FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116957788> ?p ?o ?g. }

• W2116957788 endingPage "1596" @default.
• W2116957788 startingPage "1589" @default.
• W2116957788 abstract "Concurrent isomerization of the ethyl, 2-ethoxyethyl, 2,2-dichloroethyl and 2,2,2-trichloroethyl esters of uridine 3′-phosphate to their 2′-counterparts and cleavage to uridine 2′,3′-cyclic phosphate have been studied over a wide pH-range (H0 = –0.2 to pH 9) at 363.2 K. The buffer-independent pH-rate profiles obtained show involvement of four distinct kinetic terms in the cleavage reaction, viz. dependence of rate on [H+][SH], [SH], [S–] and [S–][H+]–1 (S– denotes the diester monoanion). The βlg values (lg = leaving group) for the partial reactions are –0.04 ± 0.04, –0.19 ± 0.12, –0.59 ± 0.12 and –1.10 ± 0.05, respectively. The isomerization, in turn, shows dependence of rate on [H+][SH], [SH] and [S–], the βrg values (rg = remnant group) being –0.23 ± 0.04, –0.23 ± 0.11 and –0.03 ± 0.01. The mechanisms of various partial reactions are evaluated by comparing these values with those of specific and buffer catalyzed reactions of the corresponding 3′-phosphotriesters, regarded as mimetics of the neutral ionic form of diesters. Furthermore, the mechanistic significance of the dissimilar competition between the cleavage and isomerization with diesters and triesters is discussed." @default.
• W2116957788 created "2016-06-24" @default.
• W2116957788 creator A5022340846 @default.
• W2116957788 creator A5051602267 @default.
• W2116957788 creator A5056056886 @default.
• W2116957788 creator A5082049077 @default.
• W2116957788 date "1998-01-01" @default.
• W2116957788 modified "2023-10-01" @default.
• W2116957788 title "pH- and buffer-independent cleavage and mutual isomerization of uridine 2′- and 3′-alkyl phosphodiesters: implications for the buffer catalyzed cleavage of RNA" @default.
• W2116957788 cites W1982852504 @default.
• W2116957788 cites W1993616842 @default.
• W2116957788 cites W1996566831 @default.
• W2116957788 cites W2015293171 @default.
• W2116957788 cites W2031137724 @default.
• W2116957788 cites W2032285284 @default.
• W2116957788 cites W2058811224 @default.
• W2116957788 cites W2061296882 @default.
• W2116957788 cites W2061660519 @default.
• W2116957788 cites W2068512922 @default.
• W2116957788 cites W2070466213 @default.
• W2116957788 cites W2073925095 @default.
• W2116957788 cites W2088677737 @default.
• W2116957788 doi "https://doi.org/10.1039/a801670d" @default.
• W2116957788 hasPublicationYear "1998" @default.
• W2116957788 type Work @default.
• W2116957788 sameAs 2116957788 @default.
• W2116957788 citedByCount "22" @default.
• W2116957788 countsByYear W21169577882012 @default.
• W2116957788 countsByYear W21169577882013 @default.
• W2116957788 countsByYear W21169577882014 @default.
• W2116957788 countsByYear W21169577882015 @default.
• W2116957788 countsByYear W21169577882017 @default.
• W2116957788 countsByYear W21169577882018 @default.
• W2116957788 countsByYear W21169577882022 @default.
• W2116957788 crossrefType "journal-article" @default.
• W2116957788 hasAuthorship W2116957788A5022340846 @default.
• W2116957788 hasAuthorship W2116957788A5051602267 @default.
• W2116957788 hasAuthorship W2116957788A5056056886 @default.
• W2116957788 hasAuthorship W2116957788A5082049077 @default.
• W2116957788 hasConcept C104317684 @default.
• W2116957788 hasConcept C121332964 @default.
• W2116957788 hasConcept C126661725 @default.
• W2116957788 hasConcept C127413603 @default.
• W2116957788 hasConcept C148898269 @default.
• W2116957788 hasConcept C155647269 @default.
• W2116957788 hasConcept C161790260 @default.
• W2116957788 hasConcept C175156509 @default.
• W2116957788 hasConcept C178790620 @default.
• W2116957788 hasConcept C184651966 @default.
• W2116957788 hasConcept C185592680 @default.
• W2116957788 hasConcept C187320778 @default.
• W2116957788 hasConcept C187428577 @default.
• W2116957788 hasConcept C2777132085 @default.
• W2116957788 hasConcept C2780263894 @default.
• W2116957788 hasConcept C2781259782 @default.
• W2116957788 hasConcept C43369102 @default.
• W2116957788 hasConcept C43617362 @default.
• W2116957788 hasConcept C55493867 @default.
• W2116957788 hasConcept C62520636 @default.
• W2116957788 hasConcept C67705224 @default.
• W2116957788 hasConcept C71240020 @default.
• W2116957788 hasConcept C96616956 @default.
• W2116957788 hasConceptScore W2116957788C104317684 @default.
• W2116957788 hasConceptScore W2116957788C121332964 @default.
• W2116957788 hasConceptScore W2116957788C126661725 @default.
• W2116957788 hasConceptScore W2116957788C127413603 @default.
• W2116957788 hasConceptScore W2116957788C148898269 @default.
• W2116957788 hasConceptScore W2116957788C155647269 @default.
• W2116957788 hasConceptScore W2116957788C161790260 @default.
• W2116957788 hasConceptScore W2116957788C175156509 @default.
• W2116957788 hasConceptScore W2116957788C178790620 @default.
• W2116957788 hasConceptScore W2116957788C184651966 @default.
• W2116957788 hasConceptScore W2116957788C185592680 @default.
• W2116957788 hasConceptScore W2116957788C187320778 @default.
• W2116957788 hasConceptScore W2116957788C187428577 @default.
• W2116957788 hasConceptScore W2116957788C2777132085 @default.
• W2116957788 hasConceptScore W2116957788C2780263894 @default.
• W2116957788 hasConceptScore W2116957788C2781259782 @default.
• W2116957788 hasConceptScore W2116957788C43369102 @default.
• W2116957788 hasConceptScore W2116957788C43617362 @default.
• W2116957788 hasConceptScore W2116957788C55493867 @default.
• W2116957788 hasConceptScore W2116957788C62520636 @default.
• W2116957788 hasConceptScore W2116957788C67705224 @default.
• W2116957788 hasConceptScore W2116957788C71240020 @default.
• W2116957788 hasConceptScore W2116957788C96616956 @default.
• W2116957788 hasIssue "7" @default.
• W2116957788 hasLocation W21169577881 @default.
• W2116957788 hasOpenAccess W2116957788 @default.
• W2116957788 hasPrimaryLocation W21169577881 @default.
• W2116957788 hasRelatedWork W1981567806 @default.
• W2116957788 hasRelatedWork W2010856210 @default.
• W2116957788 hasRelatedWork W2116957788 @default.
• W2116957788 hasRelatedWork W2136103082 @default.
• W2116957788 hasRelatedWork W2324898221 @default.
• W2116957788 hasRelatedWork W2325933797 @default.
• W2116957788 hasRelatedWork W2388248681 @default.
• W2116957788 hasRelatedWork W2605206679 @default.
• W2116957788 hasRelatedWork W2952121703 @default.

• next