FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116948265> ?p ?o ?g. }

• W2116948265 endingPage "199" @default.
• W2116948265 startingPage "188" @default.
• W2116948265 abstract "Abstract It has been hypothesized that neuroinflammation triggered during brain development can alter brain functions later in life. We investigated the contribution of inflammation to the alteration of normal brain circuitries in the context of neuroexcitotoxicity following neonatal ventral hippocampal lesions in rats with ibotenic acid, an NMDA glutamate receptor agonist. Excitotoxic ibotenic acid lesions led to a significant and persistent astrogliosis and microglial activation, associated with the production of inflammatory mediators. This response was accompanied by a significant increase in metabotropic glutamate receptor type 5 (mGluR5) expression within two distinct neuroinflammatory cell types; astrocytes and microglia. The participation of inflammation to the neurotoxin‐induced lesion was further supported by the prevention of hippocampal neuronal loss, glial mGluR5 expression and some of the behavioral perturbations associated to the excitotoxic lesion by concurrent anti‐inflammatory treatment with minocycline. These results indicate that neuroinflammation significantly contributes to long‐lasting excitotoxic effects of the neurotoxin and to some behavioral phenotypes associated with this model. Thus, the control of the inflammatory response may prevent the deleterious effects of excitotoxic processes that are triggered during brain development, limiting the risk to develop some of the behavioral manifestations related to these processes in adulthood. © 2010 Wiley‐Liss, Inc." @default.
• W2116948265 created "2016-06-24" @default.
• W2116948265 creator A5011686386 @default.
• W2116948265 creator A5024580674 @default.
• W2116948265 creator A5043324295 @default.
• W2116948265 creator A5060615635 @default.
• W2116948265 creator A5065146020 @default.
• W2116948265 creator A5078393119 @default.
• W2116948265 creator A5084779160 @default.
• W2116948265 creator A5091395921 @default.
• W2116948265 date "2010-12-01" @default.
• W2116948265 modified "2023-10-16" @default.
• W2116948265 title "Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions" @default.
• W2116948265 cites W1485896673 @default.
• W2116948265 cites W1504788794 @default.
• W2116948265 cites W1916247363 @default.
• W2116948265 cites W1965245442 @default.
• W2116948265 cites W1967693560 @default.
• W2116948265 cites W1971474634 @default.
• W2116948265 cites W1973392168 @default.
• W2116948265 cites W1978185926 @default.
• W2116948265 cites W1983686907 @default.
• W2116948265 cites W1993589138 @default.
• W2116948265 cites W1999686542 @default.
• W2116948265 cites W2003869950 @default.
• W2116948265 cites W2012245779 @default.
• W2116948265 cites W2014273178 @default.
• W2116948265 cites W2018877420 @default.
• W2116948265 cites W2018922612 @default.
• W2116948265 cites W2022381785 @default.
• W2116948265 cites W2022405336 @default.
• W2116948265 cites W2024922324 @default.
• W2116948265 cites W2027685051 @default.
• W2116948265 cites W2027985523 @default.
• W2116948265 cites W2031108466 @default.
• W2116948265 cites W2034003277 @default.
• W2116948265 cites W2039392338 @default.
• W2116948265 cites W2040088974 @default.
• W2116948265 cites W2062240346 @default.
• W2116948265 cites W2064836594 @default.
• W2116948265 cites W2065940220 @default.
• W2116948265 cites W2069769925 @default.
• W2116948265 cites W2076644456 @default.
• W2116948265 cites W2080206459 @default.
• W2116948265 cites W2087685632 @default.
• W2116948265 cites W2093950888 @default.
• W2116948265 cites W2099375566 @default.
• W2116948265 cites W2102446194 @default.
• W2116948265 cites W2103738800 @default.
• W2116948265 cites W2113617025 @default.
• W2116948265 cites W2117465944 @default.
• W2116948265 cites W2126300446 @default.
• W2116948265 cites W2143217444 @default.
• W2116948265 cites W2144508667 @default.
• W2116948265 cites W2148726772 @default.
• W2116948265 cites W2150224367 @default.
• W2116948265 cites W2150626397 @default.
• W2116948265 cites W2158230836 @default.
• W2116948265 cites W2161584310 @default.
• W2116948265 doi "https://doi.org/10.1002/glia.21086" @default.
• W2116948265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3983848" @default.
• W2116948265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21125661" @default.
• W2116948265 hasPublicationYear "2010" @default.
• W2116948265 type Work @default.
• W2116948265 sameAs 2116948265 @default.
• W2116948265 citedByCount "62" @default.
• W2116948265 countsByYear W21169482652012 @default.
• W2116948265 countsByYear W21169482652013 @default.
• W2116948265 countsByYear W21169482652014 @default.
• W2116948265 countsByYear W21169482652015 @default.
• W2116948265 countsByYear W21169482652016 @default.
• W2116948265 countsByYear W21169482652017 @default.
• W2116948265 countsByYear W21169482652018 @default.
• W2116948265 countsByYear W21169482652019 @default.
• W2116948265 countsByYear W21169482652020 @default.
• W2116948265 countsByYear W21169482652021 @default.
• W2116948265 countsByYear W21169482652022 @default.
• W2116948265 countsByYear W21169482652023 @default.
• W2116948265 crossrefType "journal-article" @default.
• W2116948265 hasAuthorship W2116948265A5011686386 @default.
• W2116948265 hasAuthorship W2116948265A5024580674 @default.
• W2116948265 hasAuthorship W2116948265A5043324295 @default.
• W2116948265 hasAuthorship W2116948265A5060615635 @default.
• W2116948265 hasAuthorship W2116948265A5065146020 @default.
• W2116948265 hasAuthorship W2116948265A5078393119 @default.
• W2116948265 hasAuthorship W2116948265A5084779160 @default.
• W2116948265 hasAuthorship W2116948265A5091395921 @default.
• W2116948265 hasBestOaLocation W21169482652 @default.
• W2116948265 hasConcept C134018914 @default.
• W2116948265 hasConcept C142724271 @default.
• W2116948265 hasConcept C148762608 @default.
• W2116948265 hasConcept C169760540 @default.
• W2116948265 hasConcept C170493617 @default.
• W2116948265 hasConcept C203014093 @default.
• W2116948265 hasConcept C2776914184 @default.
• W2116948265 hasConcept C2777681179 @default.
• W2116948265 hasConcept C2777682930 @default.
• W2116948265 hasConcept C2779830541 @default.

• next