Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116965105> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2116965105 endingPage "99" @default.
- W2116965105 startingPage "94" @default.
- W2116965105 abstract "Studies investigating the testicular toxicity of 1,3-dinitrobenzene (1,3-DNB) have utilized both the oral (po) and intraperitoneal (ip) routes of administration. These two administration routes could be expected to produce different pharmacokinetic profiles and, potentially, different degrees of toxicity. In the present work, the effect of route of administration upon 1,3-DNB disposition and susceptibility to testicular damage has been investigated. Male Sprague-Dawley rats were given 25 mg/kg 1,3-DNB either ip or po. Metabolites were quantitated in blood, urine, and feces, and methemoglobin levels were determined. Peak blood levels of 1,3-DNB and its major metabolite were three times higher in ip-dosed rats than in po-dosed rats. While the lower blood levels seen after po administration were maintained for greater than 6 hr, blood levels fell rapidly after ip dosing, reaching po levels at 6 hr postadministration. Peak methemoglobin levels in ip-dosed animals were twice that of po-dosed animals. Route of administration had a minor effect on the levels of urinary metabolites, while there was a significantly higher excretion of metabolites in the feces of po-dosed animals. Despite the markedly higher 1,3-DNB blood levels after ip administration, there were only subtle differences in testicular damage. The data raise the possibility that above a threshold level of 1,3-DNB in the blood, only the duration of testicular exposure to the toxicant may govern susceptibility to testicular toxicity." @default.
- W2116965105 created "2016-06-24" @default.
- W2116965105 creator A5001845705 @default.
- W2116965105 creator A5048325113 @default.
- W2116965105 creator A5066183536 @default.
- W2116965105 creator A5069133314 @default.
- W2116965105 date "1995-11-01" @default.
- W2116965105 modified "2023-10-07" @default.
- W2116965105 title "Metabolism and Testicular Toxicity of 1,3-Dinitrobenzene in the Rat: Effect of Route of Administration" @default.
- W2116965105 doi "https://doi.org/10.1006/faat.1995.1150" @default.
- W2116965105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8566489" @default.
- W2116965105 hasPublicationYear "1995" @default.
- W2116965105 type Work @default.
- W2116965105 sameAs 2116965105 @default.
- W2116965105 citedByCount "11" @default.
- W2116965105 countsByYear W21169651052012 @default.
- W2116965105 countsByYear W21169651052014 @default.
- W2116965105 countsByYear W21169651052015 @default.
- W2116965105 countsByYear W21169651052023 @default.
- W2116965105 crossrefType "journal-article" @default.
- W2116965105 hasAuthorship W2116965105A5001845705 @default.
- W2116965105 hasAuthorship W2116965105A5048325113 @default.
- W2116965105 hasAuthorship W2116965105A5066183536 @default.
- W2116965105 hasAuthorship W2116965105A5069133314 @default.
- W2116965105 hasConcept C10146269 @default.
- W2116965105 hasConcept C112705442 @default.
- W2116965105 hasConcept C126322002 @default.
- W2116965105 hasConcept C134018914 @default.
- W2116965105 hasConcept C185592680 @default.
- W2116965105 hasConcept C195289149 @default.
- W2116965105 hasConcept C26865036 @default.
- W2116965105 hasConcept C2776093070 @default.
- W2116965105 hasConcept C2777477808 @default.
- W2116965105 hasConcept C2778917026 @default.
- W2116965105 hasConcept C2780026642 @default.
- W2116965105 hasConcept C2780473477 @default.
- W2116965105 hasConcept C29730261 @default.
- W2116965105 hasConcept C33070731 @default.
- W2116965105 hasConcept C71924100 @default.
- W2116965105 hasConcept C86803240 @default.
- W2116965105 hasConcept C98274493 @default.
- W2116965105 hasConceptScore W2116965105C10146269 @default.
- W2116965105 hasConceptScore W2116965105C112705442 @default.
- W2116965105 hasConceptScore W2116965105C126322002 @default.
- W2116965105 hasConceptScore W2116965105C134018914 @default.
- W2116965105 hasConceptScore W2116965105C185592680 @default.
- W2116965105 hasConceptScore W2116965105C195289149 @default.
- W2116965105 hasConceptScore W2116965105C26865036 @default.
- W2116965105 hasConceptScore W2116965105C2776093070 @default.
- W2116965105 hasConceptScore W2116965105C2777477808 @default.
- W2116965105 hasConceptScore W2116965105C2778917026 @default.
- W2116965105 hasConceptScore W2116965105C2780026642 @default.
- W2116965105 hasConceptScore W2116965105C2780473477 @default.
- W2116965105 hasConceptScore W2116965105C29730261 @default.
- W2116965105 hasConceptScore W2116965105C33070731 @default.
- W2116965105 hasConceptScore W2116965105C71924100 @default.
- W2116965105 hasConceptScore W2116965105C86803240 @default.
- W2116965105 hasConceptScore W2116965105C98274493 @default.
- W2116965105 hasIssue "1" @default.
- W2116965105 hasLocation W21169651051 @default.
- W2116965105 hasLocation W21169651052 @default.
- W2116965105 hasOpenAccess W2116965105 @default.
- W2116965105 hasPrimaryLocation W21169651051 @default.
- W2116965105 hasRelatedWork W1523811764 @default.
- W2116965105 hasRelatedWork W2034779505 @default.
- W2116965105 hasRelatedWork W2101972074 @default.
- W2116965105 hasRelatedWork W2494619688 @default.
- W2116965105 hasRelatedWork W2765349595 @default.
- W2116965105 hasRelatedWork W2994568380 @default.
- W2116965105 hasRelatedWork W4366068036 @default.
- W2116965105 hasRelatedWork W884233259 @default.
- W2116965105 hasRelatedWork W978626386 @default.
- W2116965105 hasRelatedWork W3150809875 @default.
- W2116965105 hasVolume "28" @default.
- W2116965105 isParatext "false" @default.
- W2116965105 isRetracted "false" @default.
- W2116965105 magId "2116965105" @default.
- W2116965105 workType "article" @default.