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- W2117223640 abstract "OBJECTIVE Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The aim of the study was to evaluate clinical data of IPF patients listed for LTX and to investigate survival outcomes after LTX with respect to single (SLT) and bilateral lung transplantation (BLT). METHODS Data were retrospectively collected from September 1989 until July 2011 of all IPF patients registered for lung transplantation in the Netherlands. Patients were included after revision of the diagnosis based on the IPF criteria set by the ATS/ERS/JRS/ALAT. Clinical data during LTX traject and donor data were collected. RESULTS 98 IPF patients were listed for LTX. During the waiting list period 30% of the patients died. Mean pulmonary artery pressure, six-minute walking distance and the use of supplemental oxygen were significant predictors of mortality on the waiting list. 52 IPF patients received LTX with a median overall survival after LTX of 10 years. BLT had a significant survival advantage compared to SLT (respective median survival of >120 months and 67 months; p = 0.023). CONCLUSION Waiting list mortality in IPF patients appeared to be high (30%). This study revealed a median survival of 10 years after LTX in IPF. Furthermore, our study demonstrated significant survival advantage of BLT compared to SLT in a well-characterized group of IPF patients." @default.
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- W2117223640 date "2013-09-01" @default.
- W2117223640 modified "2023-09-28" @default.
- W2117223640 title "Better survival outcomes after bilateral lung transplantation compared to single lung transplantation in patients with idiopathic pulmonary fibrosis" @default.
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