Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117269757> ?p ?o ?g. }
- W2117269757 endingPage "330" @default.
- W2117269757 startingPage "319" @default.
- W2117269757 abstract "Cortactin contributes to growth cone morphogenesis by forming with dynamin, ring-shaped complexes that mechanically bundle and stabilise F-actin. However, the regulatory mechanism of cortactin action is poorly understood.Immunofluorescence microscopy revealed that protein kinase C (PKC) α colocalises with cortactin at growth cone filopodia in SH-SY5Y neuroblastoma cells. PKC activation by phorbol 12-myristate 13-acetate causes cortactin phosphorylation, filopodial retraction and F-actin-bundle loss. Moreover, PKCα directly phosphorylates cortactin in vitro at S135/T145/S172, mitigating both cortactin's actin-binding and actin-crosslinking activity, whereas cellular expression of a phosphorylation-mimetic cortactin mutant hinders filopodial formation with a significant decrease of actin bundles.Our results indicate that PKC-mediated cortactin phosphorylation might be implicated in the maintenance of growth cone." @default.
- W2117269757 created "2016-06-24" @default.
- W2117269757 creator A5009297379 @default.
- W2117269757 creator A5012791965 @default.
- W2117269757 creator A5018821173 @default.
- W2117269757 creator A5026497865 @default.
- W2117269757 creator A5026517573 @default.
- W2117269757 creator A5032868995 @default.
- W2117269757 creator A5049447022 @default.
- W2117269757 creator A5084874214 @default.
- W2117269757 creator A5088575976 @default.
- W2117269757 creator A5090325884 @default.
- W2117269757 creator A5091097806 @default.
- W2117269757 date "2015-06-23" @default.
- W2117269757 modified "2023-10-05" @default.
- W2117269757 title "Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone" @default.
- W2117269757 cites W1641731911 @default.
- W2117269757 cites W1755902553 @default.
- W2117269757 cites W1832262637 @default.
- W2117269757 cites W1901618512 @default.
- W2117269757 cites W1964648997 @default.
- W2117269757 cites W1966475130 @default.
- W2117269757 cites W1969435130 @default.
- W2117269757 cites W1974326245 @default.
- W2117269757 cites W1978343405 @default.
- W2117269757 cites W1990183706 @default.
- W2117269757 cites W2001674723 @default.
- W2117269757 cites W2003216601 @default.
- W2117269757 cites W2008202147 @default.
- W2117269757 cites W2010296954 @default.
- W2117269757 cites W2018524570 @default.
- W2117269757 cites W2025339136 @default.
- W2117269757 cites W2026049773 @default.
- W2117269757 cites W2027733905 @default.
- W2117269757 cites W2030446659 @default.
- W2117269757 cites W2042527044 @default.
- W2117269757 cites W2051410189 @default.
- W2117269757 cites W2057864934 @default.
- W2117269757 cites W2075188939 @default.
- W2117269757 cites W2077755793 @default.
- W2117269757 cites W2079611827 @default.
- W2117269757 cites W2084073099 @default.
- W2117269757 cites W2088007882 @default.
- W2117269757 cites W2102586905 @default.
- W2117269757 cites W2104226958 @default.
- W2117269757 cites W2124436876 @default.
- W2117269757 cites W2132433659 @default.
- W2117269757 cites W2141734192 @default.
- W2117269757 cites W2148152915 @default.
- W2117269757 cites W2165472416 @default.
- W2117269757 cites W2165541514 @default.
- W2117269757 cites W4213323281 @default.
- W2117269757 doi "https://doi.org/10.1111/boc.201500032" @default.
- W2117269757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26033110" @default.
- W2117269757 hasPublicationYear "2015" @default.
- W2117269757 type Work @default.
- W2117269757 sameAs 2117269757 @default.
- W2117269757 citedByCount "4" @default.
- W2117269757 countsByYear W21172697572016 @default.
- W2117269757 countsByYear W21172697572019 @default.
- W2117269757 countsByYear W21172697572020 @default.
- W2117269757 crossrefType "journal-article" @default.
- W2117269757 hasAuthorship W2117269757A5009297379 @default.
- W2117269757 hasAuthorship W2117269757A5012791965 @default.
- W2117269757 hasAuthorship W2117269757A5018821173 @default.
- W2117269757 hasAuthorship W2117269757A5026497865 @default.
- W2117269757 hasAuthorship W2117269757A5026517573 @default.
- W2117269757 hasAuthorship W2117269757A5032868995 @default.
- W2117269757 hasAuthorship W2117269757A5049447022 @default.
- W2117269757 hasAuthorship W2117269757A5084874214 @default.
- W2117269757 hasAuthorship W2117269757A5088575976 @default.
- W2117269757 hasAuthorship W2117269757A5090325884 @default.
- W2117269757 hasAuthorship W2117269757A5091097806 @default.
- W2117269757 hasConcept C11960822 @default.
- W2117269757 hasConcept C125705527 @default.
- W2117269757 hasConcept C135903288 @default.
- W2117269757 hasConcept C142669718 @default.
- W2117269757 hasConcept C1491633281 @default.
- W2117269757 hasConcept C151000934 @default.
- W2117269757 hasConcept C195794163 @default.
- W2117269757 hasConcept C199528912 @default.
- W2117269757 hasConcept C2776000893 @default.
- W2117269757 hasConcept C2779530196 @default.
- W2117269757 hasConcept C2993400109 @default.
- W2117269757 hasConcept C55493867 @default.
- W2117269757 hasConcept C86803240 @default.
- W2117269757 hasConcept C90301020 @default.
- W2117269757 hasConcept C95444343 @default.
- W2117269757 hasConceptScore W2117269757C11960822 @default.
- W2117269757 hasConceptScore W2117269757C125705527 @default.
- W2117269757 hasConceptScore W2117269757C135903288 @default.
- W2117269757 hasConceptScore W2117269757C142669718 @default.
- W2117269757 hasConceptScore W2117269757C1491633281 @default.
- W2117269757 hasConceptScore W2117269757C151000934 @default.
- W2117269757 hasConceptScore W2117269757C195794163 @default.
- W2117269757 hasConceptScore W2117269757C199528912 @default.
- W2117269757 hasConceptScore W2117269757C2776000893 @default.
- W2117269757 hasConceptScore W2117269757C2779530196 @default.