Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117296173> ?p ?o ?g. }
- W2117296173 endingPage "885" @default.
- W2117296173 startingPage "874" @default.
- W2117296173 abstract "Polyamines are essential polycations present in all living cells. Polyamine levels are maintained from the diet and de novo synthesis, and their decline with age is associated with various pathologies. Here we show that polyamine levels oscillate in a daily manner. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements. In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Importantly, we found that the decline in polyamine levels with age in mice is associated with a longer circadian period that can be reversed upon polyamine supplementation in the diet. Our findings suggest a crosstalk between circadian clocks and polyamine biosynthesis and open new possibilities for nutritional interventions against the decay in clock's function with age." @default.
- W2117296173 created "2016-06-24" @default.
- W2117296173 creator A5012740914 @default.
- W2117296173 creator A5012811772 @default.
- W2117296173 creator A5026316454 @default.
- W2117296173 creator A5029452672 @default.
- W2117296173 creator A5031711435 @default.
- W2117296173 creator A5039674144 @default.
- W2117296173 creator A5042739421 @default.
- W2117296173 creator A5043619764 @default.
- W2117296173 creator A5044930430 @default.
- W2117296173 creator A5064008475 @default.
- W2117296173 creator A5068483778 @default.
- W2117296173 date "2015-11-01" @default.
- W2117296173 modified "2023-10-14" @default.
- W2117296173 title "Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age" @default.
- W2117296173 cites W1532216753 @default.
- W2117296173 cites W1547594908 @default.
- W2117296173 cites W1973217994 @default.
- W2117296173 cites W1977604796 @default.
- W2117296173 cites W1982172428 @default.
- W2117296173 cites W1987699071 @default.
- W2117296173 cites W1996506131 @default.
- W2117296173 cites W1997426777 @default.
- W2117296173 cites W2004645532 @default.
- W2117296173 cites W2006469044 @default.
- W2117296173 cites W2014313900 @default.
- W2117296173 cites W2016539998 @default.
- W2117296173 cites W2016922540 @default.
- W2117296173 cites W2021229976 @default.
- W2117296173 cites W2025994995 @default.
- W2117296173 cites W2037782139 @default.
- W2117296173 cites W2039466176 @default.
- W2117296173 cites W2040650438 @default.
- W2117296173 cites W2042500733 @default.
- W2117296173 cites W2044458189 @default.
- W2117296173 cites W2053210485 @default.
- W2117296173 cites W2054172123 @default.
- W2117296173 cites W2057040983 @default.
- W2117296173 cites W2058117842 @default.
- W2117296173 cites W2058194275 @default.
- W2117296173 cites W2061015706 @default.
- W2117296173 cites W2073742199 @default.
- W2117296173 cites W2077404705 @default.
- W2117296173 cites W2080019362 @default.
- W2117296173 cites W2084770232 @default.
- W2117296173 cites W2091531174 @default.
- W2117296173 cites W2126110821 @default.
- W2117296173 cites W2126175292 @default.
- W2117296173 cites W2140233939 @default.
- W2117296173 cites W2147621980 @default.
- W2117296173 cites W2148900913 @default.
- W2117296173 cites W2164628441 @default.
- W2117296173 cites W2164824098 @default.
- W2117296173 cites W2167740392 @default.
- W2117296173 cites W2172104926 @default.
- W2117296173 doi "https://doi.org/10.1016/j.cmet.2015.09.011" @default.
- W2117296173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26456331" @default.
- W2117296173 hasPublicationYear "2015" @default.
- W2117296173 type Work @default.
- W2117296173 sameAs 2117296173 @default.
- W2117296173 citedByCount "111" @default.
- W2117296173 countsByYear W21172961732015 @default.
- W2117296173 countsByYear W21172961732016 @default.
- W2117296173 countsByYear W21172961732017 @default.
- W2117296173 countsByYear W21172961732018 @default.
- W2117296173 countsByYear W21172961732019 @default.
- W2117296173 countsByYear W21172961732020 @default.
- W2117296173 countsByYear W21172961732021 @default.
- W2117296173 countsByYear W21172961732022 @default.
- W2117296173 countsByYear W21172961732023 @default.
- W2117296173 crossrefType "journal-article" @default.
- W2117296173 hasAuthorship W2117296173A5012740914 @default.
- W2117296173 hasAuthorship W2117296173A5012811772 @default.
- W2117296173 hasAuthorship W2117296173A5026316454 @default.
- W2117296173 hasAuthorship W2117296173A5029452672 @default.
- W2117296173 hasAuthorship W2117296173A5031711435 @default.
- W2117296173 hasAuthorship W2117296173A5039674144 @default.
- W2117296173 hasAuthorship W2117296173A5042739421 @default.
- W2117296173 hasAuthorship W2117296173A5043619764 @default.
- W2117296173 hasAuthorship W2117296173A5044930430 @default.
- W2117296173 hasAuthorship W2117296173A5064008475 @default.
- W2117296173 hasAuthorship W2117296173A5068483778 @default.
- W2117296173 hasBestOaLocation W21172961731 @default.
- W2117296173 hasConcept C120665830 @default.
- W2117296173 hasConcept C121332964 @default.
- W2117296173 hasConcept C121446783 @default.
- W2117296173 hasConcept C126322002 @default.
- W2117296173 hasConcept C134018914 @default.
- W2117296173 hasConcept C169822122 @default.
- W2117296173 hasConcept C181199279 @default.
- W2117296173 hasConcept C184738001 @default.
- W2117296173 hasConcept C24890656 @default.
- W2117296173 hasConcept C2776109719 @default.
- W2117296173 hasConcept C2777497464 @default.
- W2117296173 hasConcept C2779064383 @default.
- W2117296173 hasConcept C2780115381 @default.
- W2117296173 hasConcept C2781291010 @default.