FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116932393> ?p ?o ?g. }

• W2116932393 endingPage "1513" @default.
• W2116932393 startingPage "1504" @default.
• W2116932393 abstract "Background. Recent trials report the short-term efficacy of tenofovir-based pre-exposure prophylaxis (PrEP) for prevention of human immunodeficiency virus (HIV) infection. PrEP’s long-term impact on patient outcomes, population-level transmission, and cost-effectiveness remains unknown. Methods. We linked data from recent trials to a computer model of HIV acquisition, screening, and care to project lifetime HIV risk, life expectancy (LE), costs, and cost-effectiveness, using 2 PrEP-related strategies among heterosexual South African women: (1) women receiving no PrEP and (2) women not receiving PrEP (a tenofovir-based vaginal microbicide). We used a South African clinical cohort and published data to estimate population demographic characteristics, age-adjusted incidence of HIV infection, and HIV natural history and treatment parameters. Baseline PrEP efficacy (percentage reduction in HIV transmission) was 39% at a monthly cost of $5 per woman. Alternative parameter values were examined in sensitivity analyses. Results. Among South African women, PrEP reduced mean lifetime HIV risk from 40% to 27% and increased population discounted (undiscounted) LE from 22.51 (41.66) to 23.48 (44.48) years. Lifetime costs of care increased from $7280 to $9890 per woman, resulting in an incremental cost-effectiveness ratio of $2700/year of life saved, and may, under optimistic assumptions, achieve cost savings. Under baseline HIV infection incidence assumptions, PrEP was not cost saving, even assuming an efficacy >60% and a cost <$1. At an HIV infection incidence of 9.1%/year, PrEP achieved cost savings at efficacies ≥50%. Conclusions. PrEP in South African women is very cost-effective by South African standards, conferring excellent value under virtually all plausible data scenarios. Although optimistic assumptions would be required to achieve cost savings, these represent important benchmarks for future PrEP study design." @default.
• W2116932393 created "2016-06-24" @default.
• W2116932393 creator A5002686651 @default.
• W2116932393 creator A5002712707 @default.
• W2116932393 creator A5019522183 @default.
• W2116932393 creator A5025150770 @default.
• W2116932393 creator A5039983859 @default.
• W2116932393 creator A5054551527 @default.
• W2116932393 creator A5062889731 @default.
• W2116932393 creator A5064614188 @default.
• W2116932393 creator A5074313423 @default.
• W2116932393 creator A5078419406 @default.
• W2116932393 date "2012-04-03" @default.
• W2116932393 modified "2023-10-13" @default.
• W2116932393 title "The Cost-effectiveness of Pre-Exposure Prophylaxis for HIV Infection in South African Women" @default.
• W2116932393 cites W1967223378 @default.
• W2116932393 cites W1972935005 @default.
• W2116932393 cites W2003932134 @default.
• W2116932393 cites W2007856240 @default.
• W2116932393 cites W2038464827 @default.
• W2116932393 cites W2038662816 @default.
• W2116932393 cites W2040386767 @default.
• W2116932393 cites W2047690132 @default.
• W2116932393 cites W2063409115 @default.
• W2116932393 cites W2063420196 @default.
• W2116932393 cites W2065464437 @default.
• W2116932393 cites W2067141635 @default.
• W2116932393 cites W2070629478 @default.
• W2116932393 cites W2072615429 @default.
• W2116932393 cites W2084063844 @default.
• W2116932393 cites W2088008322 @default.
• W2116932393 cites W2101465292 @default.
• W2116932393 cites W2102136130 @default.
• W2116932393 cites W2103920597 @default.
• W2116932393 cites W2108259145 @default.
• W2116932393 cites W2110937893 @default.
• W2116932393 cites W2114267004 @default.
• W2116932393 cites W2121288293 @default.
• W2116932393 cites W2121617938 @default.
• W2116932393 cites W2126268386 @default.
• W2116932393 cites W2144198686 @default.
• W2116932393 cites W2145352823 @default.
• W2116932393 cites W2146634980 @default.
• W2116932393 cites W2158513952 @default.
• W2116932393 cites W2162453648 @default.
• W2116932393 cites W2162761942 @default.
• W2116932393 cites W2171141994 @default.
• W2116932393 doi "https://doi.org/10.1093/cid/cis225" @default.
• W2116932393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3334365" @default.
• W2116932393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22474224" @default.
• W2116932393 hasPublicationYear "2012" @default.
• W2116932393 type Work @default.
• W2116932393 sameAs 2116932393 @default.
• W2116932393 citedByCount "88" @default.
• W2116932393 countsByYear W21169323932012 @default.
• W2116932393 countsByYear W21169323932013 @default.
• W2116932393 countsByYear W21169323932014 @default.
• W2116932393 countsByYear W21169323932015 @default.
• W2116932393 countsByYear W21169323932016 @default.
• W2116932393 countsByYear W21169323932017 @default.
• W2116932393 countsByYear W21169323932018 @default.
• W2116932393 countsByYear W21169323932019 @default.
• W2116932393 countsByYear W21169323932020 @default.
• W2116932393 countsByYear W21169323932021 @default.
• W2116932393 countsByYear W21169323932022 @default.
• W2116932393 crossrefType "journal-article" @default.
• W2116932393 hasAuthorship W2116932393A5002686651 @default.
• W2116932393 hasAuthorship W2116932393A5002712707 @default.
• W2116932393 hasAuthorship W2116932393A5019522183 @default.
• W2116932393 hasAuthorship W2116932393A5025150770 @default.
• W2116932393 hasAuthorship W2116932393A5039983859 @default.
• W2116932393 hasAuthorship W2116932393A5054551527 @default.
• W2116932393 hasAuthorship W2116932393A5062889731 @default.
• W2116932393 hasAuthorship W2116932393A5064614188 @default.
• W2116932393 hasAuthorship W2116932393A5074313423 @default.
• W2116932393 hasAuthorship W2116932393A5078419406 @default.
• W2116932393 hasBestOaLocation W21169323931 @default.
• W2116932393 hasConcept C112930515 @default.
• W2116932393 hasConcept C119599485 @default.
• W2116932393 hasConcept C120665830 @default.
• W2116932393 hasConcept C121332964 @default.
• W2116932393 hasConcept C126322002 @default.
• W2116932393 hasConcept C127413603 @default.
• W2116932393 hasConcept C133925201 @default.
• W2116932393 hasConcept C144024400 @default.
• W2116932393 hasConcept C149923435 @default.
• W2116932393 hasConcept C197746943 @default.
• W2116932393 hasConcept C203014093 @default.
• W2116932393 hasConcept C2776939746 @default.
• W2116932393 hasConcept C2776983459 @default.
• W2116932393 hasConcept C2779496540 @default.
• W2116932393 hasConcept C2908647359 @default.
• W2116932393 hasConcept C3013748606 @default.
• W2116932393 hasConcept C3019080777 @default.
• W2116932393 hasConcept C61511704 @default.
• W2116932393 hasConcept C71924100 @default.
• W2116932393 hasConcept C72563966 @default.
• W2116932393 hasConcept C761482 @default.

• next