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- W2117029218 abstract "Research on the interface self-assembly of functional layers is fuelled by diverse biomedical needs, like drug encapsulation and release, stem cell proliferation and differentiation, cell and tissue cultures, as well as artificial organs. In this study, a novel and biocompatible 3D composite layer is fabricated on a membrane substrate by the layer-by-layer (LBL) self-assembly of graphene-based 2D supermolecules. The graphene-based 2D supermolecules are prepared by grafting poly(styrenesulfonate) (PSS, polyanion) and poly(acrylamide) (PAM, polycation) onto graphene oxide (GO) through free radical polymerization. Then, the prepared graphene-based supermolecules are taken to construct a 3D porous thin film layer through a LBL process. Polyethersulfone (PES) membrane is chosen as the model substrate. The chemical composition, surface morphology, water contact angle, surface zeta-potential, blood compatibility and the cell compatibility are systematically investigated. The results indicate that the 2D graphene-based supermolecules are successfully assembled into a 3D porous thin film layer structure on the membrane surface. The assembled layer shows increased hydrophilicity, suppressed platelet adhesion, and a limited hemolysis ratio and complement activation compared to the pristine substrate. The cell morphology observation and cytotoxicity assays demonstrate that the 3D graphene layer shows superior performance both in endothelial and hepatocyte cells proliferation and morphology differentiation. In addition, the excellent anticoagulant bioactivities indicate that the 2D graphene-based supermolecules have heparin-mimicking biological activity. In general, the protocol of interface thin film layer self-assembly confers the modified substrates with integrated blood compatibility, cell proliferation and biological activity; which may forward the fabrication of multi-functional biomedical devices by using the 2D graphene-based supermolecules." @default.
- W2117029218 created "2016-06-24" @default.
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- W2117029218 date "2014-01-01" @default.
- W2117029218 modified "2023-09-27" @default.
- W2117029218 title "Self-assembled 3D biocompatible and bioactive layer at the macro-interface via graphene-based supermolecules" @default.
- W2117029218 cites W1965189926 @default.
- W2117029218 cites W1966062300 @default.
- W2117029218 cites W1971934429 @default.
- W2117029218 cites W1975750858 @default.
- W2117029218 cites W1976424331 @default.
- W2117029218 cites W1978912097 @default.
- W2117029218 cites W1980881778 @default.
- W2117029218 cites W1984430446 @default.
- W2117029218 cites W1985094436 @default.
- W2117029218 cites W1993449110 @default.
- W2117029218 cites W1993893772 @default.
- W2117029218 cites W1997450801 @default.
- W2117029218 cites W2000884471 @default.
- W2117029218 cites W2004786617 @default.
- W2117029218 cites W2007903017 @default.
- W2117029218 cites W2013328140 @default.
- W2117029218 cites W2014276559 @default.
- W2117029218 cites W2015149841 @default.
- W2117029218 cites W2018253250 @default.
- W2117029218 cites W2019608827 @default.
- W2117029218 cites W2021484192 @default.
- W2117029218 cites W2031572528 @default.
- W2117029218 cites W2033154523 @default.
- W2117029218 cites W2036768186 @default.
- W2117029218 cites W2038859066 @default.
- W2117029218 cites W2040760633 @default.
- W2117029218 cites W2041309288 @default.
- W2117029218 cites W2043865568 @default.
- W2117029218 cites W2044066625 @default.
- W2117029218 cites W2048056641 @default.
- W2117029218 cites W2049256514 @default.
- W2117029218 cites W2051394400 @default.
- W2117029218 cites W2057593295 @default.
- W2117029218 cites W2058822018 @default.
- W2117029218 cites W2068511165 @default.
- W2117029218 cites W2071768545 @default.
- W2117029218 cites W2073629171 @default.
- W2117029218 cites W2076013936 @default.
- W2117029218 cites W2076164766 @default.
- W2117029218 cites W2076415862 @default.
- W2117029218 cites W2078022170 @default.
- W2117029218 cites W2081705834 @default.
- W2117029218 cites W2083140292 @default.
- W2117029218 cites W2083538534 @default.
- W2117029218 cites W2084538675 @default.
- W2117029218 cites W2085231228 @default.
- W2117029218 cites W2086970036 @default.
- W2117029218 cites W2088312435 @default.
- W2117029218 cites W2088727182 @default.
- W2117029218 cites W2090030249 @default.
- W2117029218 cites W2093524551 @default.
- W2117029218 cites W2114411218 @default.
- W2117029218 cites W2116325452 @default.
- W2117029218 cites W2133624634 @default.
- W2117029218 cites W2136193523 @default.
- W2117029218 cites W2138098255 @default.
- W2117029218 cites W2140805805 @default.
- W2117029218 cites W2152718092 @default.
- W2117029218 cites W2158570638 @default.
- W2117029218 cites W2158881351 @default.
- W2117029218 cites W2164586886 @default.
- W2117029218 cites W2165145490 @default.
- W2117029218 cites W2165680121 @default.
- W2117029218 cites W2168751929 @default.
- W2117029218 cites W2171905019 @default.
- W2117029218 cites W2324413634 @default.
- W2117029218 cites W2325097966 @default.
- W2117029218 cites W2334435507 @default.
- W2117029218 cites W4250532938 @default.
- W2117029218 doi "https://doi.org/10.1039/c4py00136b" @default.
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