FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117082349> ?p ?o ?g. }

• W2117082349 endingPage "207" @default.
• W2117082349 startingPage "198" @default.
• W2117082349 abstract "Pulmonary hypertension is a progressive disease characterized by marked pulmonary arterial remodeling and increased vascular resistance. Inflammation and oxidative stress promote the development of pulmonary hypertension. Oxymatrine, one of the main active components of the Chinese herb Sophora flavescens Ait. (Kushen), plays anti-inflammatory and antioxidant protective roles, which effects on pulmonary arteries remain unclear. This study aimed to investigate the effects of oxymatrine on pulmonary hypertension development. Sprague-Dawley rats were exposed to hypoxia for 28 days or injected with monocrotaline, to develop pulmonary hypertension, along with administration of oxymatrine (50mg/kg/day). Hemodynamics and pulmonary arterial remodeling data from the rats were then obtained. The antiproliferative effect of oxymatrine was verified by in vitro assays. The inflammatory cytokine mRNA levels and leukocyte and T cell accumulation in lung tissue were detected. The antioxidative effects of oxymatrine were explored in vitro. Our study shows that oxymatrine treatment attenuated right-ventricular systolic pressure and pulmonary arterial remodeling induced by hypoxia or monocrotaline and inhibited proliferation of pulmonary arterial smooth muscle cells (PASMCs). Increased expression of inflammatory cytokine mRNA and accumulation of leukocytes and T cells around the pulmonary arteries were suppressed with oxymatrine administration. Under hypoxic conditions, oxymatrine significantly upregulated Nrf2 and antioxidant protein SOD1 and HO-1 expression, but downregulated hydroperoxide levels in PASMCs. In summary, this study indicates that oxymatrine may prevent pulmonary hypertension through its antiproliferative, anti-inflammatory, and antioxidant effects, thus providing a promising pharmacological avenue for treating pulmonary hypertension." @default.
• W2117082349 created "2016-06-24" @default.
• W2117082349 creator A5003849480 @default.
• W2117082349 creator A5003866201 @default.
• W2117082349 creator A5004059954 @default.
• W2117082349 creator A5006576189 @default.
• W2117082349 creator A5006842513 @default.
• W2117082349 creator A5011877804 @default.
• W2117082349 creator A5031597539 @default.
• W2117082349 creator A5050772776 @default.
• W2117082349 creator A5061027489 @default.
• W2117082349 creator A5065481111 @default.
• W2117082349 creator A5069067272 @default.
• W2117082349 creator A5082631360 @default.
• W2117082349 creator A5089959663 @default.
• W2117082349 date "2014-04-01" @default.
• W2117082349 modified "2023-10-17" @default.
• W2117082349 title "Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats" @default.
• W2117082349 cites W1834852860 @default.
• W2117082349 cites W1971494232 @default.
• W2117082349 cites W1971839986 @default.
• W2117082349 cites W1975240939 @default.
• W2117082349 cites W1987948630 @default.
• W2117082349 cites W1987960880 @default.
• W2117082349 cites W1991067458 @default.
• W2117082349 cites W1992900987 @default.
• W2117082349 cites W2002660236 @default.
• W2117082349 cites W2003983395 @default.
• W2117082349 cites W2010282977 @default.
• W2117082349 cites W2016512961 @default.
• W2117082349 cites W2017499001 @default.
• W2117082349 cites W2020277250 @default.
• W2117082349 cites W2022060260 @default.
• W2117082349 cites W2022205209 @default.
• W2117082349 cites W2023703380 @default.
• W2117082349 cites W2025593289 @default.
• W2117082349 cites W2026469629 @default.
• W2117082349 cites W2049772449 @default.
• W2117082349 cites W2053350368 @default.
• W2117082349 cites W2060254175 @default.
• W2117082349 cites W2066890260 @default.
• W2117082349 cites W2075866596 @default.
• W2117082349 cites W2076052106 @default.
• W2117082349 cites W2090596239 @default.
• W2117082349 cites W2092266379 @default.
• W2117082349 cites W2094303363 @default.
• W2117082349 cites W2096718392 @default.
• W2117082349 cites W2112342981 @default.
• W2117082349 cites W2131601314 @default.
• W2117082349 cites W2133931336 @default.
• W2117082349 cites W2145237733 @default.
• W2117082349 cites W2145357984 @default.
• W2117082349 cites W2147854094 @default.
• W2117082349 cites W2161877652 @default.
• W2117082349 cites W2165946847 @default.
• W2117082349 cites W2166431337 @default.
• W2117082349 cites W2170478368 @default.
• W2117082349 cites W2273663629 @default.
• W2117082349 cites W2331176038 @default.
• W2117082349 doi "https://doi.org/10.1016/j.freeradbiomed.2014.01.013" @default.
• W2117082349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440469" @default.
• W2117082349 hasPublicationYear "2014" @default.
• W2117082349 type Work @default.
• W2117082349 sameAs 2117082349 @default.
• W2117082349 citedByCount "33" @default.
• W2117082349 countsByYear W21170823492012 @default.
• W2117082349 countsByYear W21170823492015 @default.
• W2117082349 countsByYear W21170823492016 @default.
• W2117082349 countsByYear W21170823492017 @default.
• W2117082349 countsByYear W21170823492018 @default.
• W2117082349 countsByYear W21170823492019 @default.
• W2117082349 countsByYear W21170823492020 @default.
• W2117082349 countsByYear W21170823492021 @default.
• W2117082349 countsByYear W21170823492022 @default.
• W2117082349 countsByYear W21170823492023 @default.
• W2117082349 crossrefType "journal-article" @default.
• W2117082349 hasAuthorship W2117082349A5003849480 @default.
• W2117082349 hasAuthorship W2117082349A5003866201 @default.
• W2117082349 hasAuthorship W2117082349A5004059954 @default.
• W2117082349 hasAuthorship W2117082349A5006576189 @default.
• W2117082349 hasAuthorship W2117082349A5006842513 @default.
• W2117082349 hasAuthorship W2117082349A5011877804 @default.
• W2117082349 hasAuthorship W2117082349A5031597539 @default.
• W2117082349 hasAuthorship W2117082349A5050772776 @default.
• W2117082349 hasAuthorship W2117082349A5061027489 @default.
• W2117082349 hasAuthorship W2117082349A5065481111 @default.
• W2117082349 hasAuthorship W2117082349A5069067272 @default.
• W2117082349 hasAuthorship W2117082349A5082631360 @default.
• W2117082349 hasAuthorship W2117082349A5089959663 @default.
• W2117082349 hasConcept C118552586 @default.
• W2117082349 hasConcept C126322002 @default.
• W2117082349 hasConcept C178790620 @default.
• W2117082349 hasConcept C185592680 @default.
• W2117082349 hasConcept C2776245682 @default.
• W2117082349 hasConcept C2776545273 @default.
• W2117082349 hasConcept C2777714996 @default.
• W2117082349 hasConcept C2778484605 @default.
• W2117082349 hasConcept C2780930700 @default.

• next