FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116988190> ?p ?o ?g. }

• W2116988190 endingPage "858" @default.
• W2116988190 startingPage "850" @default.
• W2116988190 abstract "<i>Salvia miltiorrhiza</i> (Danshen), a traditional Chinese herbal medicine, is commonly used for the prevention and treatment of cardiovascular disorders including atherosclerosis. However, the mechanisms responsible for the vasoprotective effects of Danshen remain largely unknown. Salvianolic acid B (Sal B) represents one of the most bioactive compounds that can be extracted from the water-soluble fraction of Danshen. We investigated the effects of Danshen and Sal B on the inflammatory response in murine macrophages. Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Inhibition of HO activity using Sn-protoporphyrin-IX (SnPP) abolished the inhibitory effect of Sal B on NO production and iNOS expression. Sal B increased macrophage arginase activity in a dose-dependent manner and diminished LPS-inducible tumor necrosis factor-α production. These effects were also reversed by SnPP. These data suggest that HO-1 expression plays an intermediary role in the anti-inflammatory effects of Sal B. In contrast to the observations in macrophages, Sal B dose-dependently inhibited arginase activity in murine liver, kidney, and vascular tissue. Furthermore, Sal B increased NO production in isolated mouse aortas through the inhibition of arginase activity and reduction of reactive oxygen species production. We conclude that Sal B improves vascular function by inhibiting inflammatory responses and promoting endothelium-dependent vasodilation. Taken together, we suggest that Sal B may represent a potent candidate therapeutic for the treatment of cardiovascular diseases associated with endothelial dysfunction." @default.
• W2116988190 created "2016-06-24" @default.
• W2116988190 creator A5006057664 @default.
• W2116988190 creator A5011007277 @default.
• W2116988190 creator A5011798225 @default.
• W2116988190 creator A5046129212 @default.
• W2116988190 creator A5048566776 @default.
• W2116988190 creator A5052135528 @default.
• W2116988190 creator A5059805057 @default.
• W2116988190 creator A5060136564 @default.
• W2116988190 creator A5068367251 @default.
• W2116988190 creator A5072972493 @default.
• W2116988190 creator A5075200035 @default.
• W2116988190 creator A5081161757 @default.
• W2116988190 date "2012-03-22" @default.
• W2116988190 modified "2023-10-07" @default.
• W2116988190 title "Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities" @default.
• W2116988190 cites W1509979785 @default.
• W2116988190 cites W1519147845 @default.
• W2116988190 cites W1587377302 @default.
• W2116988190 cites W1600690434 @default.
• W2116988190 cites W1678800844 @default.
• W2116988190 cites W1868478050 @default.
• W2116988190 cites W1966856205 @default.
• W2116988190 cites W1976944744 @default.
• W2116988190 cites W1984448396 @default.
• W2116988190 cites W1984997174 @default.
• W2116988190 cites W1989807669 @default.
• W2116988190 cites W1993503607 @default.
• W2116988190 cites W1996866382 @default.
• W2116988190 cites W2001461795 @default.
• W2116988190 cites W2003646765 @default.
• W2116988190 cites W2014797738 @default.
• W2116988190 cites W2016687652 @default.
• W2116988190 cites W2023170094 @default.
• W2116988190 cites W2032207767 @default.
• W2116988190 cites W2035264886 @default.
• W2116988190 cites W2038229511 @default.
• W2116988190 cites W2044918962 @default.
• W2116988190 cites W2057092234 @default.
• W2116988190 cites W2063680573 @default.
• W2116988190 cites W2064951063 @default.
• W2116988190 cites W2073825819 @default.
• W2116988190 cites W2103031745 @default.
• W2116988190 cites W2105821269 @default.
• W2116988190 cites W2106101066 @default.
• W2116988190 cites W2120046557 @default.
• W2116988190 cites W2120628764 @default.
• W2116988190 cites W2122538212 @default.
• W2116988190 cites W2145306215 @default.
• W2116988190 cites W2149478838 @default.
• W2116988190 cites W2154066769 @default.
• W2116988190 cites W2162926356 @default.
• W2116988190 cites W2168276787 @default.
• W2116988190 cites W2179702494 @default.
• W2116988190 doi "https://doi.org/10.1124/jpet.111.190736" @default.
• W2116988190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22442118" @default.
• W2116988190 hasPublicationYear "2012" @default.
• W2116988190 type Work @default.
• W2116988190 sameAs 2116988190 @default.
• W2116988190 citedByCount "67" @default.
• W2116988190 countsByYear W21169881902012 @default.
• W2116988190 countsByYear W21169881902013 @default.
• W2116988190 countsByYear W21169881902014 @default.
• W2116988190 countsByYear W21169881902015 @default.
• W2116988190 countsByYear W21169881902016 @default.
• W2116988190 countsByYear W21169881902017 @default.
• W2116988190 countsByYear W21169881902018 @default.
• W2116988190 countsByYear W21169881902019 @default.
• W2116988190 countsByYear W21169881902020 @default.
• W2116988190 countsByYear W21169881902021 @default.
• W2116988190 countsByYear W21169881902022 @default.
• W2116988190 countsByYear W21169881902023 @default.
• W2116988190 crossrefType "journal-article" @default.
• W2116988190 hasAuthorship W2116988190A5006057664 @default.
• W2116988190 hasAuthorship W2116988190A5011007277 @default.
• W2116988190 hasAuthorship W2116988190A5011798225 @default.
• W2116988190 hasAuthorship W2116988190A5046129212 @default.
• W2116988190 hasAuthorship W2116988190A5048566776 @default.
• W2116988190 hasAuthorship W2116988190A5052135528 @default.
• W2116988190 hasAuthorship W2116988190A5059805057 @default.
• W2116988190 hasAuthorship W2116988190A5060136564 @default.
• W2116988190 hasAuthorship W2116988190A5068367251 @default.
• W2116988190 hasAuthorship W2116988190A5072972493 @default.
• W2116988190 hasAuthorship W2116988190A5075200035 @default.
• W2116988190 hasAuthorship W2116988190A5081161757 @default.
• W2116988190 hasConcept C142724271 @default.
• W2116988190 hasConcept C164007495 @default.
• W2116988190 hasConcept C178790620 @default.
• W2116988190 hasConcept C17991360 @default.
• W2116988190 hasConcept C181199279 @default.
• W2116988190 hasConcept C185592680 @default.
• W2116988190 hasConcept C188947578 @default.
• W2116988190 hasConcept C203014093 @default.
• W2116988190 hasConcept C204787440 @default.
• W2116988190 hasConcept C2776217839 @default.
• W2116988190 hasConcept C2776332195 @default.
• W2116988190 hasConcept C2777468819 @default.

• next