FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117277612> ?p ?o ?g. }

• W2117277612 endingPage "1701" @default.
• W2117277612 startingPage "1690" @default.
• W2117277612 abstract "We have previously identified a 115-gene signature that characterises the metastatic potential of human primary colon cancers. The signature included the canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice. Here, we identified three new direct Wnt target genes from the signature, and studied their functions in epithelial-mesenchymal transition (EMT), cell migration and experimental metastasis.We examined experimental liver metastases following injection of selected tumour cells into spleens of NOD/SCID mice. Molecular and cellular techniques were used to identify direct transcription target genes of Wnt/β-catenin signals. Microarray analyses and experiments that interfered with cell migration through inhibitors were performed to characterise downstream signalling systems.Three new genes from the colorectal cancer (CRC) metastasis signature, BOP1, CKS2 and NFIL3, were identified as direct transcription targets of β-catenin/TCF4. Overexpression and knocking down of these genes in CRC cells promoted and inhibited, respectively, experimental metastasis in mice, EMT and cell motility in culture. Cell migration was repressed by interfering with distinct signalling systems through inhibitors of PI3K, JNK, p38 mitogen-activated protein kinase and/or mTOR. Gene expression profiling identified a series of migration-promoting genes, which were induced by BOP1, CKS2 and NFIL3, and could be repressed by inhibitors that are specific to these pathways.We identified new direct Wnt/β-catenin target genes, BOP1, CKS2 and NFIL3, which induced EMT, cell migration and experimental metastasis of CRC cells. These genes crosstalk with different downstream signalling systems, and activate migration-promoting genes. These pathways and downstream genes may serve as therapeutic targets in the treatment of CRC metastasis." @default.
• W2117277612 created "2016-06-24" @default.
• W2117277612 creator A5013066671 @default.
• W2117277612 creator A5013313803 @default.
• W2117277612 creator A5015081490 @default.
• W2117277612 creator A5025420008 @default.
• W2117277612 creator A5041372912 @default.
• W2117277612 creator A5054546901 @default.
• W2117277612 creator A5056395986 @default.
• W2117277612 creator A5072925099 @default.
• W2117277612 creator A5082062107 @default.
• W2117277612 creator A5083427695 @default.
• W2117277612 date "2015-07-08" @default.
• W2117277612 modified "2023-10-05" @default.
• W2117277612 title "New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals" @default.
• W2117277612 cites W1963965802 @default.
• W2117277612 cites W1968665517 @default.
• W2117277612 cites W1980525108 @default.
• W2117277612 cites W1996983679 @default.
• W2117277612 cites W2015418522 @default.
• W2117277612 cites W2026260372 @default.
• W2117277612 cites W2029857102 @default.
• W2117277612 cites W2036169332 @default.
• W2117277612 cites W2040196938 @default.
• W2117277612 cites W2041822723 @default.
• W2117277612 cites W2042198997 @default.
• W2117277612 cites W2044823235 @default.
• W2117277612 cites W2053086049 @default.
• W2117277612 cites W2056846905 @default.
• W2117277612 cites W2063391460 @default.
• W2117277612 cites W2067525107 @default.
• W2117277612 cites W2073079990 @default.
• W2117277612 cites W2090636859 @default.
• W2117277612 cites W2090715425 @default.
• W2117277612 cites W2094772268 @default.
• W2117277612 cites W2096033277 @default.
• W2117277612 cites W2097946485 @default.
• W2117277612 cites W2100499830 @default.
• W2117277612 cites W2104546896 @default.
• W2117277612 cites W2109456792 @default.
• W2117277612 cites W2112763851 @default.
• W2117277612 cites W2114014236 @default.
• W2117277612 cites W2115124692 @default.
• W2117277612 cites W2116347075 @default.
• W2117277612 cites W2121288523 @default.
• W2117277612 cites W2128597460 @default.
• W2117277612 cites W2140551998 @default.
• W2117277612 cites W2142890842 @default.
• W2117277612 cites W2149255571 @default.
• W2117277612 cites W2151519283 @default.
• W2117277612 cites W2157537726 @default.
• W2117277612 cites W2163367650 @default.
• W2117277612 cites W2169231894 @default.
• W2117277612 cites W2171857030 @default.
• W2117277612 cites W2262414037 @default.
• W2117277612 doi "https://doi.org/10.1136/gutjnl-2014-307900" @default.
• W2117277612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26156959" @default.
• W2117277612 hasPublicationYear "2015" @default.
• W2117277612 type Work @default.
• W2117277612 sameAs 2117277612 @default.
• W2117277612 citedByCount "135" @default.
• W2117277612 countsByYear W21172776122015 @default.
• W2117277612 countsByYear W21172776122016 @default.
• W2117277612 countsByYear W21172776122017 @default.
• W2117277612 countsByYear W21172776122018 @default.
• W2117277612 countsByYear W21172776122019 @default.
• W2117277612 countsByYear W21172776122020 @default.
• W2117277612 countsByYear W21172776122021 @default.
• W2117277612 countsByYear W21172776122022 @default.
• W2117277612 countsByYear W21172776122023 @default.
• W2117277612 crossrefType "journal-article" @default.
• W2117277612 hasAuthorship W2117277612A5013066671 @default.
• W2117277612 hasAuthorship W2117277612A5013313803 @default.
• W2117277612 hasAuthorship W2117277612A5015081490 @default.
• W2117277612 hasAuthorship W2117277612A5025420008 @default.
• W2117277612 hasAuthorship W2117277612A5041372912 @default.
• W2117277612 hasAuthorship W2117277612A5054546901 @default.
• W2117277612 hasAuthorship W2117277612A5056395986 @default.
• W2117277612 hasAuthorship W2117277612A5072925099 @default.
• W2117277612 hasAuthorship W2117277612A5082062107 @default.
• W2117277612 hasAuthorship W2117277612A5083427695 @default.
• W2117277612 hasConcept C104317684 @default.
• W2117277612 hasConcept C121608353 @default.
• W2117277612 hasConcept C137620995 @default.
• W2117277612 hasConcept C137738243 @default.
• W2117277612 hasConcept C1491633281 @default.
• W2117277612 hasConcept C150194340 @default.
• W2117277612 hasConcept C18431079 @default.
• W2117277612 hasConcept C2779013556 @default.
• W2117277612 hasConcept C502942594 @default.
• W2117277612 hasConcept C54355233 @default.
• W2117277612 hasConcept C62478195 @default.
• W2117277612 hasConcept C86803240 @default.
• W2117277612 hasConcept C95444343 @default.
• W2117277612 hasConceptScore W2117277612C104317684 @default.
• W2117277612 hasConceptScore W2117277612C121608353 @default.
• W2117277612 hasConceptScore W2117277612C137620995 @default.
• W2117277612 hasConceptScore W2117277612C137738243 @default.

• next