FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117231490> ?p ?o ?g. }

• W2117231490 endingPage "34" @default.
• W2117231490 startingPage "21" @default.
• W2117231490 abstract "In the crystal structure of human T-state hemoglobin with a sebacyl residue cross-linking the two beta-subunit Lys82,s (DecHb), the Fe atoms of the alpha-subunit hemes are found to be oxidized with a water molecule bound. The three-dimensional structure and heme geometries were compared to those of deoxyhemoglobin and other partially and fully oxidized hemoglobins [R. Liddington, Z. Derewenda, E. Dodson, R. Hubbard, G. Dodson, J. Mol. Biol. 228 (1992) 551]. The heme geometries of the alpha-subunits are consistent with those observed in oxidized structures. The proximal histidines of the alpha-subunits move toward the heme plane shifting the F-helix and FG-corner in a manner observed for partially oxidized human hemoglobin. This supports the hypothesis that these perturbations may precede the T- to R-state transition. Circular dichroism studies comparing DecHb and natural human hemoglobin in the deoxy and CO ligated forms confirm that the conformations of the deoxy forms are identical, but the ligated forms have slight differences in the solution structures. DecHb is found to be more resistant to autoxidation than natural hemoglobin. The time course of autoxidation of DecHb shows that it is virtually absent for the first 1500 min followed by a rapid increase. Thus, the discovery of the oxidation of the alpha-subunits in the deoxy-crystals is quite unexpected. The data confirm that ligation of the alpha-subunits precedes that of the beta-subunits. This may suggest a low ligand affinity of the alpha-diligated form of hemoglobin." @default.
• W2117231490 created "2016-06-24" @default.
• W2117231490 creator A5010242514 @default.
• W2117231490 creator A5010327441 @default.
• W2117231490 creator A5019176442 @default.
• W2117231490 creator A5049422690 @default.
• W2117231490 creator A5066462558 @default.
• W2117231490 creator A5069231811 @default.
• W2117231490 creator A5075212807 @default.
• W2117231490 creator A5060911450 @default.
• W2117231490 date "1998-01-01" @default.
• W2117231490 modified "2023-10-17" @default.
• W2117231490 title "α-Subunit oxidation in T-state crystals of a sebacyl cross-linked human hemoglobin with unusual autoxidation properties" @default.
• W2117231490 cites W1494977501 @default.
• W2117231490 cites W1546234696 @default.
• W2117231490 cites W1598451418 @default.
• W2117231490 cites W1608052268 @default.
• W2117231490 cites W1842320575 @default.
• W2117231490 cites W1901470441 @default.
• W2117231490 cites W1910226981 @default.
• W2117231490 cites W1966041739 @default.
• W2117231490 cites W1973154476 @default.
• W2117231490 cites W1973978931 @default.
• W2117231490 cites W1983400172 @default.
• W2117231490 cites W1986243805 @default.
• W2117231490 cites W1987963632 @default.
• W2117231490 cites W1990668541 @default.
• W2117231490 cites W2002448910 @default.
• W2117231490 cites W2013014735 @default.
• W2117231490 cites W2013083986 @default.
• W2117231490 cites W2027643131 @default.
• W2117231490 cites W2029235042 @default.
• W2117231490 cites W2037365817 @default.
• W2117231490 cites W2037649796 @default.
• W2117231490 cites W2038179420 @default.
• W2117231490 cites W2044375512 @default.
• W2117231490 cites W2046643040 @default.
• W2117231490 cites W2058238738 @default.
• W2117231490 cites W2066459154 @default.
• W2117231490 cites W2073198049 @default.
• W2117231490 cites W2074376299 @default.
• W2117231490 cites W2081502357 @default.
• W2117231490 cites W2088437224 @default.
• W2117231490 cites W2132397429 @default.
• W2117231490 cites W2160149634 @default.
• W2117231490 doi "https://doi.org/10.1016/s0301-4622(97)00096-3" @default.
• W2117231490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9474760" @default.
• W2117231490 hasPublicationYear "1998" @default.
• W2117231490 type Work @default.
• W2117231490 sameAs 2117231490 @default.
• W2117231490 citedByCount "10" @default.
• W2117231490 countsByYear W21172314902012 @default.
• W2117231490 crossrefType "journal-article" @default.
• W2117231490 hasAuthorship W2117231490A5010242514 @default.
• W2117231490 hasAuthorship W2117231490A5010327441 @default.
• W2117231490 hasAuthorship W2117231490A5019176442 @default.
• W2117231490 hasAuthorship W2117231490A5049422690 @default.
• W2117231490 hasAuthorship W2117231490A5060911450 @default.
• W2117231490 hasAuthorship W2117231490A5066462558 @default.
• W2117231490 hasAuthorship W2117231490A5069231811 @default.
• W2117231490 hasAuthorship W2117231490A5075212807 @default.
• W2117231490 hasConcept C104292427 @default.
• W2117231490 hasConcept C104317684 @default.
• W2117231490 hasConcept C115624301 @default.
• W2117231490 hasConcept C133571119 @default.
• W2117231490 hasConcept C178790620 @default.
• W2117231490 hasConcept C181199279 @default.
• W2117231490 hasConcept C185592680 @default.
• W2117231490 hasConcept C20705724 @default.
• W2117231490 hasConcept C2776217839 @default.
• W2117231490 hasConcept C2777393523 @default.
• W2117231490 hasConcept C2778917026 @default.
• W2117231490 hasConcept C32909587 @default.
• W2117231490 hasConcept C37329643 @default.
• W2117231490 hasConcept C55493867 @default.
• W2117231490 hasConcept C71240020 @default.
• W2117231490 hasConcept C8010536 @default.
• W2117231490 hasConceptScore W2117231490C104292427 @default.
• W2117231490 hasConceptScore W2117231490C104317684 @default.
• W2117231490 hasConceptScore W2117231490C115624301 @default.
• W2117231490 hasConceptScore W2117231490C133571119 @default.
• W2117231490 hasConceptScore W2117231490C178790620 @default.
• W2117231490 hasConceptScore W2117231490C181199279 @default.
• W2117231490 hasConceptScore W2117231490C185592680 @default.
• W2117231490 hasConceptScore W2117231490C20705724 @default.
• W2117231490 hasConceptScore W2117231490C2776217839 @default.
• W2117231490 hasConceptScore W2117231490C2777393523 @default.
• W2117231490 hasConceptScore W2117231490C2778917026 @default.
• W2117231490 hasConceptScore W2117231490C32909587 @default.
• W2117231490 hasConceptScore W2117231490C37329643 @default.
• W2117231490 hasConceptScore W2117231490C55493867 @default.
• W2117231490 hasConceptScore W2117231490C71240020 @default.
• W2117231490 hasConceptScore W2117231490C8010536 @default.
• W2117231490 hasIssue "1" @default.
• W2117231490 hasLocation W21172314901 @default.
• W2117231490 hasLocation W21172314902 @default.
• W2117231490 hasOpenAccess W2117231490 @default.
• W2117231490 hasPrimaryLocation W21172314901 @default.

• next