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- W2117315463 abstract "A series of new poly[N-(2-hydroxypropyl)methacrylamide]-based amphiphilic copolymers were synthesized through a radical copolymerization of a monomeric/hydrophobic fluorophore possessing aggregation-induced emission (AIE) properties with N-(2-hydroxypropyl)methacrylamide. Photophysical properties were investigated using UV–Vis absorbance and fluorescence spectrophotometry. Influences of the polymer structures with different molar ratios of the AIE fluorophores on their photophysical properties were studied. Results show that the AIE fluorophores aggregate in the cores of the micelles formed from the amphiphilic random copolymers and polymers with more hydrophobic AIE fluorophores facilitate stronger aggregations of the AIE segments to obtain higher quantum efficiencies. The polymers reported herein have good water solubility, enabling the application of hydrophobic AIE materials in biological conditions. The polymers were endocytosed by two experimental cell lines, human brain glioblastoma U87MG cells and human esophagus premalignant CP-A, with a distribution into the cytoplasm. The polymers are noncytotoxic to the two cell lines at a polymer concentration of 1 mg/mL. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012" @default.
- W2117315463 created "2016-06-24" @default.
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- W2117315463 date "2011-11-28" @default.
- W2117315463 modified "2023-10-16" @default.
- W2117315463 title "A series of poly[N-(2-hydroxypropyl)methacrylamide] copolymers with anthracene-derived fluorophores showing aggregation-induced emission properties for bioimaging" @default.
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- W2117315463 doi "https://doi.org/10.1002/pola.25841" @default.
- W2117315463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266372" @default.
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