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• W2117084434 endingPage "644S" @default.
• W2117084434 startingPage "627S" @default.
• W2117084434 abstract "This chapter about the use of antithrombotic agents during pregnancy is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual patients' values may lead to different choices (for a full understanding of the grading see Guyatt et al, CHEST 2004; 126:179S–187S). Among the key recommendations in this chapter are the following: for women requiring long-term vitamin K antagonist therapy who are attempting pregnancy, we suggest performing frequent pregnancy tests and substituting unfractionated heparin (UFH) or low molecular weight heparin (LMWH) for warfarin when pregnancy is achieved (Grade 2C). In women with acute venous thromboembolism (VTE), we recommend adjusted-dose LMWH throughout pregnancy or IV UFH for at least 5 days, followed by adjusted-dose UFH or LMWH for the remainder of the pregnancy and at least 6 weeks postpartum (Grade 1C+). In patients with a single episode of VTE associated with a transient risk factor that is no longer present, we recommend antepartum clinical surveillance and postpartum anticoagulants (Grade 1C). In patients with a single episode of VTE and thrombophilia or strong family history of thrombosis and not receiving long-term anticoagulants, we suggest antepartum prophylactic or intermediate-dose LMWH or minidose or moderate-dose UFH, plus postpartum anticoagulants (Grade 2C). In patients with multiple (two or more) episodes of VTE and/or women receiving long-term anticoagulants, we suggest antepartum adjusted-dose UFH or adjusted-dose LMWH followed by long-term anticoagulants postpartum (Grade 2C). For pregnant patients with antiphospholipid antibodies (APLAs) and a history of two or more early pregnancy losses or one or more late pregnancy losses, preeclampsia, intrauterine growth retardation, or abruption, we suggest antepartum aspirin plus minidose or moderate-dose UFH or prophylactic LMWH (Grade 2B). We suggest one of the following approaches for women with APLAs without prior VTE or pregnancy loss: surveillance, minidose heparin, prophylactic LMWH, and/or low-dose aspirin, 75 to 325 mg/d (all Grade 2C). In women with prosthetic heart valves, we recommend adjusted-dose bid LMWH throughout pregnancy (Grade 1C), aggressive adjusted-dose UFH throughout pregnancy (Grade 1C), or UFH or LMWH until the thirteenth week and then change to warfarin until the middle of the third trimester before restarting UFH or LMWH (Grade 1C). In high-risk women with prosthetic heart valves, we suggest the addition of low-dose aspirin, 75 to 162 mg/d (Grade 2C). This chapter about the use of antithrombotic agents during pregnancy is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual patients' values may lead to different choices (for a full understanding of the grading see Guyatt et al, CHEST 2004; 126:179S–187S). Among the key recommendations in this chapter are the following: for women requiring long-term vitamin K antagonist therapy who are attempting pregnancy, we suggest performing frequent pregnancy tests and substituting unfractionated heparin (UFH) or low molecular weight heparin (LMWH) for warfarin when pregnancy is achieved (Grade 2C). In women with acute venous thromboembolism (VTE), we recommend adjusted-dose LMWH throughout pregnancy or IV UFH for at least 5 days, followed by adjusted-dose UFH or LMWH for the remainder of the pregnancy and at least 6 weeks postpartum (Grade 1C+). In patients with a single episode of VTE associated with a transient risk factor that is no longer present, we recommend antepartum clinical surveillance and postpartum anticoagulants (Grade 1C). In patients with a single episode of VTE and thrombophilia or strong family history of thrombosis and not receiving long-term anticoagulants, we suggest antepartum prophylactic or intermediate-dose LMWH or minidose or moderate-dose UFH, plus postpartum anticoagulants (Grade 2C). In patients with multiple (two or more) episodes of VTE and/or women receiving long-term anticoagulants, we suggest antepartum adjusted-dose UFH or adjusted-dose LMWH followed by long-term anticoagulants postpartum (Grade 2C). For pregnant patients with antiphospholipid antibodies (APLAs) and a history of two or more early pregnancy losses or one or more late pregnancy losses, preeclampsia, intrauterine growth retardation, or abruption, we suggest antepartum aspirin plus minidose or moderate-dose UFH or prophylactic LMWH (Grade 2B). We suggest one of the following approaches for women with APLAs without prior VTE or pregnancy loss: surveillance, minidose heparin, prophylactic LMWH, and/or low-dose aspirin, 75 to 325 mg/d (all Grade 2C). In women with prosthetic heart valves, we recommend adjusted-dose bid LMWH throughout pregnancy (Grade 1C), aggressive adjusted-dose UFH throughout pregnancy (Grade 1C), or UFH or LMWH until the thirteenth week and then change to warfarin until the middle of the third trimester before restarting UFH or LMWH (Grade 1C). In high-risk women with prosthetic heart valves, we suggest the addition of low-dose aspirin, 75 to 162 mg/d (Grade 2C)." @default.
