FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116993485> ?p ?o ?g. }

• W2116993485 endingPage "e22392" @default.
• W2116993485 startingPage "e22392" @default.
• W2116993485 abstract "Naturally occurring DNA sequence variation within a species underlies evolutionary adaptation and can give rise to phenotypic changes that provide novel insight into biological questions. This variation exists in laboratory populations just as in wild populations and, in addition to being a source of useful alleles for genetic studies, can impact efforts to identify induced mutations in sequence-based genetic screens. The Western clawed frog Xenopus tropicalis (X. tropicalis) has been adopted as a model system for studying the genetic control of embryonic development and a variety of other areas of research. Its diploid genome has been extensively sequenced and efforts are underway to isolate mutants by phenotype- and genotype-based approaches. Here, we describe a study of genetic polymorphism in laboratory strains of X. tropicalis. Polymorphism was detected in the coding and non-coding regions of developmental genes distributed widely across the genome. Laboratory strains exhibit unexpectedly high frequencies of genetic polymorphism, with alleles carrying a variety of synonymous and non-synonymous codon substitutions and nucleotide insertions/deletions. Inter-strain comparisons of polymorphism uncover a high proportion of shared alleles between Nigerian and Ivory Coast strains, in spite of their distinct geographical origins. These observations will likely influence the design of future sequence-based mutation screens, particularly those using DNA mismatch-based detection methods which can be disrupted by the presence of naturally occurring sequence variants. The existence of a significant reservoir of alleles also suggests that existing laboratory stocks may be a useful source of novel alleles for mapping and functional studies." @default.
• W2116993485 created "2016-06-24" @default.
• W2116993485 creator A5001468756 @default.
• W2116993485 creator A5006697286 @default.
• W2116993485 creator A5019341134 @default.
• W2116993485 creator A5065261252 @default.
• W2116993485 creator A5065512493 @default.
• W2116993485 creator A5068334615 @default.
• W2116993485 date "2011-08-04" @default.
• W2116993485 modified "2023-10-18" @default.
• W2116993485 title "A Comparative Survey of the Frequency and Distribution of Polymorphism in the Genome of Xenopus tropicalis" @default.
• W2116993485 cites W1875729531 @default.
• W2116993485 cites W1922272507 @default.
• W2116993485 cites W1972906909 @default.
• W2116993485 cites W1981366355 @default.
• W2116993485 cites W1981981738 @default.
• W2116993485 cites W1984046516 @default.
• W2116993485 cites W1996433825 @default.
• W2116993485 cites W1998083091 @default.
• W2116993485 cites W1999674359 @default.
• W2116993485 cites W2004517252 @default.
• W2116993485 cites W2009766419 @default.
• W2116993485 cites W2019249381 @default.
• W2116993485 cites W2032415634 @default.
• W2116993485 cites W2048585261 @default.
• W2116993485 cites W2052915489 @default.
• W2116993485 cites W2061008984 @default.
• W2116993485 cites W2063915954 @default.
• W2116993485 cites W2071139274 @default.
• W2116993485 cites W2090876688 @default.
• W2116993485 cites W2099343414 @default.
• W2116993485 cites W2103054437 @default.
• W2116993485 cites W2115591173 @default.
• W2116993485 cites W2131071295 @default.
• W2116993485 cites W2171114940 @default.
• W2116993485 cites W2171963306 @default.
• W2116993485 cites W4245228073 @default.
• W2116993485 cites W4254753097 @default.
• W2116993485 doi "https://doi.org/10.1371/journal.pone.0022392" @default.
• W2116993485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150332" @default.
• W2116993485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21829622" @default.
• W2116993485 hasPublicationYear "2011" @default.
• W2116993485 type Work @default.
• W2116993485 sameAs 2116993485 @default.
• W2116993485 citedByCount "6" @default.
• W2116993485 countsByYear W21169934852012 @default.
• W2116993485 countsByYear W21169934852014 @default.
• W2116993485 countsByYear W21169934852015 @default.
• W2116993485 countsByYear W21169934852017 @default.
• W2116993485 crossrefType "journal-article" @default.
• W2116993485 hasAuthorship W2116993485A5001468756 @default.
• W2116993485 hasAuthorship W2116993485A5006697286 @default.
• W2116993485 hasAuthorship W2116993485A5019341134 @default.
• W2116993485 hasAuthorship W2116993485A5065261252 @default.
• W2116993485 hasAuthorship W2116993485A5065512493 @default.
• W2116993485 hasAuthorship W2116993485A5068334615 @default.
• W2116993485 hasBestOaLocation W21169934851 @default.
• W2116993485 hasConcept C104317684 @default.
• W2116993485 hasConcept C135763542 @default.
• W2116993485 hasConcept C137848329 @default.
• W2116993485 hasConcept C141231307 @default.
• W2116993485 hasConcept C180754005 @default.
• W2116993485 hasConcept C24432333 @default.
• W2116993485 hasConcept C51679486 @default.
• W2116993485 hasConcept C54355233 @default.
• W2116993485 hasConcept C68873052 @default.
• W2116993485 hasConcept C86803240 @default.
• W2116993485 hasConcept C91779695 @default.
• W2116993485 hasConceptScore W2116993485C104317684 @default.
• W2116993485 hasConceptScore W2116993485C135763542 @default.
• W2116993485 hasConceptScore W2116993485C137848329 @default.
• W2116993485 hasConceptScore W2116993485C141231307 @default.
• W2116993485 hasConceptScore W2116993485C180754005 @default.
• W2116993485 hasConceptScore W2116993485C24432333 @default.
• W2116993485 hasConceptScore W2116993485C51679486 @default.
• W2116993485 hasConceptScore W2116993485C54355233 @default.
• W2116993485 hasConceptScore W2116993485C68873052 @default.
• W2116993485 hasConceptScore W2116993485C86803240 @default.
• W2116993485 hasConceptScore W2116993485C91779695 @default.
• W2116993485 hasIssue "8" @default.
• W2116993485 hasLocation W21169934851 @default.
• W2116993485 hasLocation W21169934852 @default.
• W2116993485 hasLocation W21169934853 @default.
• W2116993485 hasLocation W21169934854 @default.
• W2116993485 hasLocation W21169934855 @default.
• W2116993485 hasLocation W21169934856 @default.
• W2116993485 hasOpenAccess W2116993485 @default.
• W2116993485 hasPrimaryLocation W21169934851 @default.
• W2116993485 hasRelatedWork W1867987620 @default.
• W2116993485 hasRelatedWork W1988517967 @default.
• W2116993485 hasRelatedWork W2057739827 @default.
• W2116993485 hasRelatedWork W2070922469 @default.
• W2116993485 hasRelatedWork W2082651103 @default.
• W2116993485 hasRelatedWork W2170293083 @default.
• W2116993485 hasRelatedWork W2223919059 @default.
• W2116993485 hasRelatedWork W2883538728 @default.
• W2116993485 hasRelatedWork W3206047998 @default.
• W2116993485 hasRelatedWork W4238882508 @default.

• next