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• W2116985478 abstract "Leukotrienes are inflammatory and vasoactive mediators implicated in endothelium-dependent relaxations and atherosclerosis. Urinary leukotriene E 4 (U-LTE 4 ) is a validated disease marker of asthma and increases also in diabetes and acute coronary syndromes. The aim of the present study was to evaluate the association of U-LTE 4 and CRP with endothelial function. Urine samples were obtained from 30 subjects (80% males; median age 65) with type 2 diabetes of at least two years duration and a median glomerular filtration rate (eGFR) of 71 (14–129) mL/min. Reactive hyperemia index (RHI) was used as a measure of microvascular endothelial function, whereas macrovascular endothelial function was determined be means of flow-mediated dilatation of the brachial artery (FMD). Decreased renal function was associated with lower concentrations of U-LTE 4 . In addition, U-LTE 4 was correlated with serum creatinine (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.572</mml:mn></mml:mrow></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>) and eGFR (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mn>0.517</mml:mn></mml:mrow></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0036</mml:mn></mml:mrow></mml:math>). A stepwise multiple linear regression analysis identified eGFR as an independent predictor of U-LTE 4 concentrations. In conclusion, the present results did not establish an association of U-LTE 4 with endothelial dysfunction. However, eGFR was an independent predictor of U-LTE 4 , but not CRP, in this cohort, suggesting that GFR should be considered in biomarker studies of U-LTE 4 ." @default.
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• W2116985478 date "2013-01-01" @default.
• W2116985478 modified "2023-10-17" @default.
• W2116985478 title "Urinary Leukotriene E₄Is Associated with Renal Function but Not with Endothelial Function in Type 2 Diabetes" @default.
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• W2116985478 doi "https://doi.org/10.1155/2013/370461" @default.
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