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- W2116974984 abstract "Abstract Radiotherapy, an important treatment modality in oncology, kills cells through induction of oxidative stress. However, malignant tumors vary in their response to irradiation as a consequence of resistance mechanisms taking place at the molecular level. It is important to understand these mechanisms of radioresistance, as counteracting them may improve the efficacy of radiotherapy. In this review, we describe how the hypoxia-inducible factor 1 (HIF-1) pathway has a profound effect on the response to radiotherapy. The main focus will be on HIF-1–controlled protection of the vasculature postirradiation and on HIF-1 regulation of glycolysis and the pentose phosphate pathway. This aberrant cellular metabolism increases the antioxidant capacity of tumors, thereby countering the oxidative stress caused by irradiation. From the results of translational studies and the first clinical phase I/II trials, it can be concluded that targeting HIF-1 and tumor glucose metabolism at several levels reduces the antioxidant capacity of tumors, affects the tumor microenvironment, and sensitizes various solid tumors to irradiation. Clin Cancer Res; 18(20); 5585–94. ©2012 AACR." @default.
- W2116974984 created "2016-06-24" @default.
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- W2116974984 date "2012-10-14" @default.
- W2116974984 modified "2023-10-14" @default.
- W2116974984 title "Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy" @default.
- W2116974984 cites W1964860185 @default.
- W2116974984 cites W1967736783 @default.
- W2116974984 cites W1968140809 @default.
- W2116974984 cites W1969591052 @default.
- W2116974984 cites W1971917580 @default.
- W2116974984 cites W1972779889 @default.
- W2116974984 cites W1980275866 @default.
- W2116974984 cites W1981849520 @default.
- W2116974984 cites W1992319933 @default.
- W2116974984 cites W1996507796 @default.
- W2116974984 cites W1997122877 @default.
- W2116974984 cites W1998279982 @default.
- W2116974984 cites W1998997961 @default.
- W2116974984 cites W2000001458 @default.
- W2116974984 cites W2002752049 @default.
- W2116974984 cites W2007255509 @default.
- W2116974984 cites W2007416032 @default.
- W2116974984 cites W2013080898 @default.
- W2116974984 cites W2015674248 @default.
- W2116974984 cites W2016861891 @default.
- W2116974984 cites W2018342523 @default.
- W2116974984 cites W2021117623 @default.
- W2116974984 cites W2030368798 @default.
- W2116974984 cites W2030575063 @default.
- W2116974984 cites W2031628684 @default.
- W2116974984 cites W2031681500 @default.
- W2116974984 cites W2032742826 @default.
- W2116974984 cites W2033556029 @default.
- W2116974984 cites W2034417993 @default.
- W2116974984 cites W2035983112 @default.
- W2116974984 cites W2037908392 @default.
- W2116974984 cites W2046687522 @default.
- W2116974984 cites W2052137498 @default.
- W2116974984 cites W2053662954 @default.
- W2116974984 cites W2055816439 @default.
- W2116974984 cites W2057366549 @default.
- W2116974984 cites W2058691572 @default.
- W2116974984 cites W2060628991 @default.
- W2116974984 cites W2060878129 @default.
- W2116974984 cites W2070692392 @default.
- W2116974984 cites W2074824347 @default.
- W2116974984 cites W2079265161 @default.
- W2116974984 cites W2081724546 @default.
- W2116974984 cites W2091068407 @default.
- W2116974984 cites W2091894720 @default.
- W2116974984 cites W2092464102 @default.
- W2116974984 cites W2095699480 @default.
- W2116974984 cites W2097259163 @default.
- W2116974984 cites W2099810479 @default.
- W2116974984 cites W2102416115 @default.
- W2116974984 cites W2110015442 @default.
- W2116974984 cites W2110411886 @default.
- W2116974984 cites W2110492979 @default.
- W2116974984 cites W2112143589 @default.
- W2116974984 cites W2115538252 @default.
- W2116974984 cites W2117692326 @default.
- W2116974984 cites W2119216120 @default.
- W2116974984 cites W2123838717 @default.
- W2116974984 cites W2125257427 @default.
- W2116974984 cites W2127096730 @default.
- W2116974984 cites W2129191085 @default.
- W2116974984 cites W2129789838 @default.
- W2116974984 cites W2132201273 @default.
- W2116974984 cites W2133845068 @default.
- W2116974984 cites W2135747672 @default.
- W2116974984 cites W2136348963 @default.
- W2116974984 cites W2146228341 @default.
- W2116974984 cites W2146270900 @default.
- W2116974984 cites W2149786785 @default.
- W2116974984 cites W2151196497 @default.
- W2116974984 cites W2152237718 @default.
- W2116974984 cites W2153328392 @default.
- W2116974984 cites W2156824694 @default.
- W2116974984 cites W2159194061 @default.
- W2116974984 cites W2159328080 @default.
- W2116974984 cites W2160351951 @default.
- W2116974984 cites W2162868196 @default.
- W2116974984 cites W2165241843 @default.
- W2116974984 cites W2166574330 @default.
- W2116974984 cites W2168009999 @default.
- W2116974984 cites W2168353595 @default.
- W2116974984 cites W2914002569 @default.
- W2116974984 cites W385154357 @default.
- W2116974984 doi "https://doi.org/10.1158/1078-0432.ccr-12-0858" @default.
- W2116974984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23071360" @default.
- W2116974984 hasPublicationYear "2012" @default.
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