FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117214469> ?p ?o ?g. }

• W2117214469 abstract "The pharmacokinetics and biodistribution of vinorelbine (VRB) delivered in a parenteral lipid emulsion (VLE) were evaluated, and compared with that of a commercial vinorelbine injectable solution (Navelbine ® i.v., VS). After intravenous administration to rats at doses of 2.25, 4.5, and 9 mg/kg, the AUC 0―24 h was significantly different (1.15 ± 0.27, 2.65 ± 0.82, and 8.18 ± 1.10 mg/L/h for 2.25, 4.5, and 9 mg/kg, respectively), other pharmacokinetic parameters of VLE, such as the Cmax, CL, and Vss, were also dependent on the dose of VLE. The pharmacokinetics of VLE in rats was dose-dependent in the dosage range of 2.25-9 mg/kg. VLE exhibited significantly higher VRB concentration than that of VS at the initial time points, it also produced a higher AUC 0―24 h , MRT and lower CL in comparison with VS. In beagle dogs, VLE exhibited pharmacokinetic bioequivalence to VS. The tissue distribution in mice of VLE was modified compared to VS, the AUC 0―48 h of VLE was grater in the liver, spleen, kidney and small intestine, but a little lower in the heart and lung. Practical applications: To reduce the severe local venous irritation of vinorelbine (VRB) at the aim of improve patient compliance, a parenteral vinorelbine loaded lipid emulsion (VLE) has been developed, and then systematical preclinical evaluations have been done. The pharmacokinetics and tissue distribution study reported here are part of the preclinical evaluation. VLE exhibited non-linear relationship between dose and AUC 0―24 h after single intravenous dose (at doses of 2.25, 4.5, and 9 mg/kg) to rats. Pharmacokinetic bioequivalence between VLE and VS was found after single intravenous infusion administration a dose of 1.33 mg/kg to beagle dogs. Tissue distribution results showed that the AUC 0―48 h of VLE was grater in the liver, spleen, kidney, and small intestine, but a little lower in the heart and lung. These results could provide information for the further pharmacodynamics and pharmacology study, and finally for clinical use of VLE." @default.
• W2117214469 created "2016-06-24" @default.
• W2117214469 creator A5003761894 @default.
• W2117214469 creator A5012773578 @default.
• W2117214469 creator A5026093502 @default.
• W2117214469 creator A5050080798 @default.
• W2117214469 creator A5065650359 @default.
• W2117214469 creator A5070273499 @default.
• W2117214469 creator A5080170196 @default.
• W2117214469 date "2011-01-20" @default.
• W2117214469 modified "2023-09-22" @default.
• W2117214469 title "Pharmacokinetics and tissue distribution of vinorelbine delivered in parenteral lipid emulsion" @default.
• W2117214469 cites W1241822319 @default.
• W2117214469 cites W1964961780 @default.
• W2117214469 cites W1974503306 @default.
• W2117214469 cites W1978965935 @default.
• W2117214469 cites W1979298161 @default.
• W2117214469 cites W1991186657 @default.
• W2117214469 cites W2008407628 @default.
• W2117214469 cites W2010335440 @default.
• W2117214469 cites W2010582425 @default.
• W2117214469 cites W2016870138 @default.
• W2117214469 cites W2026881910 @default.
• W2117214469 cites W2033715508 @default.
• W2117214469 cites W2036634828 @default.
• W2117214469 cites W2053991217 @default.
• W2117214469 cites W2054498830 @default.
• W2117214469 cites W2065522282 @default.
• W2117214469 cites W2085271326 @default.
• W2117214469 cites W2089298436 @default.
• W2117214469 cites W2093709044 @default.
• W2117214469 cites W2095436633 @default.
• W2117214469 cites W2095691210 @default.
• W2117214469 cites W2106141025 @default.
• W2117214469 cites W2121762824 @default.
• W2117214469 cites W2123174763 @default.
• W2117214469 cites W2147839112 @default.
