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• W2117234807 abstract "p ulmonary hypertension (PH) is a hemodynamic problem that can result in grave morbidity and mortality including right-sided heart failure and sudden death. The diagnosis of PH is commonly intuited largely because of the lack of sensitivity and specificity of the symptoms and signs at initial examination of the patient. Severe acute PH, when first diagnosed, is often irreversible and associated with a high mortality.a Treatment of this condition is most successful when it is diagnosed early before irreversible damage has occurred to the pulmonary vasculature. The incidence of acute PH is difficult to estimate; however, pulmqnary thromboembolism is the most common cause of acute PH in hospitalized patients. It has been estimated that as many as 15% of all persons admitted to hospitals may have complications of pulmonary embolism. The characteristics of pulmonary circulation and right ventricular (RV) function are intrinsically related to each other and interdependent. Normally, the pulmonary vascular bed offers remarkably little resistance to flow. PH results from reductions in the caliber of the pulmonary vessels and/or increases in pulmonary blood flow. These two conditions can be caused by a series of structural and functional abnormalities in the pulmonary vasculature, the pulmonary parenchyma, or the myocardium. Alteration in factors affecting RV performance directly impact pulmonary blood flow, and vice versa. Recent advances in our understanding of the pathogenesis of PH are providing clues to possible new treatments. However, despite our expanding knowledge, the periopera-" @default.
• W2117234807 created "2016-06-24" @default.
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• W2117234807 date "2001-06-01" @default.
• W2117234807 modified "2023-09-25" @default.
• W2117234807 title "Update: Pulmonary hypertension and right ventricular function, pathophysiology and pharmacological management" @default.
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• W2117234807 doi "https://doi.org/10.1053/sane.2001.25144" @default.
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