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• W2117217496 abstract "Wahaidi VY, Kowolik MJ, Eckert GJ, Galli DM: Endotoxemia and the host systemic response during experimental gingivitis. J Clin Periodontol 2011; 38: 412–417. doi: 10.1111/j.1600-051X.2011.01710.x. Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p<0.05). In the endotoxin-negative group this increase was associated with the black subjects whereas in the endotoxin-positive group change in neutrophil activity was driven by the female subpopulation. Serum cytokines, CRP, and fibrinogen levels did not change during the study. Conclusions: Experimental gingivitis was associated with endotoxemia and hyperactivity of circulating neutrophils, but not with changes in systemic levels of cytokines and acute-phase proteins. This may be attributed to the mild nature and the short duration of the induced gingivitis." @default.
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• W2117217496 date "2011-02-14" @default.
• W2117217496 modified "2023-10-14" @default.
• W2117217496 title "Endotoxemia and the host systemic response during experimental gingivitis" @default.
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• W2117217496 doi "https://doi.org/10.1111/j.1600-051x.2011.01710.x" @default.
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