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• W2117054922 abstract "The effect of pertussis toxin (PT) on transforming growth factor β1 (TGFβl)-induced proto-oncogene expression was investigated in AKR-2B fibroblasts. PT substantially abolished c-sis and c-myc mRNA expression following TGFβl stimulation. This inhibitory effect was specific for TGFβ1-stimulated proto-oncogene expression and associated with the ADP-ribosylation of a 41-kDa substrate. Actinomycin D decay and nuclear run-on experiments demonstrated that the inhibitory effects of PT are a result of decreased transcriptional activation and not to an increased decay of proto-oncogene message. PT did not, however, affect TGFβl-stimulated fibronectin and collagen mRNA accumulation nor did it have any inhibitory effect on TGFβl-induced morphological transformation. These data indicate that TGFβl-stimulated gene expression is coupled to multiple pathways distinguished by their sensitivity to PT." @default.
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• W2117054922 date "1990-01-01" @default.
• W2117054922 modified "2023-09-25" @default.
• W2117054922 title "Distinct pathways regulate transforming growth factor ?1-stimulated proto-oncogene and extracellular matrix gene expression" @default.
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• W2117054922 doi "https://doi.org/10.1002/jcp.1041420106" @default.
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