Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116992727> ?p ?o ?g. }
- W2116992727 endingPage "29" @default.
- W2116992727 startingPage "15" @default.
- W2116992727 abstract "The role of Wnt signalling in carcinogenesis suggests compounds targeting this pathway as potential anti-cancer drugs. Several studies report activation of Wnt signalling in biliary tract cancer (BTC) thus rendering Wnt inhibitory drugs as potential candidates for targeted therapy of this highly chemoresistant disease.In this study we analysed five compounds with suggested inhibitory effects on Wnt signalling (DMAT, FH535, myricetin, quercetin, and TBB) for their cytotoxic efficiency, mode of cell death, time- and cell line-dependent characteristics as well as their effects on Wnt pathway activity in nine different BTC cell lines.Exposure of cancer cells to different concentrations of the compounds results in a clear dose-dependent reduction of viability for all drugs in the order FH535 > DMAT > TBB > myricetin > quercetin. The first three substances show high cytotoxicity in all tested cell lines, cause a direct cytotoxic effect by induction of apoptosis and inhibit pathway-specific signal transduction in a Wnt transcription factor reporter activity assay. Selected target genes such as growth-promoting cyclin D1 and the cell cycle progression inhibitor p27 are down- and up-regulated after treatment, respectively.Taken together, these data demonstrate that the small molecular weight inhibitors DMAT, F535 and TBB have a considerable cytotoxic and possibly Wnt-specific effect on BTC cell lines in vitro. Further in vivo investigation of these drugs as well as of new Wnt inhibitors may provide a promising approach for targeted therapy of this difficult-to-treat tumour." @default.
- W2116992727 created "2016-06-24" @default.
- W2116992727 creator A5006483196 @default.
- W2116992727 creator A5010743128 @default.
- W2116992727 creator A5017416078 @default.
- W2116992727 creator A5017627764 @default.
- W2116992727 creator A5018588889 @default.
- W2116992727 creator A5023411290 @default.
- W2116992727 creator A5023869828 @default.
- W2116992727 creator A5025665934 @default.
- W2116992727 creator A5051003744 @default.
- W2116992727 creator A5072336215 @default.
- W2116992727 date "2012-01-01" @default.
- W2116992727 modified "2023-10-01" @default.
- W2116992727 title "Influence of Five Potential Anticancer Drugs on Wnt Pathway and Cell Survival in Human Biliary Tract Cancer Cells" @default.
- W2116992727 cites W1836452880 @default.
- W2116992727 cites W1964491978 @default.
- W2116992727 cites W1964492562 @default.
- W2116992727 cites W1964825240 @default.
- W2116992727 cites W1971134531 @default.
- W2116992727 cites W1973139255 @default.
- W2116992727 cites W1975853332 @default.
- W2116992727 cites W1976359234 @default.
- W2116992727 cites W1983712244 @default.
- W2116992727 cites W1984908936 @default.
- W2116992727 cites W1987595432 @default.
- W2116992727 cites W1990671646 @default.
- W2116992727 cites W1991598182 @default.
- W2116992727 cites W1992351733 @default.
- W2116992727 cites W2001566685 @default.
- W2116992727 cites W2020444289 @default.
- W2116992727 cites W2022369010 @default.
- W2116992727 cites W2024215200 @default.
- W2116992727 cites W2030606608 @default.
- W2116992727 cites W2042410625 @default.
- W2116992727 cites W2044558525 @default.
- W2116992727 cites W2045874559 @default.
- W2116992727 cites W2049920899 @default.
- W2116992727 cites W2054307087 @default.
- W2116992727 cites W2055800929 @default.
- W2116992727 cites W2066696585 @default.
- W2116992727 cites W2070199262 @default.
- W2116992727 cites W2070244957 @default.
- W2116992727 cites W2072619337 @default.
- W2116992727 cites W2074616967 @default.
- W2116992727 cites W2086152184 @default.
- W2116992727 cites W2088938650 @default.
- W2116992727 cites W2091297863 @default.
- W2116992727 cites W2100528101 @default.
- W2116992727 cites W2109069210 @default.
- W2116992727 cites W2111251544 @default.
- W2116992727 cites W2111566722 @default.
- W2116992727 cites W2114985954 @default.
- W2116992727 cites W2115261608 @default.
- W2116992727 cites W2119780609 @default.
- W2116992727 cites W2120269934 @default.
- W2116992727 cites W2121820789 @default.
- W2116992727 cites W2139445161 @default.
- W2116992727 cites W2139644179 @default.
- W2116992727 cites W2140374331 @default.
- W2116992727 cites W2149568076 @default.
- W2116992727 cites W2170558356 @default.
- W2116992727 cites W80868934 @default.
- W2116992727 doi "https://doi.org/10.7150/ijbs.8.15" @default.
- W2116992727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3226029" @default.
- W2116992727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22211101" @default.
- W2116992727 hasPublicationYear "2012" @default.
- W2116992727 type Work @default.
- W2116992727 sameAs 2116992727 @default.
- W2116992727 citedByCount "26" @default.
- W2116992727 countsByYear W21169927272012 @default.
- W2116992727 countsByYear W21169927272013 @default.
- W2116992727 countsByYear W21169927272014 @default.
- W2116992727 countsByYear W21169927272015 @default.
- W2116992727 countsByYear W21169927272016 @default.
- W2116992727 countsByYear W21169927272017 @default.
- W2116992727 countsByYear W21169927272018 @default.
- W2116992727 countsByYear W21169927272019 @default.
- W2116992727 countsByYear W21169927272021 @default.
- W2116992727 countsByYear W21169927272022 @default.
- W2116992727 crossrefType "journal-article" @default.
- W2116992727 hasAuthorship W2116992727A5006483196 @default.
- W2116992727 hasAuthorship W2116992727A5010743128 @default.
- W2116992727 hasAuthorship W2116992727A5017416078 @default.
- W2116992727 hasAuthorship W2116992727A5017627764 @default.
- W2116992727 hasAuthorship W2116992727A5018588889 @default.
- W2116992727 hasAuthorship W2116992727A5023411290 @default.
- W2116992727 hasAuthorship W2116992727A5023869828 @default.
- W2116992727 hasAuthorship W2116992727A5025665934 @default.
- W2116992727 hasAuthorship W2116992727A5051003744 @default.
- W2116992727 hasAuthorship W2116992727A5072336215 @default.
- W2116992727 hasBestOaLocation W21169927271 @default.
- W2116992727 hasConcept C121608353 @default.
- W2116992727 hasConcept C137620995 @default.
- W2116992727 hasConcept C154317977 @default.
- W2116992727 hasConcept C185592680 @default.
- W2116992727 hasConcept C190283241 @default.
- W2116992727 hasConcept C199835354 @default.