FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117116940> ?p ?o ?g. }

• W2117116940 endingPage "244" @default.
• W2117116940 startingPage "227" @default.
• W2117116940 abstract "Seasonal influenza can be a self-limiting illness in healthy individuals but is associated with short-term morbidity and economic burden. Influenza can cause significant morbidity and mortality in young children, the elderly, pregnant and post-partum women, patients with co-morbidities and the immunocompromised. Neuraminidase inhibitors (NAIs) are the treatment of choice for influenza due to widespread resistance to the adamantanes. NAIs are efficacious for the treatment of influenza in ambulatory patients with mild illness, when initiated within 48 h of symptom onset. Early treatment with NAIs has been shown to reduce otitis media in children, and lower respiratory tract complications, resulting in antibiotic therapy, in adults. Evidence on the efficacy of NAIs for the prevention of influenza-related complications in at-risk populations, based on reviews of data from randomised trials is inconclusive. However, observational studies suggest that in hospitalised patients early treatment with NAIs has been associated with reduced mortality. NAIs should be initiated as soon as possible in patients at high-risk of influenza-related complications, with suspected or proven influenza, hospitalised patients and patients with severe or progressive disease. NAIs can be considered in previously healthy patients when therapy can be initiated within 48 h of symptom onset. In previously healthy patients, the therapeutic efficacy of oseltamivir is time-dependent, with maximal benefit observed when therapy is initiated within 48 h of symptom onset. However, several observational studies suggest therapeutic benefit beyond 48 h, in hospitalised patients, severe disease, and patients at high risk of complications, including pregnant women. NAIs should be considered in patients at high risk of influenza-related complications who present late. Further studies are needed to define the optimal timing of NAIs. Oseltamivir-resistant virus has been widely reported but is predominantly an issue in H1N1 seasonal influenza. Zanamivir-resistant influenza virus is rare, and inhaled or intravenous (IV) zanamivir is the treatment of choice in proven or suspected oseltamivir-resistant virus. Intubated patients with severe influenza can be treated with oseltamivir (suspension) administered via nasogastric tube. The commercial dry powder formulation of zanamivir should not be administered, via nebulisation, as it has been associated with ventilator malfunction and mortality. In intubated patients, when there are concerns about gastric absorption, IV zanamivir should be obtained under Emergency Investigational New Drug access schemes. Currently available evidence does not support the use of high-dose or extended-duration oseltamivir in patients with severe influenza, but does require further investigation. Extracorporeal membrane oxygenation has not been shown to be superior to conventional management in patients with influenza-associated acute respiratory distress syndrome and should be considered as salvage therapy. Corticosteriods should not be used in the treatment of severe influenza as this has been associated with increased risk of mortality and bacterial superinfection." @default.
• W2117116940 created "2016-06-24" @default.
• W2117116940 creator A5030935953 @default.
• W2117116940 creator A5043827008 @default.
• W2117116940 creator A5062132311 @default.
• W2117116940 creator A5074180951 @default.
• W2117116940 creator A5075384915 @default.
• W2117116940 date "2014-06-25" @default.
• W2117116940 modified "2023-09-26" @default.
• W2117116940 title "Seasonal Human Influenza: Treatment Options" @default.
• W2117116940 cites W1512165052 @default.
• W2117116940 cites W1691546288 @default.
• W2117116940 cites W1964402677 @default.
• W2117116940 cites W1965226808 @default.
• W2117116940 cites W1972064613 @default.
• W2117116940 cites W1976619973 @default.
• W2117116940 cites W1981730209 @default.
• W2117116940 cites W1985590897 @default.
• W2117116940 cites W1987783718 @default.
• W2117116940 cites W1989040943 @default.
• W2117116940 cites W1989837791 @default.
• W2117116940 cites W1989848714 @default.
• W2117116940 cites W1990085162 @default.
• W2117116940 cites W1990732836 @default.
• W2117116940 cites W1991622705 @default.
• W2117116940 cites W1992115679 @default.
• W2117116940 cites W1994775884 @default.
• W2117116940 cites W2000252758 @default.
• W2117116940 cites W2004554957 @default.
• W2117116940 cites W2006934056 @default.
• W2117116940 cites W2007165440 @default.
• W2117116940 cites W2008617110 @default.
• W2117116940 cites W2009545527 @default.
• W2117116940 cites W2011162259 @default.
• W2117116940 cites W2014050627 @default.
• W2117116940 cites W2014870322 @default.
• W2117116940 cites W2015396574 @default.
• W2117116940 cites W2023575018 @default.
• W2117116940 cites W2026201313 @default.
• W2117116940 cites W2027368298 @default.
• W2117116940 cites W2033996865 @default.
• W2117116940 cites W2035077104 @default.
• W2117116940 cites W2040634521 @default.
• W2117116940 cites W2040750927 @default.
• W2117116940 cites W2048271769 @default.
• W2117116940 cites W2060514161 @default.
• W2117116940 cites W2061134488 @default.
• W2117116940 cites W2062290406 @default.
• W2117116940 cites W2063205059 @default.
• W2117116940 cites W2063724081 @default.
• W2117116940 cites W2065420324 @default.
• W2117116940 cites W2066635136 @default.
• W2117116940 cites W2067681440 @default.
• W2117116940 cites W2078346244 @default.
• W2117116940 cites W2079623506 @default.
• W2117116940 cites W2082036062 @default.
• W2117116940 cites W2083804892 @default.
• W2117116940 cites W2088399547 @default.
• W2117116940 cites W2092237993 @default.
• W2117116940 cites W2096238447 @default.
• W2117116940 cites W2096445424 @default.
• W2117116940 cites W2099698280 @default.
• W2117116940 cites W2101225862 @default.
• W2117116940 cites W2101328245 @default.
• W2117116940 cites W2102263282 @default.
• W2117116940 cites W2103331025 @default.
• W2117116940 cites W2104397822 @default.
• W2117116940 cites W2106544866 @default.
• W2117116940 cites W2107569667 @default.
• W2117116940 cites W2108503373 @default.
• W2117116940 cites W2111005290 @default.
• W2117116940 cites W2112164609 @default.
• W2117116940 cites W2115053209 @default.
• W2117116940 cites W2116911900 @default.
• W2117116940 cites W2117026086 @default.
• W2117116940 cites W2119394949 @default.
• W2117116940 cites W2120436172 @default.
• W2117116940 cites W2120850985 @default.
• W2117116940 cites W2122677672 @default.
• W2117116940 cites W2124950712 @default.
• W2117116940 cites W2126822076 @default.
• W2117116940 cites W2129749447 @default.
• W2117116940 cites W2133701960 @default.
• W2117116940 cites W2134242383 @default.
• W2117116940 cites W2134841048 @default.
• W2117116940 cites W2135421762 @default.
• W2117116940 cites W2136402332 @default.
• W2117116940 cites W2139841300 @default.
• W2117116940 cites W2140187573 @default.
• W2117116940 cites W2141896297 @default.
• W2117116940 cites W2143292391 @default.
• W2117116940 cites W2145336467 @default.
• W2117116940 cites W2148958087 @default.
• W2117116940 cites W2150047295 @default.
• W2117116940 cites W2150092940 @default.
• W2117116940 cites W2154599034 @default.
• W2117116940 cites W2156506016 @default.
• W2117116940 cites W2157177671 @default.

• next