FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117058045> ?p ?o ?g. }

• W2117058045 endingPage "169" @default.
• W2117058045 startingPage "160" @default.
• W2117058045 abstract "The mechanisms underlying the action of estrogens in the fetal testis are still largely obscure. In particular, whether this action is direct or indirect remains largely unexplored. This study was aimed at investigating the effect of estradiol (E2) and diethylstilbestrol (DES) on the testis from 14.5-day-old rat fetuses in culture, at concentrations ranging from 4 x 10(-10) M (Kd of E2 for the estrogen receptors [ER]: 1-4 x 10(-10) M) to 4 x 10(-6) M (concentration previously shown in the literature to affect in vitro gonocyte proliferation). Exposure to DES and E2 decreased gonocyte number, the effects of DES being much more drastic than those of E2. Gonocyte number decreased in a concentration-dependent manner (day 3: -5%, -16%, and -80% at 4 x 10(-10) M, 4 x 10(-8) M, and 4 x 10(-6)M of DES, respectively), as well as in a time-dependent manner (at 4 x 10(-6) M DES: -31% on day 1, -60% on day 2, and -80% on day 3). This was due to a decrease in the gonocyte mitotic index and a dramatic increase in apoptosis. Importantly, in the presence of the anti-estrogen ICI 182.780 (ICI), the effect of DES was abolished. Sertoli cell number subsequently decreased (day 3), although the rate of apoptosis did not increase. These changes were less dramatic than those observed with gonocytes and were due to a decrease in Sertoli cell proliferation, which was not antagonized by ICI. Addition of 4 x 10(-6) M DES had no effect on basal Sertoli cell cyclic adenosine 5'-monophosphate (cAMP) levels or on follicle-stimulating hormone (FSH)-stimulated cAMP production after adjustment for Sertoli cell number. Finally, estrogens reduced both Leydig cell number (-26% on day 3, 4 x 10(-6) M DES) and basal and luteinizing hormone (LH)-stimulated testosterone production. The latter effects were antagonized by ICI.1) E2 and DES induce alterations in the germ line and in somatic cells; 2) gonocyte alteration was the first event detected, and the action of estrogens at this level was mediated by ER, as is the case in Leydig cells; and 3) these data should help us to understand estrogen effects on the fetus and should be considered in the context of the debate on environmental estrogens." @default.
• W2117058045 created "2016-06-24" @default.
• W2117058045 creator A5024875618 @default.
• W2117058045 creator A5030319323 @default.
• W2117058045 creator A5044571904 @default.
• W2117058045 creator A5053877774 @default.
• W2117058045 date "2003-03-25" @default.
• W2117058045 modified "2023-10-16" @default.
• W2117058045 title "Time- and Dose-Related Effects of Estradiol and Diethylstilbestrol on the Morphology and Function of the Fetal Rat Testis in Culture" @default.
• W2117058045 cites W135898729 @default.
• W2117058045 cites W1492788666 @default.
• W2117058045 cites W1532771022 @default.
• W2117058045 cites W1547137876 @default.
• W2117058045 cites W191894387 @default.
• W2117058045 cites W1963785171 @default.
• W2117058045 cites W1979274838 @default.
• W2117058045 cites W1979666006 @default.
• W2117058045 cites W1988719974 @default.
• W2117058045 cites W1990721641 @default.
• W2117058045 cites W1991473296 @default.
• W2117058045 cites W1992677740 @default.
• W2117058045 cites W2001090572 @default.
• W2117058045 cites W2004865397 @default.
• W2117058045 cites W2018633308 @default.
• W2117058045 cites W2023547801 @default.
• W2117058045 cites W2023822954 @default.
• W2117058045 cites W2026254092 @default.
• W2117058045 cites W2027208794 @default.
• W2117058045 cites W2033616764 @default.
• W2117058045 cites W2040877330 @default.
• W2117058045 cites W2041967555 @default.
• W2117058045 cites W2042226814 @default.
• W2117058045 cites W2054267961 @default.
• W2117058045 cites W2061188705 @default.
• W2117058045 cites W2063646727 @default.
• W2117058045 cites W2068500779 @default.
• W2117058045 cites W2073264207 @default.
• W2117058045 cites W2073883348 @default.
• W2117058045 cites W2074305712 @default.
• W2117058045 cites W2075296693 @default.
• W2117058045 cites W2085511343 @default.
• W2117058045 cites W2094119132 @default.
• W2117058045 cites W2102577321 @default.
• W2117058045 cites W2108059256 @default.
• W2117058045 cites W2112856057 @default.
• W2117058045 cites W2118368182 @default.
• W2117058045 cites W2140870683 @default.
• W2117058045 cites W2142158215 @default.
• W2117058045 cites W2144798445 @default.
• W2117058045 cites W2153435773 @default.
• W2117058045 cites W2153596741 @default.
• W2117058045 cites W2158649743 @default.
• W2117058045 cites W2188984405 @default.
• W2117058045 cites W2412989477 @default.
• W2117058045 cites W2436004988 @default.
• W2117058045 cites W2977503837 @default.
• W2117058045 cites W60875908 @default.
• W2117058045 doi "https://doi.org/10.1093/toxsci/kfg065" @default.
• W2117058045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12657744" @default.
• W2117058045 hasPublicationYear "2003" @default.
• W2117058045 type Work @default.
• W2117058045 sameAs 2117058045 @default.
• W2117058045 citedByCount "79" @default.
• W2117058045 countsByYear W21170580452012 @default.
• W2117058045 countsByYear W21170580452013 @default.
• W2117058045 countsByYear W21170580452014 @default.
• W2117058045 countsByYear W21170580452015 @default.
• W2117058045 countsByYear W21170580452016 @default.
• W2117058045 countsByYear W21170580452017 @default.
• W2117058045 countsByYear W21170580452018 @default.
• W2117058045 countsByYear W21170580452019 @default.
• W2117058045 countsByYear W21170580452020 @default.
• W2117058045 countsByYear W21170580452021 @default.
• W2117058045 countsByYear W21170580452022 @default.
• W2117058045 crossrefType "journal-article" @default.
• W2117058045 hasAuthorship W2117058045A5024875618 @default.
• W2117058045 hasAuthorship W2117058045A5030319323 @default.
• W2117058045 hasAuthorship W2117058045A5044571904 @default.
• W2117058045 hasAuthorship W2117058045A5053877774 @default.
• W2117058045 hasConcept C121608353 @default.
• W2117058045 hasConcept C123765429 @default.
• W2117058045 hasConcept C126322002 @default.
• W2117058045 hasConcept C134018914 @default.
• W2117058045 hasConcept C16685009 @default.
• W2117058045 hasConcept C172680121 @default.
• W2117058045 hasConcept C185592680 @default.
• W2117058045 hasConcept C190283241 @default.
• W2117058045 hasConcept C2777164284 @default.
• W2117058045 hasConcept C2777736315 @default.
• W2117058045 hasConcept C2778575703 @default.
• W2117058045 hasConcept C2779234561 @default.
• W2117058045 hasConcept C2781068068 @default.
• W2117058045 hasConcept C2781397067 @default.
• W2117058045 hasConcept C530470458 @default.
• W2117058045 hasConcept C54355233 @default.
• W2117058045 hasConcept C55493867 @default.
• W2117058045 hasConcept C62112901 @default.
• W2117058045 hasConcept C66640590 @default.

• next