FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116899741> ?p ?o ?g. }

• W2116899741 endingPage "4776" @default.
• W2116899741 startingPage "4767" @default.
• W2116899741 abstract "The attenuated S. typhimurium SL3261 (aroA) strain causes mild infections in BALB/c mice. We were able to exacerbate the disease by administering anti-interleukin-12 (IL-12) antibodies, resulting in bacterial counts in the spleens and livers of anti-IL-12-treated mice that were 10- to 100-fold higher than the ones normally observed in premortem mice; yet the animals showed only mild signs of illness. Nevertheless, they eventually died of a slow, progressive disease. Mice infected with salmonellae become hypersusceptible to endotoxin. We found that IL-12 neutralization prevented the death of infected mice following subcutaneous injection of lipopolysaccharide. Granulomatous lesions developed in the spleens and livers of control animals, as opposed to a widespread infiltration of mononuclear cells seen in the organs of anti-IL-12-treated mice. In the latter (heavily infected), salmonellae were seen within mononuclear cells, indicating an impairment of the bactericidal or bacteriostatic ability of the phagocytes in the absence of biologically active IL-12. Gamma interferon (IFN-gamma) levels were reduced in the sera and tissue homogenates from anti-IL-12-treated mice compared to those in control animals. Furthermore, fluorescence-activated cell sorter analysis on spleen cells showed that IL-12 neutralization impaired the upregulation of I-Ad/I-Ed antigens on macrophages from infected mice. Inducible nitric oxide synthase and IFN-gamma mRNA production was down-regulated in anti-IL-12-treated mice, which also showed an increased production of IL-10 mRNA and a decrease in nitric oxide synthase activity in the tissues. Administration of recombinant IFN-gamma to anti-IL-12-treated mice was able to restore host resistance, granuloma formation, and expression of major histocompatibility complex class II antigens in F4/80(+) and CD11b+ spleen cells." @default.
• W2116899741 created "2016-06-24" @default.
• W2116899741 creator A5005117084 @default.
• W2116899741 creator A5032122956 @default.
• W2116899741 creator A5041015903 @default.
• W2116899741 creator A5047404265 @default.
• W2116899741 creator A5067543504 @default.
• W2116899741 creator A5070935391 @default.
• W2116899741 creator A5073865405 @default.
• W2116899741 creator A5089626295 @default.
• W2116899741 date "1998-10-01" @default.
• W2116899741 modified "2023-10-14" @default.
• W2116899741 title "Interleukin-12 Is Required for Control of the Growth of Attenuated Aromatic-Compound-Dependent Salmonellae in BALB/c Mice: Role of Gamma Interferon and Macrophage Activation" @default.
• W2116899741 cites W101818886 @default.
• W2116899741 cites W117547646 @default.
• W2116899741 cites W1480063099 @default.
• W2116899741 cites W1495915055 @default.
• W2116899741 cites W1546596164 @default.
• W2116899741 cites W1585156290 @default.
• W2116899741 cites W1857521174 @default.
• W2116899741 cites W1910689154 @default.
• W2116899741 cites W1916462614 @default.
• W2116899741 cites W1932670979 @default.
• W2116899741 cites W1935228498 @default.
• W2116899741 cites W1942332477 @default.
• W2116899741 cites W1958035891 @default.
• W2116899741 cites W1964323924 @default.
• W2116899741 cites W1973535328 @default.
• W2116899741 cites W1979968600 @default.
• W2116899741 cites W1995104906 @default.
• W2116899741 cites W2017684091 @default.
• W2116899741 cites W2026287371 @default.
• W2116899741 cites W2028500185 @default.
• W2116899741 cites W2040294588 @default.
• W2116899741 cites W2042048278 @default.
• W2116899741 cites W2045834057 @default.
• W2116899741 cites W2053148124 @default.
• W2116899741 cites W2062922499 @default.
• W2116899741 cites W2071099576 @default.
• W2116899741 cites W2104439753 @default.
• W2116899741 cites W2109626244 @default.
• W2116899741 cites W2110761918 @default.
• W2116899741 cites W2115065580 @default.
• W2116899741 cites W2125042173 @default.
• W2116899741 cites W2128850040 @default.
• W2116899741 cites W2131941390 @default.
• W2116899741 cites W2134768631 @default.
• W2116899741 cites W2136333247 @default.
• W2116899741 cites W2137279806 @default.
• W2116899741 cites W2153552716 @default.
• W2116899741 cites W2154218327 @default.
• W2116899741 cites W2156041007 @default.
• W2116899741 cites W2156664829 @default.
• W2116899741 cites W2158920308 @default.
• W2116899741 cites W2161485037 @default.
• W2116899741 cites W2169318719 @default.
• W2116899741 cites W2171231066 @default.
• W2116899741 cites W2416018951 @default.
• W2116899741 cites W4231581694 @default.
• W2116899741 cites W4250647025 @default.
• W2116899741 cites W87420729 @default.
• W2116899741 doi "https://doi.org/10.1128/iai.66.10.4767-4776.1998" @default.
• W2116899741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108588" @default.
• W2116899741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9746577" @default.
• W2116899741 hasPublicationYear "1998" @default.
• W2116899741 type Work @default.
• W2116899741 sameAs 2116899741 @default.
• W2116899741 citedByCount "142" @default.
• W2116899741 countsByYear W21168997412012 @default.
• W2116899741 countsByYear W21168997412013 @default.
• W2116899741 countsByYear W21168997412014 @default.
• W2116899741 countsByYear W21168997412015 @default.
• W2116899741 countsByYear W21168997412016 @default.
• W2116899741 countsByYear W21168997412017 @default.
• W2116899741 countsByYear W21168997412018 @default.
• W2116899741 countsByYear W21168997412019 @default.
• W2116899741 countsByYear W21168997412020 @default.
• W2116899741 countsByYear W21168997412021 @default.
• W2116899741 countsByYear W21168997412022 @default.
• W2116899741 countsByYear W21168997412023 @default.
• W2116899741 crossrefType "journal-article" @default.
• W2116899741 hasAuthorship W2116899741A5005117084 @default.
• W2116899741 hasAuthorship W2116899741A5032122956 @default.
• W2116899741 hasAuthorship W2116899741A5041015903 @default.
• W2116899741 hasAuthorship W2116899741A5047404265 @default.
• W2116899741 hasAuthorship W2116899741A5067543504 @default.
• W2116899741 hasAuthorship W2116899741A5070935391 @default.
• W2116899741 hasAuthorship W2116899741A5073865405 @default.
• W2116899741 hasAuthorship W2116899741A5089626295 @default.
• W2116899741 hasBestOaLocation W21168997411 @default.
• W2116899741 hasConcept C134018914 @default.
• W2116899741 hasConcept C19702531 @default.
• W2116899741 hasConcept C202751555 @default.
• W2116899741 hasConcept C203014093 @default.
• W2116899741 hasConcept C2776529007 @default.
• W2116899741 hasConcept C2777622882 @default.
• W2116899741 hasConcept C2778690821 @default.
• W2116899741 hasConcept C2778754761 @default.

• next