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• W2116881722 endingPage "289" @default.
• W2116881722 startingPage "279" @default.
• W2116881722 abstract "Because both basal and postmethionine load hyperhomocysteinemia are correlated with vascular disease, there is a need to determine the underlying causes. Although deficiencies of folate, cobalamin, and pyridoxine have all been implicated there are difficulties in distinguishing among them. The objective was to determine the changes in total homocysteine, cystathionine, and other methionine, one carbon- and tryptophan-related metabolites in rats with dietary induced folate or pyridoxine deficiency and cobalamin analogue induced deficiency. Pyridoxine-deficient diet (0 mg/kg) increased basal serum cystathionine levels (14 fold) after 51 days with a smaller increase in basal total homocysteine. Diets with 0 to 1.5 mg/kg pyridoxine also caused graded increases in serum cystathionine. Total homocysteine and cystathionine were markedly increased postmethionine load in the pyridoxine deficient rats as compared to the control, folate-, or cobalamin-deficient rats. Folate- and cobalamin-deficient rats had marked increases in basal total homocysteine and moderate increases in basal cystathionine, but the increments in postmethionine load values were not different than control. Pyridoxine deficiency decreased liver serine transhydroxymethylase activity to 6%. Post-tryptophan load serum xanthurenic acid was equal in cobalamin- and pyridoxine-deficient rats. Serum quinolinic acid was increased only in the cobalamin-deficient rats. Plasma pyridoxal-5′-phosphate levels were not as sensitive as serum cystathionine in pyridoxine deficiency. Basal and postmethionine load serum cystathionine levels are very sensitive in detecting pyridoxine deficiency and will be useful when determining the cause of clinical hyperhomocysteinemia." @default.
• W2116881722 created "2016-06-24" @default.
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• W2116881722 date "1997-05-01" @default.
• W2116881722 modified "2023-10-10" @default.
• W2116881722 title "Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats" @default.
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• W2116881722 doi "https://doi.org/10.1016/s0955-2863(97)89666-0" @default.
• W2116881722 hasPublicationYear "1997" @default.
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