Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117029190> ?p ?o ?g. }
- W2117029190 endingPage "1463" @default.
- W2117029190 startingPage "1451" @default.
- W2117029190 abstract "Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites. Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior. Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders." @default.
- W2117029190 created "2016-06-24" @default.
- W2117029190 creator A5001992881 @default.
- W2117029190 creator A5003624509 @default.
- W2117029190 creator A5015135158 @default.
- W2117029190 creator A5016883027 @default.
- W2117029190 creator A5026573989 @default.
- W2117029190 creator A5031586366 @default.
- W2117029190 creator A5038661637 @default.
- W2117029190 creator A5053569958 @default.
- W2117029190 creator A5065251044 @default.
- W2117029190 creator A5081784508 @default.
- W2117029190 creator A5089637180 @default.
- W2117029190 creator A5090977841 @default.
- W2117029190 date "2013-12-01" @default.
- W2117029190 modified "2023-10-17" @default.
- W2117029190 title "Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders" @default.
- W2117029190 cites W1481250329 @default.
- W2117029190 cites W1811186957 @default.
- W2117029190 cites W1832427420 @default.
- W2117029190 cites W1884507993 @default.
- W2117029190 cites W1965651011 @default.
- W2117029190 cites W1966445705 @default.
- W2117029190 cites W1967482627 @default.
- W2117029190 cites W1968659204 @default.
- W2117029190 cites W1969615942 @default.
- W2117029190 cites W1978222253 @default.
- W2117029190 cites W1981500982 @default.
- W2117029190 cites W1995393174 @default.
- W2117029190 cites W1996441448 @default.
- W2117029190 cites W1998542183 @default.
- W2117029190 cites W2002038036 @default.
- W2117029190 cites W2002852362 @default.
- W2117029190 cites W2004429380 @default.
- W2117029190 cites W2004961725 @default.
- W2117029190 cites W2005365566 @default.
- W2117029190 cites W2010055058 @default.
- W2117029190 cites W2012266823 @default.
- W2117029190 cites W2012490955 @default.
- W2117029190 cites W2014008662 @default.
- W2117029190 cites W2016586816 @default.
- W2117029190 cites W2024392981 @default.
- W2117029190 cites W2030500910 @default.
- W2117029190 cites W2033995711 @default.
- W2117029190 cites W2034285706 @default.
- W2117029190 cites W2034421798 @default.
- W2117029190 cites W2034696724 @default.
- W2117029190 cites W2040039050 @default.
- W2117029190 cites W2046831320 @default.
- W2117029190 cites W2047677813 @default.
- W2117029190 cites W2048843644 @default.
- W2117029190 cites W2053588982 @default.
- W2117029190 cites W2053883300 @default.
- W2117029190 cites W2055043387 @default.
- W2117029190 cites W2060785552 @default.
- W2117029190 cites W2062496408 @default.
- W2117029190 cites W2064855192 @default.
- W2117029190 cites W2066011810 @default.
- W2117029190 cites W2069751221 @default.
- W2117029190 cites W2072970694 @default.
- W2117029190 cites W2075918530 @default.
- W2117029190 cites W2076260247 @default.
- W2117029190 cites W2080528636 @default.
- W2117029190 cites W2081161499 @default.
- W2117029190 cites W2082915634 @default.
- W2117029190 cites W2083579420 @default.
- W2117029190 cites W2098277878 @default.
- W2117029190 cites W2098616183 @default.
- W2117029190 cites W2099756187 @default.
- W2117029190 cites W2099856240 @default.
- W2117029190 cites W2104318549 @default.
- W2117029190 cites W2105329815 @default.
- W2117029190 cites W2106829739 @default.
- W2117029190 cites W2114392707 @default.
- W2117029190 cites W2117420804 @default.
- W2117029190 cites W2118649010 @default.
- W2117029190 cites W2119799034 @default.
- W2117029190 cites W2120701088 @default.
- W2117029190 cites W2124351063 @default.
- W2117029190 cites W2125531274 @default.
- W2117029190 cites W2126570610 @default.
- W2117029190 cites W2127366570 @default.
- W2117029190 cites W2129548794 @default.
- W2117029190 cites W2132438753 @default.
- W2117029190 cites W2133856765 @default.
- W2117029190 cites W2135025386 @default.
- W2117029190 cites W2136879569 @default.
- W2117029190 cites W2140268100 @default.
- W2117029190 cites W2145189896 @default.
- W2117029190 cites W2148546434 @default.
- W2117029190 cites W2148945503 @default.
- W2117029190 cites W2149421543 @default.
- W2117029190 cites W2149756110 @default.
- W2117029190 cites W2150968312 @default.
- W2117029190 cites W2151259830 @default.
- W2117029190 cites W2153562609 @default.
- W2117029190 cites W2154965665 @default.
- W2117029190 cites W2155806125 @default.