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• W2117053399 abstract "Pancreatic acini secrete digestive enzymes in response to a variety of secretagogues including CCK and agonists acting via proteinase-activated receptor-2 (PAR2). We employed the CCK analog caerulein and the PAR2-activating peptide SLIGRL-NH 2 to compare and contrast Ca 2+ changes and amylase secretion triggered by CCK receptor and PAR2 stimulation. We found that secretion stimulated by both agonists is dependent on a rise in cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ) and that this rise in [Ca 2+ ] i reflects both the release of Ca 2+ from intracellular stores and accelerated Ca 2+ influx. Both agonists, at low concentrations, elicit oscillatory [Ca 2+ ] i changes, and both trigger a peak plateau [Ca 2+ ] i change at high concentrations. Although the two agonists elicit similar rates of amylase secretion, the rise in [Ca 2+ ] i elicited by caerulein is greater than that elicited by SLIGRL-NH 2 . In Ca 2+ -free medium, the rise in [Ca 2+ ] i elicited by SLIGRL-NH 2 is prevented by the prior addition of a supramaximally stimulating concentration of caerulein, but the reverse is not true; the rise elicited by caerulein is neither prevented nor reduced by prior addition of SLIGRL-NH 2 . Both the oscillatory and the peak plateau [Ca 2+ ] i changes that follow PAR2 stimulation are prevented by the phospholipase C (PLC) inhibitor U73122, but U73122 prevents only the oscillatory [Ca 2+ ] i changes triggered by caerulein. We conclude that 1) both PAR2 and CCK stimulation trigger amylase secretion that is dependent on a rise in [Ca 2+ ] i and that [Ca 2+ ] i rise reflects release of calcium from intracellular stores as well as accelerated influx of extracellular calcium; 2) PLC mediates both the oscillatory and the peak plateau rise in [Ca 2+ ] i elicited by PAR2 but only the oscillatory rise in [Ca 2+ ] i elicited by CCK stimulation; and 3) the rate of amylase secretion elicited by agonists acting via different types of receptors may not correlate with the magnitude of the [Ca 2+ ] i rise triggered by those different types of secretagogue." @default.
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• W2117053399 date "2005-10-01" @default.
• W2117053399 modified "2023-09-23" @default.
• W2117053399 title "Calcium dependence of proteinase-activated receptor 2 and cholecystokinin- mediated amylase secretion from pancreatic acini" @default.
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• W2117053399 doi "https://doi.org/10.1152/ajpgi.00342.2004" @default.
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