Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117042893> ?p ?o ?g. }
- W2117042893 endingPage "5" @default.
- W2117042893 startingPage "241" @default.
- W2117042893 abstract "Relatively few cases of Epstein-Barr (EBV)-positive B-cell lymphomas arising in patients with angioimmunoblastic T-cell lymphoma (AITL) have been reported. We report a case of AITL in which diffuse large B-cell lymphoma arose 13 months after the initial diagnosis of AITL. In a 36-year-old female patient, evaluated for moderate leukocytosis, peripheral and abdominal lymphadenopathy AITL was diagnosed in March 2008, based on results of fine-needle aspiration cytology (FNAC) of the enlarged cervical and supraclavicular lymph nodes. The diagnosis was also confirmed by immunophenotyping and histopathology of the cervical lymph nodes. The patient initially recieved FED chemotherapy (fludarabine, cyclophosphamide, dexamethasone) followed by elective autologous hematopoietic stem cell transplantation. In April 2009 the patient was hospitalized because of fever, pancytopenia, hyperbilirubinemia and peripheral lymphadenopathy. The FNAC of the enlarged cervical lymph nodes was performed again, but this time the smears were composed of polymorphous population of lymphocytes with the predomination of large cells, CD20+ on immunocytochemical stains. The immunophenotyping confirmed a predomination of monoclonal mature B-cells. Patient had high number of EBV DNA copies in plasma and serologic testing revealed increased titers of EBV VCA IgG and EBV EBNA IgG. CHOP-R chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) was then administered, resulting in good partial response of the disease. Reduced intensity allogeneic stem cell transplantation performed thereafter, resulted in complete remission of the disease. AITL is a rare lymphoproliferative disorder in which the neoplastic T-cells represent the minority of the lymph node cell population and almost all cases harbor EBV-infected B-cells. Various authors postulated that immunodeficiency in AITL patients together with immunosuppressive effects of cytotoxic drugs, may be responsible for EBV-induced proliferation of latently or newly EBV-infected B-cells with eventual clonal selection and progression to aggressive B-cell lymphoma." @default.
- W2117042893 created "2016-06-24" @default.
- W2117042893 creator A5033103275 @default.
- W2117042893 creator A5038299892 @default.
- W2117042893 creator A5041531471 @default.
- W2117042893 creator A5059990245 @default.
- W2117042893 creator A5067261991 @default.
- W2117042893 creator A5091291697 @default.
- W2117042893 date "2010-03-01" @default.
- W2117042893 modified "2023-09-23" @default.
- W2117042893 title "Diffuse large B-cell lymphoma in patient after treatment of angioimmunoblastic T-cell lymphoma." @default.
- W2117042893 cites W1605230984 @default.
- W2117042893 cites W2117754708 @default.
- W2117042893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20432757" @default.
- W2117042893 hasPublicationYear "2010" @default.
- W2117042893 type Work @default.
- W2117042893 sameAs 2117042893 @default.
- W2117042893 citedByCount "7" @default.
- W2117042893 countsByYear W21170428932014 @default.
- W2117042893 countsByYear W21170428932015 @default.
- W2117042893 countsByYear W21170428932018 @default.
- W2117042893 countsByYear W21170428932019 @default.
- W2117042893 countsByYear W21170428932020 @default.
- W2117042893 countsByYear W21170428932022 @default.
- W2117042893 countsByYear W21170428932023 @default.
- W2117042893 crossrefType "journal-article" @default.
- W2117042893 hasAuthorship W2117042893A5033103275 @default.
- W2117042893 hasAuthorship W2117042893A5038299892 @default.
- W2117042893 hasAuthorship W2117042893A5041531471 @default.
- W2117042893 hasAuthorship W2117042893A5059990245 @default.
- W2117042893 hasAuthorship W2117042893A5067261991 @default.
- W2117042893 hasAuthorship W2117042893A5091291697 @default.
- W2117042893 hasConcept C126322002 @default.
- W2117042893 hasConcept C142724271 @default.
