FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117324114> ?p ?o ?g. }

• W2117324114 endingPage "33" @default.
• W2117324114 startingPage "26" @default.
• W2117324114 abstract "Tumor cells, just as other living cells, possess the potential for proliferation, differentiation, cell cycle arrest, and apoptosis. There is a specific metabolic phenotype associated with each of these conditions, characterized by the production of both energy and special substrates necessary for the cells to function in that particular state. Unlike that of normal living cells, the metabolic phenotype of tumor cells supports the proliferative state.To present the metabolic hypothesis that (1) cell transformation and tumor growth are associated with the activation of metabolic enzymes that increase glucose carbon utilization for nucleic acid synthesis, while enzymes of the lipid and amino acid synthesis pathways are activated in tumor growth inhibition, and (2) phosphorylation and allosteric and transcriptional regulation of intermediary metabolic enzymes and their substrate availability together mediate and sustain cell transformation from one condition to another.Evidence is presented that demonstrates opposite changes in metabolic phenotypes induced by TGF-beta, a cell-transforming agent, and tumor growth-inhibiting phytochemicals such as genistein and Avemar, or novel synthetic anti-leukemic drugs such as STI571 (Gleevec). Intermediary metabolic enzymes that mediate the growth signaling pathways and promote malignant cell transformation may serve as high-efficacy nongenetic novel targets for cancer therapies." @default.
• W2117324114 created "2016-06-24" @default.
• W2117324114 creator A5008524910 @default.
• W2117324114 creator A5085396858 @default.
• W2117324114 creator A5085975995 @default.
• W2117324114 date "2002-01-01" @default.
• W2117324114 modified "2023-10-02" @default.
• W2117324114 title "A Metabolic Hypothesis of Cell Growth and Death in Pancreatic Cancer" @default.
• W2117324114 cites W1521598031 @default.
• W2117324114 cites W1530867102 @default.
• W2117324114 cites W1602530349 @default.
• W2117324114 cites W1946359192 @default.
• W2117324114 cites W1976632546 @default.
• W2117324114 cites W1977366525 @default.
• W2117324114 cites W1986640302 @default.
• W2117324114 cites W1995360262 @default.
• W2117324114 cites W1997703676 @default.
• W2117324114 cites W2000428596 @default.
• W2117324114 cites W2006294797 @default.
• W2117324114 cites W2008769187 @default.
• W2117324114 cites W2025311904 @default.
• W2117324114 cites W2045053669 @default.
• W2117324114 cites W2053830735 @default.
• W2117324114 cites W2061146912 @default.
• W2117324114 cites W2063229165 @default.
• W2117324114 cites W2072451938 @default.
• W2117324114 cites W2075431945 @default.
• W2117324114 cites W2079854321 @default.
• W2117324114 cites W2081003973 @default.
• W2117324114 cites W2085665305 @default.
• W2117324114 cites W2102955022 @default.
• W2117324114 cites W2104356108 @default.
• W2117324114 cites W2112371447 @default.
• W2117324114 cites W2128235721 @default.
• W2117324114 cites W2130941632 @default.
• W2117324114 cites W2156979413 @default.
• W2117324114 cites W2169921289 @default.
• W2117324114 cites W2180159320 @default.
• W2117324114 cites W2182596905 @default.
• W2117324114 cites W2321492184 @default.
• W2117324114 doi "https://doi.org/10.1097/00006676-200201000-00004" @default.
• W2117324114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11741179" @default.
• W2117324114 hasPublicationYear "2002" @default.
• W2117324114 type Work @default.
• W2117324114 sameAs 2117324114 @default.
• W2117324114 citedByCount "46" @default.
• W2117324114 countsByYear W21173241142012 @default.
• W2117324114 countsByYear W21173241142013 @default.
• W2117324114 countsByYear W21173241142014 @default.
• W2117324114 countsByYear W21173241142016 @default.
• W2117324114 countsByYear W21173241142018 @default.
• W2117324114 countsByYear W21173241142019 @default.
• W2117324114 countsByYear W21173241142020 @default.
• W2117324114 countsByYear W21173241142021 @default.
• W2117324114 countsByYear W21173241142023 @default.
• W2117324114 crossrefType "journal-article" @default.
• W2117324114 hasAuthorship W2117324114A5008524910 @default.
• W2117324114 hasAuthorship W2117324114A5085396858 @default.
• W2117324114 hasAuthorship W2117324114A5085975995 @default.
• W2117324114 hasConcept C121608353 @default.
• W2117324114 hasConcept C1491633281 @default.
• W2117324114 hasConcept C181199279 @default.
• W2117324114 hasConcept C192989942 @default.
• W2117324114 hasConcept C29537977 @default.
• W2117324114 hasConcept C31033888 @default.
• W2117324114 hasConcept C502942594 @default.
• W2117324114 hasConcept C54355233 @default.
• W2117324114 hasConcept C55493867 @default.
• W2117324114 hasConcept C62112901 @default.
• W2117324114 hasConcept C62478195 @default.
• W2117324114 hasConcept C86803240 @default.
• W2117324114 hasConcept C95444343 @default.
• W2117324114 hasConcept C96232424 @default.
• W2117324114 hasConceptScore W2117324114C121608353 @default.
• W2117324114 hasConceptScore W2117324114C1491633281 @default.
• W2117324114 hasConceptScore W2117324114C181199279 @default.
• W2117324114 hasConceptScore W2117324114C192989942 @default.
• W2117324114 hasConceptScore W2117324114C29537977 @default.
• W2117324114 hasConceptScore W2117324114C31033888 @default.
• W2117324114 hasConceptScore W2117324114C502942594 @default.
• W2117324114 hasConceptScore W2117324114C54355233 @default.
• W2117324114 hasConceptScore W2117324114C55493867 @default.
• W2117324114 hasConceptScore W2117324114C62112901 @default.
• W2117324114 hasConceptScore W2117324114C62478195 @default.
• W2117324114 hasConceptScore W2117324114C86803240 @default.
• W2117324114 hasConceptScore W2117324114C95444343 @default.
• W2117324114 hasConceptScore W2117324114C96232424 @default.
• W2117324114 hasIssue "1" @default.
• W2117324114 hasLocation W21173241141 @default.
• W2117324114 hasLocation W21173241142 @default.
• W2117324114 hasOpenAccess W2117324114 @default.
• W2117324114 hasPrimaryLocation W21173241141 @default.
• W2117324114 hasRelatedWork W2083693850 @default.
• W2117324114 hasRelatedWork W2351474733 @default.
• W2117324114 hasRelatedWork W2361888356 @default.
• W2117324114 hasRelatedWork W2374592133 @default.
• W2117324114 hasRelatedWork W2386515470 @default.
• W2117324114 hasRelatedWork W2532041 @default.

• next