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- W2117316674 endingPage "5812" @default.
- W2117316674 startingPage "5801" @default.
- W2117316674 abstract "ABSTRACT High-risk human papillomaviruses (HPVs) are associated with carcinomas of the cervix and other genital tumors. The HPV oncoprotein E6 is essential for oncogenic transformation. We identify here hADA3, human homologue of the yeast transcriptional coactivator yADA3, as a novel E6-interacting protein and a target of E6-induced degradation. hADA3 binds selectively to the high-risk HPV E6 proteins and only to immortalization-competent E6 mutants. hADA3 functions as a coactivator for p53-mediated transactivation by stabilizing p53 protein. Notably, three immortalizing E6 mutants that do not induce direct p53 degradation but do interact with hADA3 induced the abrogation of p53-mediated transactivation and G 1 cell cycle arrest after DNA damage, comparable to wild-type E6. These findings reveal a novel strategy of HPV E6-induced loss of p53 function that is independent of direct p53 degradation. Given the likely role of the evolutionarily conserved hADA3 in multiple coactivator complexes, inactivation of its function may allow E6 to perturb numerous cellular pathways during HPV oncogenesis." @default.
- W2117316674 created "2016-06-24" @default.
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- W2117316674 date "2002-08-15" @default.
- W2117316674 modified "2023-10-16" @default.
- W2117316674 title "Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3" @default.
- W2117316674 cites W140061535 @default.
- W2117316674 cites W1675635349 @default.
- W2117316674 cites W1763110138 @default.
- W2117316674 cites W1763859619 @default.
- W2117316674 cites W1767781328 @default.
- W2117316674 cites W1831319429 @default.
- W2117316674 cites W1860866234 @default.
- W2117316674 cites W190015672 @default.
- W2117316674 cites W1967960141 @default.
- W2117316674 cites W1968285394 @default.
- W2117316674 cites W1971660947 @default.
- W2117316674 cites W1971870945 @default.
- W2117316674 cites W1975232450 @default.
- W2117316674 cites W1976206018 @default.
- W2117316674 cites W1977041491 @default.
- W2117316674 cites W1977052152 @default.
- W2117316674 cites W1978775178 @default.
- W2117316674 cites W1978943108 @default.
- W2117316674 cites W1979392487 @default.
- W2117316674 cites W1986169988 @default.
- W2117316674 cites W1990030653 @default.
- W2117316674 cites W1991263063 @default.
- W2117316674 cites W1991494214 @default.
- W2117316674 cites W1995523055 @default.
- W2117316674 cites W1995856480 @default.
- W2117316674 cites W1997388033 @default.
- W2117316674 cites W1999691484 @default.
- W2117316674 cites W2002705413 @default.
- W2117316674 cites W2013890168 @default.
- W2117316674 cites W2020954198 @default.
- W2117316674 cites W2021693846 @default.
- W2117316674 cites W2027881996 @default.
- W2117316674 cites W2029735450 @default.
- W2117316674 cites W2033909834 @default.
- W2117316674 cites W2034496567 @default.
- W2117316674 cites W2038500217 @default.
- W2117316674 cites W2039382131 @default.
- W2117316674 cites W2049986428 @default.
- W2117316674 cites W2051992774 @default.
- W2117316674 cites W2053956596 @default.
- W2117316674 cites W2056497285 @default.
- W2117316674 cites W2059696301 @default.
- W2117316674 cites W2060786724 @default.
- W2117316674 cites W2062809474 @default.
- W2117316674 cites W2063877452 @default.
- W2117316674 cites W2085195718 @default.
- W2117316674 cites W2095217266 @default.
- W2117316674 cites W2095669369 @default.
- W2117316674 cites W2096501714 @default.
- W2117316674 cites W2097921658 @default.
- W2117316674 cites W2100331209 @default.
- W2117316674 cites W2106526289 @default.
- W2117316674 cites W2108720228 @default.
- W2117316674 cites W2112534911 @default.
- W2117316674 cites W2121046447 @default.
- W2117316674 cites W2125748368 @default.
- W2117316674 cites W2132087311 @default.
- W2117316674 cites W2132440338 @default.
- W2117316674 cites W2134484018 @default.
- W2117316674 cites W2136877893 @default.
- W2117316674 cites W2138027990 @default.
- W2117316674 cites W2139573924 @default.
- W2117316674 cites W2140014254 @default.
- W2117316674 cites W2143019738 @default.
- W2117316674 cites W2143103843 @default.
- W2117316674 cites W2146697637 @default.
- W2117316674 cites W2148208243 @default.
- W2117316674 cites W2151085515 @default.
- W2117316674 cites W2152159644 @default.
- W2117316674 cites W2158755626 @default.
- W2117316674 cites W2166091854 @default.
- W2117316674 cites W2166997624 @default.
- W2117316674 cites W2175247758 @default.
- W2117316674 cites W2212206565 @default.
- W2117316674 cites W22520275 @default.
- W2117316674 cites W2334464812 @default.
- W2117316674 cites W4250214354 @default.
- W2117316674 doi "https://doi.org/10.1128/mcb.22.16.5801-5812.2002" @default.
- W2117316674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133989" @default.
- W2117316674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12138191" @default.
- W2117316674 hasPublicationYear "2002" @default.