• W2117214469 doi "https://doi.org/10.1002/ejlt.201000433" @default.
• W2117214469 hasPublicationYear "2011" @default.
• W2117214469 type Work @default.
• W2117214469 sameAs 2117214469 @default.
• W2117214469 citedByCount "1" @default.
• W2117214469 countsByYear W21172144692021 @default.
• W2117214469 crossrefType "journal-article" @default.
• W2117214469 hasAuthorship W2117214469A5003761894 @default.
• W2117214469 hasAuthorship W2117214469A5012773578 @default.
• W2117214469 hasAuthorship W2117214469A5026093502 @default.
• W2117214469 hasAuthorship W2117214469A5050080798 @default.
• W2117214469 hasAuthorship W2117214469A5065650359 @default.
• W2117214469 hasAuthorship W2117214469A5070273499 @default.
• W2117214469 hasAuthorship W2117214469A5080170196 @default.
• W2117214469 hasConcept C110121322 @default.
• W2117214469 hasConcept C112705442 @default.
• W2117214469 hasConcept C126322002 @default.
• W2117214469 hasConcept C134306372 @default.
• W2117214469 hasConcept C139254425 @default.
• W2117214469 hasConcept C185592680 @default.
• W2117214469 hasConcept C202751555 @default.
• W2117214469 hasConcept C22979827 @default.
• W2117214469 hasConcept C2776694085 @default.
• W2117214469 hasConcept C2776820430 @default.
• W2117214469 hasConcept C2777807558 @default.
• W2117214469 hasConcept C2778239845 @default.
• W2117214469 hasConcept C2780350996 @default.
• W2117214469 hasConcept C33923547 @default.
• W2117214469 hasConcept C42404028 @default.
• W2117214469 hasConcept C55493867 @default.
• W2117214469 hasConcept C71924100 @default.
• W2117214469 hasConcept C98274493 @default.
• W2117214469 hasConceptScore W2117214469C110121322 @default.
• W2117214469 hasConceptScore W2117214469C112705442 @default.
• W2117214469 hasConceptScore W2117214469C126322002 @default.
• W2117214469 hasConceptScore W2117214469C134306372 @default.
• W2117214469 hasConceptScore W2117214469C139254425 @default.
• W2117214469 hasConceptScore W2117214469C185592680 @default.
• W2117214469 hasConceptScore W2117214469C202751555 @default.
• W2117214469 hasConceptScore W2117214469C22979827 @default.
• W2117214469 hasConceptScore W2117214469C2776694085 @default.
• W2117214469 hasConceptScore W2117214469C2776820430 @default.
• W2117214469 hasConceptScore W2117214469C2777807558 @default.
• W2117214469 hasConceptScore W2117214469C2778239845 @default.
• W2117214469 hasConceptScore W2117214469C2780350996 @default.
• W2117214469 hasConceptScore W2117214469C33923547 @default.
• W2117214469 hasConceptScore W2117214469C42404028 @default.
• W2117214469 hasConceptScore W2117214469C55493867 @default.
• W2117214469 hasConceptScore W2117214469C71924100 @default.
• W2117214469 hasConceptScore W2117214469C98274493 @default.
• W2117214469 hasLocation W21172144691 @default.
• W2117214469 hasOpenAccess W2117214469 @default.
• W2117214469 hasPrimaryLocation W21172144691 @default.
• W2117214469 hasRelatedWork W1973975100 @default.
• W2117214469 hasRelatedWork W2046878103 @default.
• W2117214469 hasRelatedWork W2313383703 @default.
• W2117214469 hasRelatedWork W2313886632 @default.
• W2117214469 hasRelatedWork W2346694037 @default.
• W2117214469 hasRelatedWork W2374859151 @default.
• W2117214469 hasRelatedWork W2407895153 @default.
• W2117214469 hasRelatedWork W2409410491 @default.
• W2117214469 hasRelatedWork W2490938122 @default.
• W2117214469 hasRelatedWork W2726895853 @default.

• next