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• W2117279368 abstract "Increased passive Na + ,K + fluxes necessitate an efficient activation of the Na + ,K + pump in working muscles to limit the rundown of the Na + ,K + chemical gradients and ensuing loss of excitability. Several studies have demonstrated an increase in Na + ,K + ‐pump rate in working muscles, and in electrically stimulated muscles up to a 22‐fold increase in active Na + ,K + transport has been observed. Excitation‐induced increase in intracellular Na + is believed to be the primary stimulus for Na + ,K + pumping in a contracting muscle. In muscles recovering from electrical stimulation, however, the activity of the pump may stay elevated even after intracellular Na + has been reduced to below the resting level. Moreover, in rat soleus muscles 10‐s stimulation at 60 Hz induced a 5‐fold increase in the activity of the Na + ,K + pump although mean intracellular [Na + ] was unchanged. These findings strongly suggest that a substantial part of the excitation‐induced increase in Na + ,K + ‐pump activity is caused by mechanisms other than increased intracellular [Na + ]. The mechanism behind this activation is not clear, but may involve a change in the affinity of the Na + ,K + pump for intracellular Na + . In addition to intracellular [Na + ], the Na + ,K + pump may be stimulated in contracting muscles by other factors such as catecholamines, calcitonin gene‐related peptide (CGRP), free fatty acids and cytoskeletal links. Together, this activation may form a feed forward mechanism protecting muscles from loss of excitability during periods of contraction by increasing Na + ,K + ‐pump activity prior to erosion of the Na + ,K + chemical gradients. During exercise of high intensity, however, intracellular [Na + ] increases substantially constituting an additional stimulus for the pump." @default.
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• W2117279368 date "1998-02-01" @default.
• W2117279368 modified "2023-10-17" @default.
• W2117279368 title "The regulation of the Na⁺,K⁺pump in contracting skeletal muscle" @default.
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• W2117279368 doi "https://doi.org/10.1046/j.1365-201x.1998.00297.x" @default.
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