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• W2116892066 endingPage "3422" @default.
• W2116892066 startingPage "3415" @default.
• W2116892066 abstract "ABSTRACT In a screen for mutants that display synthetic lethal interaction with hpr1 Δ, a hyperrecombination mutant of Saccharomyces cerevisiae , we have isolated a novel cold-sensitive allele of the acetyl coenzyme A (CoA) carboxylase gene, acc1 cs , encoding the rate-limiting enzyme of fatty acid synthesis. The synthetic lethal phenotype of the acc1 cs hpr1 Δ double mutant was only partially complemented by exogenous fatty acids. hpr1 Δ was also synthetically lethal with a previously isolated, temperature-sensitive allele of ACC1 , mtr7 (mRNA transport), indicating that the lethality of the acc1 cs hpr1 Δ double mutant was not allele specific. The basis for the interaction between conditional acc1 alleles and hpr1 Δ was investigated in more detail. In the hpr1 Δ mutant background, acetyl-CoA carboxylase enzyme activity was reduced about 15-fold and steady-state levels of biotinylated Acc1p and ACC1 mRNA were reduced 2-fold. The reduced Acc1p activity in hpr1 Δ cells, however, did not result in an altered lipid or fatty acid composition of the mutant membranes but rendered cells hypersensitive to soraphen A, an inhibitor of Acc1p. Similar to mtr7 , hpr1 Δ and acc1 cs mutant cells displayed a defect in nuclear export of polyadenylated RNA. Oversized transcripts were detected in hpr1 Δ, and rRNA processing was disturbed, but pre-mRNA splicing appeared wild type. Surprisingly, the transport defect of hpr1 Δ and acc1 cs mutant cells was accompanied by an altered ring-shaped structure of the nucleolus. These observations suggest that the basis for the synthetic lethal interaction between hpr1 Δ and acc1 may lie in a functional overlap of the two mutations in nuclear poly(A) + RNA production and export that results in an altered structure of the nucleolus." @default.
• W2116892066 created "2016-06-24" @default.
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• W2116892066 date "1999-05-01" @default.
• W2116892066 modified "2023-10-13" @default.
• W2116892066 title "The <i>Saccharomyces cerevisiae</i> Hyperrecombination Mutant <i>hpr1</i>Δ Is Synthetically Lethal with Two Conditional Alleles of the Acetyl Coenzyme A Carboxylase Gene and Causes a Defect in Nuclear Export of Polyadenylated RNA" @default.
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• W2116892066 doi "https://doi.org/10.1128/mcb.19.5.3415" @default.
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