- W2117042893 hasConcept C190283241 @default.
- W2117042893 hasConcept C196166836 @default.
- W2117042893 hasConcept C203014093 @default.
- W2117042893 hasConcept C206631613 @default.
- W2117042893 hasConcept C2776090121 @default.
- W2117042893 hasConcept C2776365654 @default.
- W2117042893 hasConcept C2776694085 @default.
- W2117042893 hasConcept C2776755627 @default.
- W2117042893 hasConcept C2779338263 @default.
- W2117042893 hasConcept C2779429289 @default.
- W2117042893 hasConcept C2779725641 @default.
- W2117042893 hasConcept C2908647359 @default.
- W2117042893 hasConcept C31573885 @default.
- W2117042893 hasConcept C553184892 @default.
- W2117042893 hasConcept C55493867 @default.
- W2117042893 hasConcept C71924100 @default.
- W2117042893 hasConcept C86803240 @default.
- W2117042893 hasConcept C8891405 @default.
- W2117042893 hasConcept C99454951 @default.
- W2117042893 hasConceptScore W2117042893C126322002 @default.
- W2117042893 hasConceptScore W2117042893C142724271 @default.
- W2117042893 hasConceptScore W2117042893C190283241 @default.
- W2117042893 hasConceptScore W2117042893C196166836 @default.
- W2117042893 hasConceptScore W2117042893C203014093 @default.
- W2117042893 hasConceptScore W2117042893C206631613 @default.
- W2117042893 hasConceptScore W2117042893C2776090121 @default.
- W2117042893 hasConceptScore W2117042893C2776365654 @default.
- W2117042893 hasConceptScore W2117042893C2776694085 @default.
- W2117042893 hasConceptScore W2117042893C2776755627 @default.
- W2117042893 hasConceptScore W2117042893C2779338263 @default.
- W2117042893 hasConceptScore W2117042893C2779429289 @default.
- W2117042893 hasConceptScore W2117042893C2779725641 @default.
- W2117042893 hasConceptScore W2117042893C2908647359 @default.
- W2117042893 hasConceptScore W2117042893C31573885 @default.
- W2117042893 hasConceptScore W2117042893C553184892 @default.
- W2117042893 hasConceptScore W2117042893C55493867 @default.
- W2117042893 hasConceptScore W2117042893C71924100 @default.
- W2117042893 hasConceptScore W2117042893C86803240 @default.
- W2117042893 hasConceptScore W2117042893C8891405 @default.
- W2117042893 hasConceptScore W2117042893C99454951 @default.
- W2117042893 hasIssue "1" @default.
- W2117042893 hasLocation W21170428931 @default.
- W2117042893 hasOpenAccess W2117042893 @default.
- W2117042893 hasPrimaryLocation W21170428931 @default.
- W2117042893 hasRelatedWork W1527313873 @default.
- W2117042893 hasRelatedWork W1886884175 @default.
- W2117042893 hasRelatedWork W1966567305 @default.
- W2117042893 hasRelatedWork W1990506912 @default.
- W2117042893 hasRelatedWork W1994668260 @default.
- W2117042893 hasRelatedWork W2019502863 @default.
- W2117042893 hasRelatedWork W2022966684 @default.
- W2117042893 hasRelatedWork W2047156935 @default.
- W2117042893 hasRelatedWork W2101155479 @default.
- W2117042893 hasRelatedWork W2139172440 @default.
- W2117042893 hasRelatedWork W2139548296 @default.
- W2117042893 hasRelatedWork W2149229675 @default.
- W2117042893 hasRelatedWork W2163971371 @default.
- W2117042893 hasRelatedWork W2168074191 @default.
- W2117042893 hasRelatedWork W2171120486 @default.
- W2117042893 hasRelatedWork W2318706857 @default.
- W2117042893 hasRelatedWork W2395471623 @default.
- W2117042893 hasRelatedWork W2472502148 @default.
- W2117042893 hasRelatedWork W2493435663 @default.
- W2117042893 hasRelatedWork W932775672 @default.