Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117067508> ?p ?o ?g. }
- W2117067508 endingPage "155" @default.
- W2117067508 startingPage "141" @default.
- W2117067508 abstract "Thiazolidinediones are increasingly used drugs for the treatment of Type 2 diabetes. The individual response to thiazolidinedione therapy, ranging from the variable degree of metabolic improvement to harmful side-effects, is empirical, yet the underlying mechanisms remain elusive. In order to assess the pharmacogenomic component of thiazolidinediones' metabolic action, we compared the effect of rosiglitazone in two genetically defined models of metabolic syndrome, polydactylous (PD) and BN.SHR4 inbred rat strains, with their insulin-sensitive, normolipidemic counterpart, the Brown Norway (BN) rat.5-month-old male rats were fed a high-fat diet for 4 weeks, and the experimental groups received rosiglitazone (0.4 mg/100 g body weight) during the last 2 weeks of high-fat diet feeding. We assessed metabolic and morphometric profiles, oxidative stress parameters and gene expression in white adipose tissue.In many followed parameters, we observed genetic background-specific effects of rosiglitazone administration. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with rosiglitazone treatment only in PD, correlating with a PD-specific significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains, although fasting plasma glucose was increased by rosiglitazone in BN and BN.SHR4. Among the markers of lipid peroxidation, we observed the rosiglitazone-driven increase of plasma-conjugated dienes only in BN.SHR4. The genes with genotype-specific expression change included ADAM metallopeptidase domain 7, aquaporin 9, carnitine palmitoyltransferase 1B, caveolin 1, catechol-O-methyl transferase, leptin and prostaglandin D2 synthase 2.Rosiglitazone's effects on lipid deposition and insulin sensitivity of peripheral tissues are largely dependent on the genetic background it acts upon." @default.
- W2117067508 created "2016-06-24" @default.
- W2117067508 creator A5010591041 @default.
- W2117067508 creator A5025572908 @default.
- W2117067508 creator A5028626429 @default.
- W2117067508 creator A5039985404 @default.
- W2117067508 creator A5052203036 @default.
- W2117067508 creator A5053551803 @default.
- W2117067508 creator A5057368835 @default.
- W2117067508 creator A5083791988 @default.
- W2117067508 creator A5091556141 @default.
- W2117067508 date "2008-02-01" @default.
- W2117067508 modified "2023-09-27" @default.
- W2117067508 title "Pharmacogenomics of metabolic effects of rosiglitazone" @default.
- W2117067508 cites W1552044923 @default.
- W2117067508 cites W1838763289 @default.
- W2117067508 cites W1937194455 @default.
- W2117067508 cites W1965279819 @default.
- W2117067508 cites W1972136146 @default.
- W2117067508 cites W1976942305 @default.
- W2117067508 cites W1979369530 @default.
- W2117067508 cites W1980053858 @default.
- W2117067508 cites W1980460430 @default.
- W2117067508 cites W1981331323 @default.
- W2117067508 cites W1982311681 @default.
- W2117067508 cites W1983128420 @default.
- W2117067508 cites W1986683193 @default.
- W2117067508 cites W1990695275 @default.
- W2117067508 cites W1993251619 @default.
- W2117067508 cites W1997737330 @default.
- W2117067508 cites W2000821877 @default.
- W2117067508 cites W2003389247 @default.
- W2117067508 cites W2009383056 @default.
- W2117067508 cites W2010774685 @default.
- W2117067508 cites W2016472327 @default.
- W2117067508 cites W2022473709 @default.
- W2117067508 cites W2027380968 @default.
- W2117067508 cites W2031079527 @default.
- W2117067508 cites W2050360984 @default.
- W2117067508 cites W2054115426 @default.
- W2117067508 cites W2057371224 @default.
- W2117067508 cites W2059101048 @default.
- W2117067508 cites W2062769869 @default.
- W2117067508 cites W2066004325 @default.
- W2117067508 cites W2074881183 @default.
- W2117067508 cites W2081276121 @default.
- W2117067508 cites W2082407017 @default.
- W2117067508 cites W2090293136 @default.
- W2117067508 cites W2091809464 @default.
- W2117067508 cites W2091863647 @default.
- W2117067508 cites W2095770480 @default.
- W2117067508 cites W2097466966 @default.
- W2117067508 cites W2098132645 @default.
- W2117067508 cites W2098328918 @default.
- W2117067508 cites W2099930553 @default.
- W2117067508 cites W2103156933 @default.
- W2117067508 cites W2105700895 @default.
- W2117067508 cites W2108244474 @default.
- W2117067508 cites W2108598204 @default.
- W2117067508 cites W2116265489 @default.
- W2117067508 cites W2121881643 @default.
- W2117067508 cites W2126327417 @default.
- W2117067508 cites W2127125241 @default.
- W2117067508 cites W2127954231 @default.
- W2117067508 cites W2128080366 @default.
- W2117067508 cites W2128899850 @default.
- W2117067508 cites W2134558662 @default.
- W2117067508 cites W2148783362 @default.
- W2117067508 cites W2156248522 @default.
- W2117067508 cites W2159214791 @default.
- W2117067508 cites W2160234571 @default.
- W2117067508 cites W2162658847 @default.
- W2117067508 cites W2165149014 @default.
- W2117067508 cites W2165476644 @default.
- W2117067508 cites W2168301815 @default.
- W2117067508 cites W2169740931 @default.
- W2117067508 cites W4240449862 @default.
- W2117067508 doi "https://doi.org/10.2217/14622416.9.2.141" @default.
- W2117067508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18370844" @default.
- W2117067508 hasPublicationYear "2008" @default.
- W2117067508 type Work @default.
- W2117067508 sameAs 2117067508 @default.
- W2117067508 citedByCount "19" @default.
- W2117067508 countsByYear W21170675082012 @default.
- W2117067508 countsByYear W21170675082014 @default.
- W2117067508 countsByYear W21170675082015 @default.
- W2117067508 countsByYear W21170675082016 @default.
- W2117067508 countsByYear W21170675082017 @default.
- W2117067508 countsByYear W21170675082018 @default.
- W2117067508 countsByYear W21170675082022 @default.
- W2117067508 crossrefType "journal-article" @default.
- W2117067508 hasAuthorship W2117067508A5010591041 @default.
- W2117067508 hasAuthorship W2117067508A5025572908 @default.
- W2117067508 hasAuthorship W2117067508A5028626429 @default.
- W2117067508 hasAuthorship W2117067508A5039985404 @default.
- W2117067508 hasAuthorship W2117067508A5052203036 @default.
- W2117067508 hasAuthorship W2117067508A5053551803 @default.
- W2117067508 hasAuthorship W2117067508A5057368835 @default.