites W1521233300 @default.
• W2116881176 cites W1571068599 @default.
• W2116881176 cites W1600494696 @default.
• W2116881176 cites W1612805808 @default.
• W2116881176 cites W1632057558 @default.
• W2116881176 cites W1659359944 @default.
• W2116881176 cites W1953807893 @default.
• W2116881176 cites W1968010523 @default.
• W2116881176 cites W1969958128 @default.
• W2116881176 cites W1974557278 @default.
• W2116881176 cites W1976013316 @default.
• W2116881176 cites W1977756935 @default.
• W2116881176 cites W1980462929 @default.
• W2116881176 cites W1981758324 @default.
• W2116881176 cites W1986081802 @default.
• W2116881176 cites W1988476326 @default.
• W2116881176 cites W2004098242 @default.
• W2116881176 cites W2006133841 @default.
• W2116881176 cites W2009697267 @default.
• W2116881176 cites W2012409876 @default.
• W2116881176 cites W2013639040 @default.
• W2116881176 cites W2015332713 @default.
• W2116881176 cites W2033397150 @default.
• W2116881176 cites W2033750790 @default.
• W2116881176 cites W2034572289 @default.
• W2116881176 cites W2035280100 @default.
• W2116881176 cites W2039178370 @default.
• W2116881176 cites W2039607621 @default.
• W2116881176 cites W2057364388 @default.
• W2116881176 cites W2061174637 @default.
• W2116881176 cites W2061506972 @default.
• W2116881176 cites W2064022977 @default.
• W2116881176 cites W2067168460 @default.
• W2116881176 cites W2073929966 @default.
• W2116881176 cites W2077862802 @default.
• W2116881176 cites W2082170249 @default.
• W2116881176 cites W2087457097 @default.
• W2116881176 cites W2088475496 @default.
• W2116881176 cites W2088703515 @default.
• W2116881176 cites W2092885114 @default.
• W2116881176 cites W2093548768 @default.
• W2116881176 cites W2093645910 @default.
• W2116881176 cites W2100728233 @default.
• W2116881176 cites W2106751693 @default.
• W2116881176 cites W2115167440 @default.
• W2116881176 cites W2119405032 @default.
• W2116881176 cites W2121455138 @default.
• W2116881176 cites W2121674463 @default.
• W2116881176 cites W2125266098 @default.
• W2116881176 cites W2128966898 @default.
• W2116881176 cites W2130549783 @default.
• W2116881176 cites W2140034535 @default.
• W2116881176 cites W2142959939 @default.
• W2116881176 cites W2144491174 @default.
• W2116881176 cites W2150497419 @default.
• W2116881176 cites W2166989009 @default.
• W2116881176 cites W2169713434 @default.
• W2116881176 cites W2243324492 @default.
• W2116881176 cites W2243751281 @default.
• W2116881176 cites W2276213602 @default.
• W2116881176 cites W2291519035 @default.
• W2116881176 cites W2318472109 @default.
• W2116881176 cites W2397470456 @default.
• W2116881176 cites W2409015817 @default.
• W2116881176 cites W2415029438 @default.
• W2116881176 cites W2437542888 @default.
• W2116881176 doi "https://doi.org/10.1152/jn.01324.2006" @default.
• W2116881176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17251359" @default.
• W2116881176 hasPublicationYear "2007" @default.
• W2116881176 type Work @default.
• W2116881176 sameAs 2116881176 @default.
• W2116881176 citedByCount "6" @default.
• W2116881176 countsByYear W21168811762013 @default.
• W2116881176 crossrefType "journal-article" @default.
• W2116881176 hasAuthorship W2116881176A5012411868 @default.
• W2116881176 hasAuthorship W2116881176A5013996110 @default.
• W2116881176 hasAuthorship W2116881176A5084250577 @default.
• W2116881176 hasAuthorship W2116881176A5089130857 @default.
• W2116881176 hasConcept C105702510 @default.
• W2116881176 hasConcept C169760540 @default.
• W2116881176 hasConcept C170493617 @default.
• W2116881176 hasConcept C17077164 @default.
• W2116881176 hasConcept C24998067 @default.
• W2116881176 hasConcept C2779177108 @default.
• W2116881176 hasConcept C2779296341 @default.
• W2116881176 hasConcept C2780648746 @default.
• W2116881176 hasConcept C2780775167 @default.
• W2116881176 hasConcept C55493867 @default.
• W2116881176 hasConcept C61174792 @default.

• next