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- W2117266418 abstract "This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD).In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus.Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine) that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc) receptors and human leukocyte antigens I and II.Unexpectedly, the extent of innate immune gene upregulation in AD was modest relative to the robust response apparent in the aged brain, consistent with the emerging idea of a critical involvement of inflammation in the earliest stages, perhaps even in the preclinical stage, of AD. Ultimately, our data suggest that an important strategy to maintain cognitive health and resilience involves reducing chronic innate immune activation that should be initiated in late midlife." @default.
- W2117266418 created "2016-06-24" @default.
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- W2117266418 date "2012-07-23" @default.
- W2117266418 modified "2023-10-13" @default.
- W2117266418 title "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study" @default.
- W2117266418 cites W116725893 @default.
- W2117266418 cites W1490802705 @default.
- W2117266418 cites W1565096249 @default.
- W2117266418 cites W1578837987 @default.
- W2117266418 cites W1636974729 @default.
- W2117266418 cites W1678111194 @default.
- W2117266418 cites W1776526278 @default.
- W2117266418 cites W1893620705 @default.
- W2117266418 cites W1935472980 @default.
- W2117266418 cites W1963812982 @default.
- W2117266418 cites W1966971616 @default.
- W2117266418 cites W1967176607 @default.
- W2117266418 cites W1970319404 @default.
- W2117266418 cites W1970606114 @default.
- W2117266418 cites W1971616282 @default.
- W2117266418 cites W1971963029 @default.
- W2117266418 cites W1975154479 @default.
- W2117266418 cites W1976445933 @default.
- W2117266418 cites W1977585036 @default.
- W2117266418 cites W1978472910 @default.
- W2117266418 cites W1979096652 @default.
- W2117266418 cites W1980578362 @default.
- W2117266418 cites W1980940682 @default.
- W2117266418 cites W1985060701 @default.
- W2117266418 cites W1985168009 @default.
- W2117266418 cites W1989208474 @default.
- W2117266418 cites W1991794361 @default.
- W2117266418 cites W1993909442 @default.
- W2117266418 cites W1993993136 @default.
- W2117266418 cites W1996050664 @default.
- W2117266418 cites W1997962428 @default.
- W2117266418 cites W1998981667 @default.
- W2117266418 cites W1999295089 @default.
- W2117266418 cites W2000547390 @default.
- W2117266418 cites W2004773897 @default.
- W2117266418 cites W2011637489 @default.
- W2117266418 cites W2015163544 @default.
- W2117266418 cites W2015851283 @default.
- W2117266418 cites W2023136593 @default.
- W2117266418 cites W2024816116 @default.
- W2117266418 cites W2026303819 @default.
- W2117266418 cites W2029672245 @default.
- W2117266418 cites W2032831023 @default.
- W2117266418 cites W2033987011 @default.
- W2117266418 cites W2037599213 @default.
- W2117266418 cites W2038604581 @default.
- W2117266418 cites W2039749927 @default.
- W2117266418 cites W2040892689 @default.
- W2117266418 cites W2043968692 @default.
- W2117266418 cites W2044975042 @default.
- W2117266418 cites W2047658053 @default.
- W2117266418 cites W2048032544 @default.
- W2117266418 cites W2048400917 @default.
- W2117266418 cites W2052549355 @default.
- W2117266418 cites W2055568011 @default.
- W2117266418 cites W2059568035 @default.
- W2117266418 cites W2061122183 @default.
- W2117266418 cites W2064377810 @default.
- W2117266418 cites W2065330071 @default.
- W2117266418 cites W2066344383 @default.
- W2117266418 cites W2068381032 @default.
- W2117266418 cites W2075901113 @default.
- W2117266418 cites W2076260194 @default.
- W2117266418 cites W2079865579 @default.
- W2117266418 cites W2081655354 @default.
- W2117266418 cites W2085558085 @default.
- W2117266418 cites W2085667648 @default.
- W2117266418 cites W2088695727 @default.
- W2117266418 cites W2090640877 @default.
- W2117266418 cites W2094272888 @default.
- W2117266418 cites W2097599737 @default.
- W2117266418 cites W2099005297 @default.
- W2117266418 cites W2103369019 @default.
- W2117266418 cites W2105197440 @default.
- W2117266418 cites W2105385589 @default.
- W2117266418 cites W2106313529 @default.
- W2117266418 cites W2106914633 @default.
- W2117266418 cites W2108676263 @default.
- W2117266418 cites W2109342780 @default.
- W2117266418 cites W2109972881 @default.
- W2117266418 cites W2113107925 @default.
- W2117266418 cites W2113769407 @default.
- W2117266418 cites W2114926230 @default.
- W2117266418 cites W2116784956 @default.
- W2117266418 cites W2119098586 @default.
- W2117266418 cites W2120704640 @default.
- W2117266418 cites W2122806101 @default.
- W2117266418 cites W2123446167 @default.