• W2117084434 created "2016-06-24" @default.
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• W2117084434 date "2004-09-01" @default.
• W2117084434 modified "2023-10-16" @default.
• W2117084434 title "Use of Antithrombotic Agents During Pregnancy" @default.
• W2117084434 cites W131809637 @default.
• W2117084434 cites W1483107031 @default.
• W2117084434 cites W1491912188 @default.
• W2117084434 cites W1542673764 @default.
• W2117084434 cites W1589820399 @default.
• W2117084434 cites W166283786 @default.
• W2117084434 cites W1725341244 @default.
• W2117084434 cites W1809808456 @default.
• W2117084434 cites W1875541132 @default.
• W2117084434 cites W1893479320 @default.
• W2117084434 cites W1967550469 @default.
• W2117084434 cites W1970051571 @default.
• W2117084434 cites W1971933809 @default.
• W2117084434 cites W1975628470 @default.
• W2117084434 cites W1976108666 @default.
• W2117084434 cites W1980621470 @default.
• W2117084434 cites W1983031062 @default.
• W2117084434 cites W1984833612 @default.
• W2117084434 cites W1987387857 @default.
• W2117084434 cites W1989266331 @default.
• W2117084434 cites W1994709901 @default.
• W2117084434 cites W2000296190 @default.
• W2117084434 cites W2001899027 @default.
• W2117084434 cites W2003127921 @default.
• W2117084434 cites W2004860469 @default.
• W2117084434 cites W2006716512 @default.
• W2117084434 cites W2015354888 @default.
• W2117084434 cites W2023219983 @default.
• W2117084434 cites W2024158672 @default.
• W2117084434 cites W2024198289 @default.
• W2117084434 cites W2039780016 @default.
• W2117084434 cites W2041709488 @default.
• W2117084434 cites W2043291602 @default.
• W2117084434 cites W2047929332 @default.
• W2117084434 cites W2050802944 @default.
• W2117084434 cites W2051551497 @default.
• W2117084434 cites W2051747647 @default.
• W2117084434 cites W2051848324 @default.
• W2117084434 cites W2055399083 @default.
• W2117084434 cites W2056040181 @default.
• W2117084434 cites W2061071054 @default.
• W2117084434 cites W2061920971 @default.
• W2117084434 cites W2061988623 @default.
• W2117084434 cites W2065791735 @default.
• W2117084434 cites W2067795755 @default.
• W2117084434 cites W2073330986 @default.
• W2117084434 cites W2073395553 @default.
• W2117084434 cites W2075196907 @default.
• W2117084434 cites W2084274763 @default.
• W2117084434 cites W2085060329 @default.
• W2117084434 cites W2085416491 @default.
• W2117084434 cites W2089037906 @default.
• W2117084434 cites W2091755086 @default.
• W2117084434 cites W2101226231 @default.
• W2117084434 cites W2109451688 @default.
• W2117084434 cites W2112019124 @default.
• W2117084434 cites W2115742352 @default.
• W2117084434 cites W2127062735 @default.
• W2117084434 cites W2136152362 @default.
• W2117084434 cites W2138444098 @default.
• W2117084434 cites W2139482299 @default.
• W2117084434 cites W2140152060 @default.
• W2117084434 cites W2143583040 @default.
• W2117084434 cites W2145308085 @default.
• W2117084434 cites W2146362586 @default.
• W2117084434 cites W2147759117 @default.
• W2117084434 cites W2150316597 @default.
• W2117084434 cites W2151172455 @default.
• W2117084434 cites W2156314756 @default.
• W2117084434 cites W2160439279 @default.
• W2117084434 cites W2187931449 @default.
• W2117084434 cites W2196887485 @default.
• W2117084434 cites W2252446512 @default.
• W2117084434 cites W2291260831 @default.
• W2117084434 cites W2312867046 @default.
• W2117084434 cites W2313752590 @default.
• W2117084434 cites W2314358062 @default.
• W2117084434 cites W2319326268 @default.
• W2117084434 cites W2320143189 @default.
• W2117084434 cites W2320798046 @default.
• W2117084434 cites W2329963748 @default.
• W2117084434 cites W2332065325 @default.
• W2117084434 cites W2333983635 @default.
• W2117084434 cites W2338244864 @default.
• W2117084434 cites W2339094875 @default.
• W2117084434 cites W2339659421 @default.
• W2117084434 cites W2417727379 @default.
• W2117084434 cites W2427297137 @default.
• W2117084434 cites W2462341569 @default.

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