Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117155268> ?p ?o ?g. }
- W2117155268 endingPage "2404" @default.
- W2117155268 startingPage "2392" @default.
- W2117155268 abstract "Macroautophagy is a degradation/recycling system ubiquitous in eukariotic cells, which generates nutrients during fasting under the control of amino acids and hormones, and contributes to the turnover and rejuvenation of cellular components (long-lived proteins, cytomembranes and organelles). Tight coupling between these two functions may be the weak point in cell housekeeping. Ageing denotes a post-maturational deterioration of tissues and organs with the passage of time, due to the progressive accumulation of the misfunctioning cell components because of oxidative damage and an age-dependent decline of turnover rate and housekeeping. Caloric restriction (CR) and lower insulin levels may slow down many age-dependent processes and extend lifespan. Recent evidence is reviewed showing that autophagy is involved in ageing and in the anti-ageing action of anti-ageing calorie restriction: function of autophagy declines during adulthood and is almost negligible at older age; CR prevents the age-dependent decline of autophagic proteolysis and improves the sensitivity of liver cells to stimulation of lysosomal degradation; protection of autophagic proteolysis from the age-related decline co-varies with the duration and level of anti-ageing food restriction like the effects of CR extending lifespan; the pharmacological stimulation of macroautophagy has anti-ageing effects. Besides the involvement in ageing, macroautophagy may have an essential role in the pathogenesis of many age-associated diseases. Higher protein turnover may not fully account for the anti-ageing effects of macroautophagy, and effects of macroautophagy on housekeeping of the cell organelles, antioxidant machinery of cell membranes and transmembrane cell signaling should also be considered." @default.
- W2117155268 created "2016-06-24" @default.
- W2117155268 creator A5021871981 @default.
- W2117155268 creator A5031107244 @default.
- W2117155268 creator A5043124333 @default.
- W2117155268 creator A5048428972 @default.
- W2117155268 date "2004-12-01" @default.
- W2117155268 modified "2023-10-05" @default.
- W2117155268 title "The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases" @default.
- W2117155268 cites W1482715126 @default.
- W2117155268 cites W149130878 @default.
- W2117155268 cites W1559060186 @default.
- W2117155268 cites W1561727665 @default.
- W2117155268 cites W1601027696 @default.
- W2117155268 cites W1620862744 @default.
- W2117155268 cites W1648785664 @default.
- W2117155268 cites W1681758390 @default.
- W2117155268 cites W1751574485 @default.
- W2117155268 cites W1769741450 @default.
- W2117155268 cites W1799882795 @default.
- W2117155268 cites W183550044 @default.
- W2117155268 cites W193269387 @default.
- W2117155268 cites W1955901897 @default.
- W2117155268 cites W1965151763 @default.
- W2117155268 cites W1966317197 @default.
- W2117155268 cites W1968568980 @default.
- W2117155268 cites W1979931199 @default.
- W2117155268 cites W1981917773 @default.
- W2117155268 cites W1982917530 @default.
- W2117155268 cites W1985425785 @default.
- W2117155268 cites W1986119684 @default.
- W2117155268 cites W1988757966 @default.
- W2117155268 cites W1989822993 @default.
- W2117155268 cites W1991914994 @default.
- W2117155268 cites W1993486485 @default.
- W2117155268 cites W1993617172 @default.
- W2117155268 cites W1999232986 @default.
- W2117155268 cites W1999894132 @default.
- W2117155268 cites W2000622138 @default.
- W2117155268 cites W2003985793 @default.
- W2117155268 cites W2006232414 @default.
- W2117155268 cites W2007786714 @default.
- W2117155268 cites W2008482148 @default.
- W2117155268 cites W2011482325 @default.
- W2117155268 cites W2013327472 @default.
- W2117155268 cites W2014717126 @default.
- W2117155268 cites W2019699711 @default.
- W2117155268 cites W2023393277 @default.
- W2117155268 cites W2025933441 @default.
- W2117155268 cites W2027082110 @default.
- W2117155268 cites W2029030037 @default.
- W2117155268 cites W2030679612 @default.
- W2117155268 cites W2040335641 @default.
- W2117155268 cites W2041218417 @default.
- W2117155268 cites W2041679806 @default.
- W2117155268 cites W2043158494 @default.
- W2117155268 cites W2045927301 @default.
- W2117155268 cites W2052722944 @default.
- W2117155268 cites W2053247751 @default.
- W2117155268 cites W2056200690 @default.
- W2117155268 cites W2060544476 @default.
- W2117155268 cites W2063098376 @default.
- W2117155268 cites W2065440747 @default.
- W2117155268 cites W2066519654 @default.
- W2117155268 cites W2066727453 @default.
- W2117155268 cites W2067402381 @default.
- W2117155268 cites W2069988949 @default.
- W2117155268 cites W2072310161 @default.
- W2117155268 cites W2072670607 @default.
- W2117155268 cites W2075548234 @default.
- W2117155268 cites W2076248484 @default.
- W2117155268 cites W2086434878 @default.
- W2117155268 cites W2087467174 @default.
- W2117155268 cites W2095282336 @default.
- W2117155268 cites W2096794529 @default.
- W2117155268 cites W2100482385 @default.
- W2117155268 cites W2105637710 @default.
- W2117155268 cites W2106043356 @default.
- W2117155268 cites W2106277266 @default.
- W2117155268 cites W2108086395 @default.
- W2117155268 cites W2115596765 @default.
- W2117155268 cites W2115956491 @default.
- W2117155268 cites W2116946811 @default.
- W2117155268 cites W2119360937 @default.
- W2117155268 cites W2125840439 @default.
- W2117155268 cites W2126100394 @default.
- W2117155268 cites W2131150217 @default.
- W2117155268 cites W2131591599 @default.
- W2117155268 cites W2133732190 @default.
- W2117155268 cites W2143358143 @default.
- W2117155268 cites W2143730031 @default.
- W2117155268 cites W2148133449 @default.
- W2117155268 cites W2149388099 @default.
- W2117155268 cites W2149983895 @default.
- W2117155268 cites W2153725686 @default.
- W2117155268 cites W2158303258 @default.
- W2117155268 cites W2158979163 @default.
- W2117155268 cites W2160348999 @default.