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• W2117000242 abstract "Flaky tail mice (FTM; ma/ma, Flgft/ft) have two pathogenic genetic abnormalities related to cutaneous permeability barrier homeostasis, namely, gene mutations in filaggrin (Flgft) and matted (ma), and are known to exhibit atopic dermatitis (AD)-like dermatitis “spontaneously” and the spontaneous emergence is mainly attributed to the matted mutation [ 1 Oyoshi M.K. Murphy G.F. Geha R.S. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009; 124 (93e1): 485-493 Abstract Full Text Full Text PDF PubMed Scopus (195) Google Scholar , 2 Moniaga C.S. Egawa G. Kawasaki H. Hara-Chikuma M. Honda T. Tanizaki H. et al. Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with dermatophagoides pteronyssinus extract. Am J Pathol. 2010; 176: 2385-2393 Abstract Full Text Full Text PDF PubMed Scopus (98) Google Scholar , 3 Saunders S.P. Goh C.S. Brown S.J. Palmer C.N. Porter R.M. Cole C. et al. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol. 2013; 132: 1121-1129 Abstract Full Text Full Text PDF PubMed Scopus (111) Google Scholar , 4 Sasaki T. Shiohama A. Kubo A. Kawasaki H. Ishida-Yamamoto A. Yamada T. et al. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol. 2013; 132: 1111-1120.e4 Abstract Full Text Full Text PDF PubMed Scopus (89) Google Scholar ]. Although FTM has been used as one of the murine AD models, whether such spontaneous emergence is consistent with the pathogenesis of human AD, in which genetic abnormalities are not the sole determinant but the combination of genetic abnormalities and environmental factors is the most important characteristic, remains questionable. In the present study, we determined whether site-dependent emergence of skin manifestations, which is one of clinical characteristics of human AD, is seen in FTM." @default.
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• W2117000242 date "2015-05-01" @default.
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• W2117000242 title "Atopic dermatitis-like dermatitis emerges unevenly on different sites in flaky tail mice" @default.
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• W2117000242 doi "https://doi.org/10.1016/j.jdermsci.2015.01.008" @default.
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