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• W2117147825 abstract "The aim of this study was to access outcome and side effects of radiotherapeutic treatment of tongue cancer. In a retrospective analysis the treatment results of 72 patients (median age 55 years; 31 female, 42 male) with cancer of the mobile tongue (n=32) or tongue margins (n=40) treated between 1982 and 2006 were reviewed. The disease stage was as follows: T1 n=12, T2 n=37, T3 n=20,Tx n=3; N0 n=18, N1 n=19, N2 n=29, N3 n=1, Nx n=5; M0 n=54, Mx n=18). The treatment consisted of primary radiotherapy (n=49, median dose 60 Gy), neoadjuvant radiotherapy (n=23, median dose 40 Gy; additional postoperative dose escalation to median 68 Gy in 5 of these patients), platin-based chemotherapy (n=36) or immunotherapy (n=1) and surgery (tumor resection [n=49], neck dissection [n=37], suprahyoidal dissection [n=34]). After a median follow-up time of 22 months (range, 1-160 months) the 3- and 5-year overall survival rates were 55% and 43%, respectively. The median overall survival time was 47 months. Forty-two patients achieved complete remission whereas 15 patients showed partial remission, 3 patients showed no change and 2 patients had progressive disease after treatment. The 3-, 5- and 10-year loco-regional progression-free survival rates were 66%, 59% and 50%, respectively. The median loco-regional progression-free survival time was 70 months. Upon univariate analysis significantly improved survival was seen in patients without chronic alcohol abuse in their history (p = 0.009), with absence of tumor invasion into the contralateral part of the tongue (p = 0.036) and in the female gender (p = 0.043), borderline significance in T-stage (p = 0.068). In multivariate analysis, female gender (p = 0.034), a neoadjuvant radiation treatment (p = 0.029) and t-stage (p = 0.013) were prognostic. Regarding prognostic factors for local control, t-stage showed borderline significance in univariate analysis (p = 0.068) and significance in multivariate analysis (p = 0.015). Grade III/IV acute toxicity was seen in 47% of patients. None of the locally controlled patients reported grade IV or higher late toxicity. Causes of death were tumor progression (n = 13), medical conditions (n = 8), secondary carcinoma (n = 1) and undocumented reasons (n = 16). Radiotherapy in squamous cell carcinoma of the mobile tongue and tongue margins is an effective treatment option, especially as a neoadjuvant approach followed by surgical resection. A complete remission could be achieved in the majority of patients. Furthermore, none of the locally controlled patients reported grade IV or higher late toxicity." @default.
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• W2117147825 date "2010-11-01" @default.
• W2117147825 modified "2023-09-27" @default.
• W2117147825 title "Radiation Therapy in Cancer of the Oral Tongue or Tongue Margin" @default.
• W2117147825 doi "https://doi.org/10.1016/j.ijrobp.2010.07.1126" @default.
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