FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117165138> ?p ?o ?g. }

• W2117165138 endingPage "E1364" @default.
• W2117165138 startingPage "E1359" @default.
• W2117165138 abstract "In enterocytes, glutamine serves as the major source of energy; another metabolic fate of glutamine is conversion to citrulline. Because sepsis can affect gut function and integrity, alterations in glutamine metabolism may exist and lead to decreased citrulline production. This study aimed to investigate how sepsis affects glutamine metabolism, including its conversion to citrulline, by measuring glutamine and citrulline flux, fractional splanchnic extraction of glutamine and leucine, and the contribution of glutamine nitrogen to citrulline in septic patients and healthy controls. Eight patients with severe sepsis and 10 healthy controls were given primed, constant intravenous infusion of [(2)H2]citrulline and sequential administration of intravenous and enteral [α-(15)N]glutamine and [(13)C]leucine in the postabsorptive state. The results showed that, compared with healthy controls, septic patients had a significantly lower whole body citrulline flux and plasma concentration, higher endogenous leucine flux, and higher glutamine clearance. Fractional splanchnic extraction of leucine was higher in septic patients than in controls, but fractional extraction of glutamine was not different. The majority of the (15)N label transferred from glutamine to citrulline was found at the α-position. These results demonstrate that lower glutamine plasma concentrations in sepsis were a result of increased glutamine clearance. Despite adequate splanchnic uptake of glutamine, there is decreased production of citrulline, suggesting a defect in the metabolic conversion of glutamine to citrulline, decreased uptake of glutamine by the enterocyte but increased uptake by the liver, and/or shunting of glutamine to other metabolic pathways." @default.
• W2117165138 created "2016-06-24" @default.
• W2117165138 creator A5008350505 @default.
• W2117165138 creator A5012794414 @default.
• W2117165138 creator A5068674673 @default.
• W2117165138 creator A5072570218 @default.
• W2117165138 date "2013-06-15" @default.
• W2117165138 modified "2023-10-16" @default.
• W2117165138 title "Alterations in glutamine metabolism and its conversion to citrulline in sepsis" @default.
• W2117165138 cites W125289779 @default.
• W2117165138 cites W1479784763 @default.
• W2117165138 cites W1519365472 @default.
• W2117165138 cites W1754402125 @default.
• W2117165138 cites W1877864798 @default.
• W2117165138 cites W1935064934 @default.
• W2117165138 cites W1973817122 @default.
• W2117165138 cites W1975856152 @default.
• W2117165138 cites W1982163811 @default.
• W2117165138 cites W1982347002 @default.
• W2117165138 cites W1984662779 @default.
• W2117165138 cites W1984990706 @default.
• W2117165138 cites W1988269268 @default.
• W2117165138 cites W1997409959 @default.
• W2117165138 cites W2002008524 @default.
• W2117165138 cites W2004003158 @default.
• W2117165138 cites W2014644469 @default.
• W2117165138 cites W2026788098 @default.
• W2117165138 cites W2030419714 @default.
• W2117165138 cites W2036747686 @default.
• W2117165138 cites W2037524548 @default.
• W2117165138 cites W2045713536 @default.
• W2117165138 cites W2054341520 @default.
• W2117165138 cites W2076034255 @default.
• W2117165138 cites W2087203965 @default.
• W2117165138 cites W2091216356 @default.
• W2117165138 cites W2103004159 @default.
• W2117165138 cites W2106842732 @default.
• W2117165138 cites W2127373470 @default.
• W2117165138 cites W2132235643 @default.
• W2117165138 cites W2142289111 @default.
• W2117165138 cites W2147222575 @default.
• W2117165138 cites W2151684157 @default.
• W2117165138 cites W2187033016 @default.
• W2117165138 cites W2276322181 @default.
• W2117165138 cites W2283166824 @default.
• W2117165138 cites W2397829668 @default.
• W2117165138 cites W2400782206 @default.
• W2117165138 cites W97871616 @default.
• W2117165138 doi "https://doi.org/10.1152/ajpendo.00628.2012" @default.
• W2117165138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680701" @default.
• W2117165138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23612995" @default.
• W2117165138 hasPublicationYear "2013" @default.
• W2117165138 type Work @default.
• W2117165138 sameAs 2117165138 @default.
• W2117165138 citedByCount "50" @default.
• W2117165138 countsByYear W21171651382013 @default.
• W2117165138 countsByYear W21171651382014 @default.
• W2117165138 countsByYear W21171651382015 @default.
• W2117165138 countsByYear W21171651382016 @default.
• W2117165138 countsByYear W21171651382017 @default.
• W2117165138 countsByYear W21171651382018 @default.
• W2117165138 countsByYear W21171651382019 @default.
• W2117165138 countsByYear W21171651382020 @default.
• W2117165138 countsByYear W21171651382021 @default.
• W2117165138 countsByYear W21171651382022 @default.
• W2117165138 countsByYear W21171651382023 @default.
• W2117165138 crossrefType "journal-article" @default.
• W2117165138 hasAuthorship W2117165138A5008350505 @default.
• W2117165138 hasAuthorship W2117165138A5012794414 @default.
• W2117165138 hasAuthorship W2117165138A5068674673 @default.
• W2117165138 hasAuthorship W2117165138A5072570218 @default.
• W2117165138 hasBestOaLocation W21171651382 @default.
• W2117165138 hasConcept C126322002 @default.
• W2117165138 hasConcept C134018914 @default.
• W2117165138 hasConcept C158846371 @default.
• W2117165138 hasConcept C185592680 @default.
• W2117165138 hasConcept C2775849017 @default.
• W2117165138 hasConcept C2776580952 @default.
• W2117165138 hasConcept C2777468819 @default.
• W2117165138 hasConcept C2778384902 @default.
• W2117165138 hasConcept C2779129087 @default.
• W2117165138 hasConcept C2779349466 @default.
• W2117165138 hasConcept C515207424 @default.
• W2117165138 hasConcept C55493867 @default.
• W2117165138 hasConcept C62231903 @default.
• W2117165138 hasConcept C71924100 @default.
• W2117165138 hasConcept C86803240 @default.
• W2117165138 hasConceptScore W2117165138C126322002 @default.
• W2117165138 hasConceptScore W2117165138C134018914 @default.
• W2117165138 hasConceptScore W2117165138C158846371 @default.
• W2117165138 hasConceptScore W2117165138C185592680 @default.
• W2117165138 hasConceptScore W2117165138C2775849017 @default.
• W2117165138 hasConceptScore W2117165138C2776580952 @default.
• W2117165138 hasConceptScore W2117165138C2777468819 @default.
• W2117165138 hasConceptScore W2117165138C2778384902 @default.
• W2117165138 hasConceptScore W2117165138C2779129087 @default.
• W2117165138 hasConceptScore W2117165138C2779349466 @default.
• W2117165138 hasConceptScore W2117165138C515207424 @default.

• next