FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117148268> ?p ?o ?g. }

• W2117148268 endingPage "C666" @default.
• W2117148268 startingPage "C653" @default.
• W2117148268 abstract "The present study explores the hypothesis that arterial smooth muscle cells are organized into layers with similar phenotypic characteristics that vary with the relative position between the lumen and the adventitia due to transmural gradients in vasotrophic factors. A corollary hypothesis is that vascular endothelial growth factor (VEGF) is a factor that helps establish transmural variations in smooth muscle phenotype. Organ culture of endothelium-denuded ovine carotid arteries with 3 ng/ml VEGF-A 165 for 24 h differentially and significantly influenced potassium-induced (55% increase) and stretch-induced (36% decrease) stress-strain relations in adult ( n = 18) but not term fetal ( n = 21) arteries, suggesting that smooth muscle reactivity to VEGF is acquired during postnatal maturation. Because inclusion of fetal bovine serum significantly inhibited all contractile effects of VEGF (adult: n = 11; fetus: n = 11), it was excluded in all cultures. When assessed in relation to the distance between the lumen and the adventitia in immunohistochemically stained coronal artery sections, expression of smooth muscle α-actin (SMαA), myosin light chain kinase (MLCK), and 20-kDa regulatory myosin light chain exhibited distinct protein-dependent and age-dependent gradients across the artery wall. VEGF depressed regional SMαA abundance up to 15% in adult ( n = 6) but not in fetal ( n = 6) arteries, increased regional MLCK abundance up to 140% in fetal ( n = 8) but not in adult ( n = 10) arteries, and increased regional MLC 20 abundance up to 28% in fetal arteries ( n = 7) but decreased it by 17% in adult arteries ( n = 9). Measurements of mRNA levels verified that VEGF receptor transcripts for both Flt-1 and kinase insert domain receptor (KDR) were expressed in both fetal and adult arteries. Overall, the present data support the unique hypothesis that smooth muscle cells are organized into lamina of similar phenotype with characteristics that depend on the relative position between the lumen and the adventitia and involve the direct effects of growth factors such as VEGF, which acts independently of the vascular endothelium in an age-dependent manner." @default.
• W2117148268 created "2016-06-24" @default.
• W2117148268 creator A5002432241 @default.
• W2117148268 creator A5017373558 @default.
• W2117148268 creator A5025177747 @default.
• W2117148268 creator A5032544743 @default.
• W2117148268 creator A5037219635 @default.
• W2117148268 creator A5045441347 @default.
• W2117148268 creator A5064377405 @default.
• W2117148268 creator A5065145602 @default.
• W2117148268 creator A5082259652 @default.
• W2117148268 date "2011-09-01" @default.
• W2117148268 modified "2023-10-18" @default.
• W2117148268 title "Contributions of VEGF to age-dependent transmural gradients in contractile protein expression in ovine carotid arteries" @default.
• W2117148268 cites W1482082412 @default.
• W2117148268 cites W1528265869 @default.
• W2117148268 cites W1591576570 @default.
• W2117148268 cites W1604785797 @default.
• W2117148268 cites W1927563061 @default.
• W2117148268 cites W1949832432 @default.
• W2117148268 cites W1962154683 @default.
• W2117148268 cites W1966181655 @default.
• W2117148268 cites W1970165453 @default.
• W2117148268 cites W1972760800 @default.
• W2117148268 cites W1980755389 @default.
• W2117148268 cites W1980820166 @default.
• W2117148268 cites W1983763042 @default.
• W2117148268 cites W1987522740 @default.
• W2117148268 cites W1988403143 @default.
• W2117148268 cites W1994014733 @default.
• W2117148268 cites W1995537385 @default.
• W2117148268 cites W1995855518 @default.
• W2117148268 cites W1997466868 @default.
• W2117148268 cites W1997864000 @default.
• W2117148268 cites W2003140374 @default.
• W2117148268 cites W2004854705 @default.
• W2117148268 cites W2004889562 @default.
• W2117148268 cites W2009029293 @default.
• W2117148268 cites W2021585018 @default.
• W2117148268 cites W2023242764 @default.
• W2117148268 cites W2043020487 @default.
• W2117148268 cites W2046966824 @default.
• W2117148268 cites W2052080839 @default.
• W2117148268 cites W2060100969 @default.
• W2117148268 cites W2062594120 @default.
• W2117148268 cites W2066043796 @default.
• W2117148268 cites W2070160483 @default.
• W2117148268 cites W2071377317 @default.
• W2117148268 cites W2072238317 @default.
• W2117148268 cites W2079822284 @default.
• W2117148268 cites W2100744265 @default.
• W2117148268 cites W2101722224 @default.
• W2117148268 cites W2102181946 @default.
• W2117148268 cites W2104042607 @default.
• W2117148268 cites W2108145145 @default.
• W2117148268 cites W2112911107 @default.
• W2117148268 cites W2118190746 @default.
• W2117148268 cites W2121822802 @default.
• W2117148268 cites W2124852194 @default.
• W2117148268 cites W2125324590 @default.
• W2117148268 cites W2128743935 @default.
• W2117148268 cites W2142274635 @default.
• W2117148268 cites W2149828949 @default.
• W2117148268 cites W2156749893 @default.
• W2117148268 cites W2169321777 @default.
• W2117148268 cites W2171894342 @default.
• W2117148268 cites W2187176375 @default.
• W2117148268 cites W2190010290 @default.
• W2117148268 cites W2203250753 @default.
• W2117148268 cites W2228760040 @default.
• W2117148268 cites W2409238223 @default.
• W2117148268 cites W79873509 @default.
• W2117148268 doi "https://doi.org/10.1152/ajpcell.00413.2010" @default.
• W2117148268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174571" @default.
• W2117148268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21653901" @default.
• W2117148268 hasPublicationYear "2011" @default.
• W2117148268 type Work @default.
• W2117148268 sameAs 2117148268 @default.
• W2117148268 citedByCount "20" @default.
• W2117148268 countsByYear W21171482682012 @default.
• W2117148268 countsByYear W21171482682013 @default.
• W2117148268 countsByYear W21171482682014 @default.
• W2117148268 countsByYear W21171482682015 @default.
• W2117148268 countsByYear W21171482682016 @default.
• W2117148268 countsByYear W21171482682017 @default.
• W2117148268 countsByYear W21171482682018 @default.
• W2117148268 countsByYear W21171482682021 @default.
• W2117148268 countsByYear W21171482682023 @default.
• W2117148268 crossrefType "journal-article" @default.
• W2117148268 hasAuthorship W2117148268A5002432241 @default.
• W2117148268 hasAuthorship W2117148268A5017373558 @default.
• W2117148268 hasAuthorship W2117148268A5025177747 @default.
• W2117148268 hasAuthorship W2117148268A5032544743 @default.
• W2117148268 hasAuthorship W2117148268A5037219635 @default.
• W2117148268 hasAuthorship W2117148268A5045441347 @default.
• W2117148268 hasAuthorship W2117148268A5064377405 @default.
• W2117148268 hasAuthorship W2117148268A5065145602 @default.
• W2117148268 hasAuthorship W2117148268A5082259652 @default.

• next