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W2117145430 abstract "<i >Introduction</i>. The aim of the present study was to compare the levels of circulating markers of endothelial function and low-grade inflammation in patients with subclinical and overt hyperthyroidism (OH) due to Graves disease (GD) and toxic nodular goiter (TNG). <i >Material and Methods</i>. The group studied consisted of 42 patients with GD, 75 patients with TNG, and 39 healthy controls. <i >Results</i>. Circulating markers of endothelial dysfunction were elevated in the patients with both SH and OH, but the concentrations of interleukin-12 (IL-12) (<svg style=vertical-align:-0.1638pt;width:58.712502px; id=M1 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><path id=x1D443 d=M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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t96 -62.5q53 0 78 45.5t25 105.5q0 68 -35 116t-99 48z /></g> </svg>, <svg style=vertical-align:-0.1638pt;width:58.712502px; id=M6 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x35/></g> </svg>), FT4 (<svg style=vertical-align:-0.1638pt;width:67.012497px; id=M7 height=11.375 version=1.1 viewBox=0 0 67.012497 11.375 width=67.012497 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D445/></g><g transform=matrix(.017,-0,0,-.017,15.718,11.112)><use xlink:href=#x3D/></g><g transform=matrix(.017,-0,0,-.017,30.422,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.582,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.457,11.112)><use xlink:href=#x32/></g><g transform=matrix(.017,-0,0,-.017,50.617,11.112)><use xlink:href=#x37/></g><g transform=matrix(.017,-0,0,-.017,58.776,11.112)><path id=x33 d=M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5
q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z /></g> </svg>, <svg style=vertical-align:-0.1638pt;width:58.712502px; id=M8 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x35/></g> </svg>), and thyroid peroxidase antibodies (<svg style=vertical-align:-0.1638pt;width:67.012497px; id=M9 height=11.375 version=1.1 viewBox=0 0 67.012497 11.375 width=67.012497 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D445/></g><g transform=matrix(.017,-0,0,-.017,15.718,11.112)><use xlink:href=#x3D/></g><g transform=matrix(.017,-0,0,-.017,30.422,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.582,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.457,11.112)><use xlink:href=#x33/></g><g transform=matrix(.017,-0,0,-.017,50.617,11.112)><path id=x34 d=M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z /></g><g transform=matrix(.017,-0,0,-.017,58.776,11.112)><use xlink:href=#x36/></g> </svg>, <svg style=vertical-align:-0.1638pt;width:58.712502px; id=M10 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x31/></g> </svg>) levels. <i >Conclusion</i>. Our results may suggest that both SH and OH may be associated with endothelial dysfunction, which is reflected by decreased fibrinolytic activity, hypercoagulability, and increased levels of IL-6, IL-12, and IL-18 and depends not only on the cause but also on the degree of hyperthyroidism." @default.
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W2117145430 date "2013-01-01" @default.
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W2117145430 title "The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism" @default.
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W2117145430 doi "https://doi.org/10.1155/2013/981638" @default.
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