Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116903950> ?p ?o ?g. }
- W2116903950 endingPage "8" @default.
- W2116903950 startingPage "1" @default.
- W2116903950 abstract "It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity. This paper first describes the expression of the vasoconstrictive arm of RAS components in the brain as well as their physiological and pathophysiological significance. It then focus on the (pro)renin receptor (PRR), a newly discovered component of the RAS which has a high level in the brain. We review the role of prorenin and PRR in peripheral organs and emphasize the involvement of brain PRR in the pathogenesis of hypertension. Some future perspectives in PRR research are heighted with respect to novel therapeutic target for the treatment of hypertension and other cardiovascular diseases." @default.
- W2116903950 created "2016-06-24" @default.
- W2116903950 creator A5008389654 @default.
- W2116903950 creator A5012718037 @default.
- W2116903950 creator A5044239371 @default.
- W2116903950 creator A5081036799 @default.
- W2116903950 date "2012-01-01" @default.
- W2116903950 modified "2023-10-17" @default.
- W2116903950 title "The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?" @default.
- W2116903950 cites W1547101270 @default.
- W2116903950 cites W1612490102 @default.
- W2116903950 cites W1943576895 @default.
- W2116903950 cites W1964934996 @default.
- W2116903950 cites W1966697314 @default.
- W2116903950 cites W1966973320 @default.
- W2116903950 cites W1967742032 @default.
- W2116903950 cites W1973060066 @default.
- W2116903950 cites W1974133475 @default.
- W2116903950 cites W1975211903 @default.
- W2116903950 cites W1984635274 @default.
- W2116903950 cites W1991841545 @default.
- W2116903950 cites W1993407749 @default.
- W2116903950 cites W1994259586 @default.
- W2116903950 cites W1998564842 @default.
- W2116903950 cites W1998959104 @default.
- W2116903950 cites W2003350706 @default.
- W2116903950 cites W2003442673 @default.
- W2116903950 cites W2017023544 @default.
- W2116903950 cites W2019310839 @default.
- W2116903950 cites W2026857465 @default.
- W2116903950 cites W2040054030 @default.
- W2116903950 cites W2042592058 @default.
- W2116903950 cites W2046571833 @default.
- W2116903950 cites W2052408753 @default.
- W2116903950 cites W2055044330 @default.
- W2116903950 cites W2056030855 @default.
- W2116903950 cites W2060725702 @default.
- W2116903950 cites W2062477957 @default.
- W2116903950 cites W2062993324 @default.
- W2116903950 cites W2065415433 @default.
- W2116903950 cites W2067946831 @default.
- W2116903950 cites W2073853285 @default.
- W2116903950 cites W2075228337 @default.
- W2116903950 cites W2080670526 @default.
- W2116903950 cites W2081831710 @default.
- W2116903950 cites W2083898560 @default.
- W2116903950 cites W2089347102 @default.
- W2116903950 cites W2089744665 @default.
- W2116903950 cites W2090374142 @default.
- W2116903950 cites W2099238761 @default.
- W2116903950 cites W2106039672 @default.
- W2116903950 cites W2107151854 @default.
- W2116903950 cites W2108242869 @default.
- W2116903950 cites W2116520916 @default.
- W2116903950 cites W2119056313 @default.
- W2116903950 cites W2126148683 @default.
- W2116903950 cites W2126637481 @default.
- W2116903950 cites W2126802792 @default.
- W2116903950 cites W2135441143 @default.
- W2116903950 cites W2136553948 @default.
- W2116903950 cites W2136964355 @default.
- W2116903950 cites W2139181447 @default.
- W2116903950 cites W2142063013 @default.
- W2116903950 cites W2142538245 @default.
- W2116903950 cites W2160598948 @default.
- W2116903950 cites W2161143063 @default.
- W2116903950 cites W2164232039 @default.
- W2116903950 cites W2165800391 @default.
- W2116903950 cites W2166467005 @default.
- W2116903950 cites W2167422964 @default.
- W2116903950 cites W2168038162 @default.
- W2116903950 cites W2168101902 @default.
- W2116903950 cites W2170415924 @default.
- W2116903950 cites W2172465647 @default.
- W2116903950 cites W2189121400 @default.
- W2116903950 cites W2260580680 @default.
- W2116903950 cites W2265010546 @default.
- W2116903950 cites W392903149 @default.
- W2116903950 cites W4246595030 @default.
- W2116903950 doi "https://doi.org/10.1155/2012/290635" @default.
- W2116903950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3536329" @default.
- W2116903950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23316344" @default.
- W2116903950 hasPublicationYear "2012" @default.
- W2116903950 type Work @default.
- W2116903950 sameAs 2116903950 @default.
- W2116903950 citedByCount "37" @default.
- W2116903950 countsByYear W21169039502013 @default.
- W2116903950 countsByYear W21169039502014 @default.
- W2116903950 countsByYear W21169039502015 @default.
- W2116903950 countsByYear W21169039502016 @default.
- W2116903950 countsByYear W21169039502017 @default.
- W2116903950 countsByYear W21169039502018 @default.
- W2116903950 countsByYear W21169039502019 @default.
- W2116903950 countsByYear W21169039502020 @default.
- W2116903950 countsByYear W21169039502021 @default.
- W2116903950 countsByYear W21169039502022 @default.
- W2116903950 countsByYear W21169039502023 @default.
- W2116903950 crossrefType "journal-article" @default.