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- W2117177423 abstract "Introduction: Within recent years, glucagon-like peptide 1 receptor agonists (GLP-1-RA) have emerged as a new treatment option for type 2 diabetes. The GLP-1-RA are administered subcutaneously and differ substantially in pharmacokinetic profiles. Areas covered: This review describes the pharmacokinetics and safety aspects of the currently available GLP-1 receptor agonists, liraglutide (based on the structure of native GLP-1), exenatide twice daily and exenatide once weekly (based on exendin-4) in relation to the kinetics and toxicology of native GLP-1. The review is based on electronic literature searches and legal documents in the form of assessment reports from the European Medicines Agency and the United States Food and Drug Administration. Expert opinion: GLP-1-based therapy combines several unique mechanisms of action and have the potential to gain widespread use in the fight against diabetes and obesity. The difference in chemical structure have strong implications for key pharmacokinetic parameters such as absorption and clearance, and eventually the safety and efficacy of the individual GLP-1-RA. The main safety concerns are pancreatitis and neoplasms, for which there are no identifiable differences in risk between the available agents. Antibody formation and injection site reactions are more frequent with the exendin-4-based compounds. The efficacy with regard to HbA1c reduction is superior with the longer-acting agonists, whereas the shorter-acting GLP-1-RA seems to provide greater postprandial glucose control and lower tolerability as a possible consequence of less induction of tachyphylaxis. The future place of these agents will depend on the added safety and efficacy data in the several ongoing cardiovascular outcome trials." @default.
- W2117177423 created "2016-06-24" @default.
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- W2117177423 creator A5051382562 @default.
- W2117177423 creator A5079352451 @default.
- W2117177423 date "2012-10-24" @default.
- W2117177423 modified "2023-10-15" @default.
- W2117177423 title "GLP-1 agonists for type 2 diabetes: pharmacokinetic and toxicological considerations" @default.
- W2117177423 cites W108475790 @default.
- W2117177423 cites W1483014275 @default.
- W2117177423 cites W1508573927 @default.
- W2117177423 cites W1555131529 @default.
- W2117177423 cites W1572696163 @default.
- W2117177423 cites W1910418518 @default.
- W2117177423 cites W1969856989 @default.
- W2117177423 cites W1973109904 @default.
- W2117177423 cites W1975591028 @default.
- W2117177423 cites W1976367840 @default.
- W2117177423 cites W1978297909 @default.
- W2117177423 cites W1978953702 @default.
- W2117177423 cites W1984430136 @default.
- W2117177423 cites W198655243 @default.
- W2117177423 cites W1994320162 @default.
- W2117177423 cites W1996669620 @default.
- W2117177423 cites W2001097346 @default.
- W2117177423 cites W2001592873 @default.
- W2117177423 cites W2003444892 @default.
- W2117177423 cites W2004409542 @default.
- W2117177423 cites W2007910256 @default.
- W2117177423 cites W2008132861 @default.
- W2117177423 cites W2009448348 @default.
- W2117177423 cites W2013851956 @default.
- W2117177423 cites W2019252344 @default.
- W2117177423 cites W2020787870 @default.
- W2117177423 cites W2025237740 @default.
- W2117177423 cites W2031468509 @default.
- W2117177423 cites W2032264656 @default.
- W2117177423 cites W2057913111 @default.
- W2117177423 cites W2062027317 @default.
- W2117177423 cites W2063715420 @default.
- W2117177423 cites W2065045192 @default.
- W2117177423 cites W2070027753 @default.
- W2117177423 cites W2071835038 @default.
- W2117177423 cites W2072494899 @default.
- W2117177423 cites W2073936282 @default.
- W2117177423 cites W2079355745 @default.
- W2117177423 cites W2081271380 @default.
- W2117177423 cites W2082032596 @default.
- W2117177423 cites W2084534846 @default.
- W2117177423 cites W2086177834 @default.
- W2117177423 cites W2089304685 @default.
- W2117177423 cites W2098459806 @default.
- W2117177423 cites W2105726125 @default.
- W2117177423 cites W2105812875 @default.
- W2117177423 cites W2106036385 @default.
- W2117177423 cites W2106824929 @default.
- W2117177423 cites W2107949845 @default.
- W2117177423 cites W2112981414 @default.
- W2117177423 cites W2115357902 @default.
- W2117177423 cites W2118710260 @default.
- W2117177423 cites W2122696108 @default.
- W2117177423 cites W2130478319 @default.
- W2117177423 cites W2133533488 @default.
- W2117177423 cites W2133588331 @default.
- W2117177423 cites W2135854640 @default.
- W2117177423 cites W2136254957 @default.
- W2117177423 cites W2137352234 @default.
- W2117177423 cites W2137805490 @default.
- W2117177423 cites W2138077952 @default.
- W2117177423 cites W2138290933 @default.
- W2117177423 cites W2138897693 @default.
- W2117177423 cites W2140536043 @default.
- W2117177423 cites W2140682563 @default.
- W2117177423 cites W2140978079 @default.
- W2117177423 cites W2142903571 @default.
- W2117177423 cites W2143014102 @default.
- W2117177423 cites W2150137315 @default.
- W2117177423 cites W2150614212 @default.
- W2117177423 cites W2158778171 @default.
- W2117177423 cites W2160001758 @default.
- W2117177423 cites W2160945140 @default.
- W2117177423 cites W2162001095 @default.
- W2117177423 cites W2164535707 @default.
- W2117177423 cites W2164738160 @default.
- W2117177423 cites W2164961795 @default.
- W2117177423 cites W2170606300 @default.
- W2117177423 cites W2344620176 @default.
- W2117177423 cites W4234825176 @default.
- W2117177423 doi "https://doi.org/10.1517/17425255.2013.731394" @default.
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- W2117177423 hasPublicationYear "2012" @default.
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